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Determination of Nicotine and its Metabolite, Cotinine, in Urine by Gas Chromatography

Abstract

A VARIETY of methods have been described for the identification and determination of nicotine in biological fluids1–4; however, they lack sensitivity, specificity and are tedious for routine analysis.

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References

  1. Jakzkewitz, H., Hoppe-Seyler's Z. Physiol. Chem., 292, 94 (1953).

    Article  Google Scholar 

  2. Fabre, R., et al., Ann. Pharm. Franc., 10, 579 (1952).

    CAS  PubMed  Google Scholar 

  3. Desoille, H., et al., Arch. Mal. Prof., 24, 422 (1963).

    CAS  PubMed  Google Scholar 

  4. Ganz, A., and Kelsey, F. E., Fed. Proc., 9, 274 (1950).

    Google Scholar 

  5. Quin, L. D., and Pappas, N. A., Agric. Food Chem., 10, 79 (1962).

    Article  CAS  Google Scholar 

  6. Goldbaum, L. R., and Domanski, J. J., Prog. in Chem. Toxicol., 2, 221 (Academic Press Inc., New York, 1965).

    Google Scholar 

  7. Beckett, A. H., Rowland, M., and Triggs, E. J., Nature, 207, 200 (1965).

    Article  ADS  CAS  Google Scholar 

  8. McNiven, N. L., et al., Nature, 208, 788 (1965).

    Article  ADS  CAS  Google Scholar 

  9. Haag, H. B., and Larson, P. S., J. Pharm. Exp. Therap., 76, 235 (1942).

    CAS  Google Scholar 

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BECKETT, A., TRIGGS, E. Determination of Nicotine and its Metabolite, Cotinine, in Urine by Gas Chromatography. Nature 211, 1415–1417 (1966). https://doi.org/10.1038/2111415a0

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