Featured
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News |
Stem-cell line given the nod
NIH moves to approve cells in limbo after rule change.
- Brendan Borrell
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Letter |
DNMT1 maintains progenitor function in self-renewing somatic tissue
Progenitor cells sustain the capacity of self-renewing tissues for proliferation while suppressing cell cycle exit and terminal differentiation. DNA methylation is one potential epigenetic mechanism for the cellular memory needed to preserve the somatic progenitor state through cell divisions. The DNA methyltransferase 1 and other regulators of DNA methylation are now shown to be essential for epidermal progenitor cell function.
- George L. Sen
- , Jason A. Reuter
- & Paul A. Khavari
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Letter |
KAP1 controls endogenous retroviruses in embryonic stem cells
Much of the mammalian genome is derived from retroelements, a significant proportion of which are endogenous retroviruses (ERVs). ERVs are transcriptionally silenced during early embryogenesis by histone and DNA methylation, but the initiators of this process are largely unknown. Here, deletion of KAP1 is shown to lead to a marked upregulation of a range of ERVs in mouse embryonic stem cells and in early embryos.
- Helen M. Rowe
- , Johan Jakobsson
- & Didier Trono
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Letter |
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Polycomb proteins have a key role in regulating the expression of genes essential for development, differentiation and maintenance of cell fates. Here, Polycomb repressive complex 2 (PRC2) is shown to form a complex with JARID2, a Jumonji domain protein. JARID2 is required for the binding of Polycomb proteins to target genes in embryonic stem cells as well as for the proper differentiation of ES cells.
- Diego Pasini
- , Paul A. C. Cloos
- & Kristian Helin
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Article |
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
The differentiation of an embryonic stem cell (ESC) requires both suppression of the self-renewal process and activation of the specific differentiation pathway. The let-7 family of microRNAs (miRNAs) are now shown to suppress the self-renewal program in cells that are normally unable to silence this program, whereas introduction of ESC cell cycle regulating miRNAs blocks the action of let-7. Thus, the interplay between these two groups of miRNAs dictates cell fate.
- Collin Melton
- , Robert L. Judson
- & Robert Blelloch
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