Abstract
A review of the literature reveals that there is little conclusive evidence that DNA of homologous human chromosomes replicates synchronously. This means that final identification of morphologically similar chromosome pairs by autoradiography as well as the association of particular chromosomes with specific human disease syndromes, genetic loci or abnormal genetic interchanges are still only tentative.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Taylor, J. H., Woods, P. S., and Hughes, W. L., Proc. US Nat. Acad. Sci., 43, 122 (1957).
Harris, H., Watkins, J. F., Ford, C. E., and Schoefl, G. I., J. Cell. Sci., 1, 1 (1966).
Rosenbloom, F. M., Kelley, W. N., Henderson, J. F., and Seegmiller, J. E., Lancet, ii, 305 (1967).
Migeon, B. R., Der Kaloustian, V. M., Nyhan, W. L., Young, W. J., and Childs, B., Science, 160, 425 (1968).
German, J. F., Trans. NY Acad. Sci., 24, 394 (1962).
Moorhead, P. S., and Defendi, V., J. Cell Biol., 16, 202 (1963).
Schmid, W., Cytogenetics, 2, 175 (1963).
Miller, O. J., Breg, W. R., Warburton, D., Miller, D. A., Firschein, I. L., and Hirschhorn, K., Cytogenetics, 5, 137 (1966).
Warburton, D., Miller, D. A., Miller, O. J., Breg, W. R., De Capoa, A., and Shaw, M. W., Amer. J. Human Genet., 19, 399 (1967).
Giannelli, F., Nature, 208, 669 (1965).
Yunis, J. J., Hook, E. B., and Mayer, M., Lancet, ii, 935 (1964).
Yunis, J. J., Hook, E. B., and Mayer, M., Amer. J. Human Genet., 17, 191 (1965).
Mickkelsen, M., Ann. Human Genet., 30, 325 (1967).
Hecht, F., Case, M. P., Lovrein, E. W., Higgins, J. V., Thuline, H. C., and Melnyk, J., Science, 161, 371 (1968).
Bloom, G. E., and Gerald, P. S., Meeting Amer. Soc. Human Genet., Toronto (Abstract) (1967).
Bloom, G. E., and Gerald, P. S., Amer. J. Hum. Genet., 20, 499 (1968).
Bloom, G. E., Gerald, P. S., and Reisman, L. E., Science, 156, 1746 (1967).
Bloom, G. E., Gerald, P. S., and Diamond, L. K., Soc. Pediat. Res., Thirty-sixth Ann. Meeting (Abstract) (1966).
German, J. L., in Cytogenetics of Cells in Culture (edit. by Harris, R. J. C.), 191 (Academic Press, New York, 1964).
Hsu, T. C., Schmid, W., and Stubblefield, E., in Role of Chromosomes in Development (edit. by Locke, M.), 83 (Academic Press, New York, 1964).
Hsu, T. C., J. Cell Biol., 23, 53 (1964).
Gey, W., Humangenetik, 2, 246 (1966).
Kikuchi, Y., and Sandberg, A. A., J. Nat. Cancer Inst., 32, 1109 (1964).
Sandberg, A. A., Takagi, N., Schmidt, M. L., and Bross, I. D., Cytogenetics, 7, 298 (1968).
Gilbert, C. W., Lajtha, L. G., Muldal, S., and Ockey, C. H., Nature, 209, 537 (1966).
Giannelli, F., and Howlett, R. M., Cytogenetics, 5, 186 (1966).
Bias, W. B., and Migeon, B. R., Amer. J. Human Genet., 19, 393 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STEELE, M. Autoradiography may be Unreliable for Identifying Human Chromosomes. Nature 221, 1114–1116 (1969). https://doi.org/10.1038/2211114a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2211114a0
This article is cited by
-
Cytogenetic studies of chromosome replication in Zea mays L.: Regulation of homologue synchrony
Chromosoma (1974)
-
Chromosomes and DNA-replication of rat kangaroo cells (PtK2)
Chromosoma (1972)
-
Progressive Neuromuscular and Skeletal Disorders in a Male with an Acrocentric Supernumerary Chromosome
Nature (1970)
-
Human chromosomology: Random association of acrocentrics
Genetica (1970)
-
Pattern analysis of long arm grain count as a criterion of homology in eight cases of Bp-
Human Genetics (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
