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| Open AccessSignalling by senescent melanocytes hyperactivates hair growth
Senescent melanocytes of skin nevi drive hyperactivation of hair growth through the signalling factor SPP1.
- Xiaojie Wang
- , Raul Ramos
- & Maksim V. Plikus
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Article |
A phosphate-sensing organelle regulates phosphate and tissue homeostasis
PXo bodies, non-canonical multilamellar organelles, serve as a reservoir for intracellular inorganic phosphate and are a critical regulator of both cytosolic phosphate levels and tissue homeostasis.
- Chiwei Xu
- , Jun Xu
- & Norbert Perrimon
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Article |
Retrograde movements determine effective stem cell numbers in the intestine
Small intestinal crypts contain twice as many effective stem cells as large intestinal crypts, and this difference is determined by the degree of Wnt-driven retrograde cell movement—which is largely absent in the large intestine—counteracting conveyor-belt-like upward movement.
- Maria Azkanaz
- , Bernat Corominas-Murtra
- & Jacco van Rheenen
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Article |
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche
Computational modelling and mouse genetics approaches show that multipotent progenitor cells that have the potential to populate the hepato-pancreato-biliary lineage tree persist in the pancreato-biliary organ rudiment.
- David Willnow
- , Uwe Benary
- & Francesca M. Spagnoli
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Article |
Tracing oncogene-driven remodelling of the intestinal stem cell niche
By inducing changes in surrounding tissue, mutant intestinal stem cells create an unfavourable niche environment that gives them a competitive advantage over non-mutant neighbours.
- Min Kyu Yum
- , Seungmin Han
- & Benjamin D. Simons
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Article |
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Stress inhibits hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.
- Sekyu Choi
- , Bing Zhang
- & Ya-Chieh Hsu
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Article |
MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche
A subset of intestinal stromal cells that is regulated by the kinase MAP3K2 protects intestinal stem cells against injury by producing the WNT agonist R-spondin 1.
- Ningbo Wu
- , Hongxiang Sun
- & Bing Su
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Article |
In situ mapping identifies distinct vascular niches for myelopoiesis
A combination of fluorescent antibodies is used to build visual maps of all myeloid cells in the bone marrow, providing new insight into how the bone marrow microenvironment regulates cell-fate decisions.
- Jizhou Zhang
- , Qingqing Wu
- & Daniel Lucas
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Article |
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
Single-cell RNA-sequencing analysis of intestinal mesenchyme identified a population of fibroblasts that produce prostaglandin E2, which, when disrupted, prevented initiation of intestinal tumours.
- Manolis Roulis
- , Aimilios Kaklamanos
- & Richard A. Flavell
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Letter |
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Ageing-associated decline in intestinal stem cell function is mediated by increased Notum, a protein inhibitor of stemness-maintaining Wnt signalling, which is secreted by Paneth cells.
- Nalle Pentinmikko
- , Sharif Iqbal
- & Pekka Katajisto
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Letter |
An apical hypoxic niche sets the pace of shoot meristem activity
Hypoxia in the shoot meristem of Arabidopsis links the regulation of metabolic activity to development by inhibiting proteolysis of a substrate of the N-degron pathway, which controls class-III homeodomain-leucine zipper transcription factors.
- Daan A. Weits
- , Alicja B. Kunkowska
- & Francesco Licausi
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Letter |
VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche
In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.
- Dantong Li
- , Wenzhi Xue
- & Weijun Pan
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Letter |
Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.
- Friedrich G. Kapp
- , Julie R. Perlin
- & Leonard I. Zon
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Letter |
GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
GLI1-positive cells in the colon secrete Wnt ligands and thereby support homeostasis of intestinal stem cells.
- Bahar Degirmenci
- , Tomas Valenta
- & Konrad Basler
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Letter |
Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.
- Michal Shoshkes-Carmel
- , Yue J. Wang
- & Klaus H. Kaestner
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Letter |
Blastocyst-like structures generated solely from stem cells
Trophoblast and embryonic stem cells interact in vitro to form structures that resemble early blastocysts, and the embryo provides signals that drive early trophectoderm development and implantation.
- Nicolas C. Rivron
- , Javier Frias-Aldeguer
- & Niels Geijsen
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Letter |
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
An evolutionarily conserved alveolar epithelial progenitor lineage that derives from alveolar type 2 cells is responsive to Wnt signalling and acts as a major facultative progenitor in regenerating the distal lung.
- William J. Zacharias
- , David B. Frank
- & Edward E. Morrisey
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Article |
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
During emergency myelopoiesis in mice, clusters of self-renewing granulocyte/macrophage progenitors (GMP) are transiently formed in the bone marrow cavity to produce a burst of myeloid cells; in leukaemia, GMP clusters persist and constantly generate myeloid leukaemia cells.
- Aurélie Hérault
- , Mikhail Binnewies
- & Emmanuelle Passegué
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Letter |
Interplay between metabolic identities in the intestinal crypt supports stem cell function
The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.
