Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

Mycobacterial diseases in pediatric hematopoietic SCT recipients

Bone Marrow Transplantation volume 46, pages 766–768 (2011)Cite this article

Subjects

The incidence of mycobacterial disease (MBD), including that due to Mycobacterium tuberculosis (MT) and non-tuberculous mycobacteria (NTM), was considered in the past to be a rare complication among SCT recipients.1 However, in recent years, there has been an increasing number of reports of MBD in this population.2 The increase has been attributed to a number of factors, such as the availability of new molecular biology methods to recover and identify mycobacteria, the increasing use of T-cell depletion techniques that may impair host defense recovery and the increasing number of SCT in countries in which the prevalence of tuberculosis is high.3

Spain is a country with a high incidence of tuberculosis, which was estimated in 2003 as 28 cases per 105 inhabitants per year,4 and NTM diseases have increased significantly in the last two decades.5 De la Camara et al.6 published in 2000 the results of a Spanish survey of tuberculosis after SCT in adult patients. They reported an incidence of 20 confirmed cases (eight autologous and twelve allogeneic transplants) among 8013 patients (0.249%), with a high mortality rate (55%). GVHD, corticosteroid treatment and TBI appeared to be associated with tuberculosis in allogeneic recipients.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Navari R, Sullivan K, Springmeyer S, Siegel MS, Meyers JD, Buckner CD et al. Mycobacterial infections in marrow transplant recipients. Transplantation 1983; 36: 509–513.

    Article  CAS  Google Scholar 

  2. Hughes WT . Mycobacterial infections in bone marrow transplant recipients. Biol Blood Marrow Transplant 2000; 6: 359–360.

    Article  CAS  Google Scholar 

  3. Cordonnier C, Martino R, Trabasso P, Held TK, Akan H, Ward MS et al. Mycobacterial infection: a difficult and late diagnosis in stem cell transplant recipients. Clin Infect Dis 2004; 38: 1229–1236.

    Article  CAS  Google Scholar 

  4. WHO. Global tuberculosis control-surveillance planning, financing. WHO Report 2005. http://www.who.int./tb/publications/global_report/2005/en/.

  5. Altet N . Non-tuberculous mycobacteria: an emerging disease? An Pediatr (Barc) 2009; 71: 185–188.

    Article  Google Scholar 

  6. De la Camara P, Martino R, Granados E, Rodriguez-Salvanes FJ, Rovira M, Cabrera R et al. Tuberculosis after hematopoietic stem cell transplantation: incidence, clinical characteristics and outcome. Bone Marrow Transplant 2000; 26: 291–298.

    Article  CAS  Google Scholar 

  7. Weinstock DM, Feinsten MB, Sepkowitz KA, Jakubowsky A . High rates of infection and colonization by nontuberculous mycobacteria after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2003; 31: 1015–1021.

    Article  CAS  Google Scholar 

  8. Akan A, Arslan O, Akan OA . Tuberculosis in stem cell transplant patients. J Hosp Infect 2006; 62: 421–426.

    Article  CAS  Google Scholar 

  9. Gaviria JM, Garcia PJ, Garrido SM, Corey L, Boeckh M . Nontuberculous mycobacterial infections in hematopoietic stem cell transplant recipients: characteristics of respiratory and catheter-related infections. Biol Blood Marrow Transplant 2000; 6: 361–369.

    Article  CAS  Google Scholar 

  10. Unal FV, Yen C, Saiman L, George D, Della-Latta P, van de Ven C et al. A low incidence of nontuberculous mycobacterial infections in pediatric hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2006; 12: 1188–1197.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Hospital Ramon y Cajal, Madrid, Spain

    A Muñoz & M S Maldonado

  2. Hospital Ni,

    M Gonzalez-Vicent

  3. ñ,

    M Gonzalez-Vicent

  4. o Jesus, Madrid, Spain

    M Gonzalez-Vicent

  5. Department of Pediatrics, Hospital Sant Pau, Barcelona, Spain

    I Badell

  6. Hospital Valle de Hebron, Barcelona, Spain

    C Diaz de Heredia

  7. Hospital la Paz, Madrid, Spain

    A Martinez

Authors
  1. A Muñoz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Gonzalez-Vicent
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I Badell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C Diaz de Heredia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M S Maldonado
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Muñoz.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muñoz, A., Gonzalez-Vicent, M., Badell, I. et al. Mycobacterial diseases in pediatric hematopoietic SCT recipients. Bone Marrow Transplant 46, 766–768 (2011). https://doi.org/10.1038/bmt.2010.183

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/bmt.2010.183

This article is cited by

Search

Advanced search

Quick links