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The Mexican Way: a feasible approach to avoid DMSO toxicity

Bone Marrow Transplantation volume 46, pages 469–471 (2011)Cite this article

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We read with great interest the paper of López-Otero et al.,1 in which they describe a feasible approach of using high-dose chemotherapy and autologous transplantation in patients with multiple myeloma without cryopreservation of the PBSCs. In their study, they used a G-CSF-based steady-state mobilization strategy immediately followed by a single dose of high-dose melphalan (200 mg/m2, day −1) and transplantation of the fridge-stored (+4 °C) autologous, unmanipulated PBSCs on day 0. Using this regimen they observed response and survival rates comparable to those achieved by a classical transplantation strategy using cryopreserved autografts, which has also been previously demonstrated by Carey et al. and several other groups.2, 3

The major aim of this study, as already demonstrated in their previous studies, was reduction of costs by sparing the stem cell cryopreservation procedure. Thereby, their method was affordable and permitted access to high-dose therapy for individuals living in countries with limited access to medical high-tech facilities, such as Mexico.4, 5, 6

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References

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Authors and Affiliations

  1. Department for Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany

    T Schroeder, R Fenk, C Saure, A Czibere, I Bruns, F Zohren, R Haas & G Kobbe

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  1. T Schroeder
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  2. R Fenk
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  3. C Saure
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  8. G Kobbe
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Correspondence to T Schroeder.

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Schroeder, T., Fenk, R., Saure, C. et al. The Mexican Way: a feasible approach to avoid DMSO toxicity. Bone Marrow Transplant 46, 469–471 (2011). https://doi.org/10.1038/bmt.2010.140

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