- Maria J. Rodríguez-Colman
- , Matthias Schewe
- & Boudewijn M. T. Burgering
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Article |
Distinct bone marrow blood vessels differentially regulate haematopoiesis
Bone marrow endothelial cells have dual roles in the regulation of haematopoietic stem cell maintenance and in the trafficking of blood cells between the bone marrow and the blood circulatory system; this study shows that these different functions are regulated by distinct types of endothelial blood vessels with different permeability properties, affecting the metabolic state of their neighbouring stem cells.
- Tomer Itkin
- , Shiri Gur-Cohen
- & Tsvee Lapidot
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Letter |
Visualization of a short-range Wnt gradient in the intestinal stem-cell niche
Generation of an epitope-tagged, functional Wnt3 knock-in allele, the signal produced by Paneth cells to regulate intestinal stem cells.
- Henner F. Farin
- , Ingrid Jordens
- & Hans Clevers
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Letter |
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche
Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.
- James Y. Chen
- , Masanori Miyanishi
- & Irving L. Weissman
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Article |
A perisinusoidal niche for extramedullary haematopoiesis in the spleen
Haematopoietic stem cells normally reside in a bone marrow niche but they are recruited to the spleen after physiological stresses; here, endothelial cells and stromal cells around sinusoidal blood vessels of the spleen are shown to secrete key niche factors to support this process.
- Christopher N. Inra
- , Bo O. Zhou
- & Sean J. Morrison
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Letter |
Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal
α-catulin is identified as a marker to locate functional haematopoiteic stem cells in deep imaging experiments of bone marrow, showing that α-catulin–GFP+c-kit+ cells commonly reside in perisinusoidal niches throughout the bone marrow.
- Melih Acar
- , Kiranmai S. Kocherlakota
- & Sean J. Morrison
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Article |
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
In the uninjured liver, a population of self-renewing, diploid hepatocytes is identified near the central vein; these cells respond to Wnt signals that are provided by the adjacent central vein endothelial cells, and can give rise to all other hepatocytes to maintain liver homeostasis.
- Bruce Wang
- , Ludan Zhao
- & Roel Nusse
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Letter |
Nanotubes mediate niche–stem-cell signalling in the Drosophila testis
Drosophila male germline stem cells form previously unrecognized structures, microtubule-based nanotubes, which extend into the hub, a major niche component, to mediate the niche–stem-cell signalling.
- Mayu Inaba
- , Michael Buszczak
- & Yukiko M. Yamashita
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Letter |
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.
- Kailin R. Mesa
- , Panteleimon Rompolas
- & Valentina Greco
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Letter |
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.
- Rene C. Adam
- , Hanseul Yang
- & Elaine Fuchs
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Letter |
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.
- Lorena Arranz
- , Abel Sánchez-Aguilera
- & Simón Méndez-Ferrer
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Letter |
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation
Transcription factor Foxc1 is a key regulator of haematopoietic stem/progenitor cell niche formation.
- Yoshiki Omatsu
- , Masanari Seike
- & Takashi Nagasawa
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Article |
Arteriolar niches maintain haematopoietic stem cell quiescence
Immunofluorescence imaging and computational modelling are used to study the spatial distribution of different cell types within the haematopoietic stem cell (HSC) niche; findings show that quiescent HSCs associate specifically with small arterioles that are preferentially found in the endosteal bone marrow and are essential in maintaining this quiescence.
- Yuya Kunisaki
- , Ingmar Bruns
- & Paul S. Frenette
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Article |
Spatial organization within a niche as a determinant of stem-cell fate
By combining lineage tracing with intravital microscopy, the position of a stem cell within its extended mouse hair follicle niche is shown to control its long-term fate and behaviour; laser ablation to remove restricted cell populations shows that bulge stem cells are dispensable for hair regeneration, and non-hair epithelial cells may change their fate to compensate and sustain hair growth.
- Panteleimon Rompolas
- , Kailin R. Mesa
- & Valentina Greco
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Letter |
Differential stem- and progenitor-cell trafficking by prostaglandin E2
Endogenous prostaglandin E2 (PGE2) is a potent regulator of haematopoietic stem cell (HSC) retention in the bone marrow; inhibition of endogenous PGE2 signalling by non-steroidal anti-inflammatory drugs results in enhanced HSC and haematopoietic progenitor cell mobility via E-prostanoid 4 (EP4) receptor antagonism.
- Jonathan Hoggatt
- , Khalid S. Mohammad
- & Louis M. Pelus
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Letter |
Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche
The hilum (a transitional region) of the mouse ovary is identified as a stem cell niche of the ovarian surface epithelium, and its cells are prone to malignant transformation after inactivation of common tumour suppressor genes, suggesting that they may be the origin of ovarian carcinoma.
- Andrea Flesken-Nikitin
- , Chang-Il Hwang
- & Alexander Yu. Nikitin
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Letter |
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
Targeted deletion of the chemokine Cxcl12 in different bone marrow stromal cell populations shows that distinct niches exist in the bone marrow for haematopoietic stem cells and lineage-committed progenitors.
- Adam Greenbaum
- , Yen-Michael S. Hsu
- & