A molecular cascade involving the transcription factor SIX6 and its target gene p16INK4a causes the death of neurons that link the eye to the brain. This discovery deepens our understanding of a common form of blindness, glaucoma.
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A microscale optical implant for continuous in vivo monitoring of intraocular pressure
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Dhande, O. S. & Huberman, A. D. Curr. Opin. Neurobiol. 24, 133–142 (2014).
Kwon, Y. H., Fingert, J. H., Kuehn, M. H. & Alward, W. L. M. N. Engl. J. Med. 360, 1113–1124 (2009).
Weinreb, R. N., Aung, T. & Medeiros, F. A. J. Am. Med. Assoc. 311, 1901–1911 (2014).
Skowronska-Krawczyk, D. et al. Mol. Cell 59, 931–940 (2015).
Jain, S. & Aref, A. A. J. Ophthalmic Vis. Res. 10, 178–183 (2015).
Tielsch, J. M. et al. J. Am. Med. Assoc. 266, 369–374 (1991).
Anderson, A. M., Weasner, B. M., Weasner, B. P. & Kumar, J. P. Development 139, 991–1000 (2012).
Della Santina, L., Inman, D. M., Lupien, C. B., Horner, P. J. & Wong, R. O. J. Neurosci. 33, 17444–17457 (2013).
El-Danaf, R. N. & Huberman, A. D. J. Neurosci. 35, 2329–2343 (2015).
Ward, N. J., Ho, K. W., Lambert, W. S., Weitlauf, C. & Calkins, D. J. J. Neurosci. 34, 3161–3170 (2014).
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Huberman, A., El-Danaf, R. Assassins of eyesight. Nature 527, 456–457 (2015). https://doi.org/10.1038/527456a
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DOI: https://doi.org/10.1038/527456a
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A microscale optical implant for continuous in vivo monitoring of intraocular pressure
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