Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430
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Ohlsson, R. The coherent Mediator. Nature 467, 406–407 (2010). https://doi.org/10.1038/467406a
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DOI: https://doi.org/10.1038/467406a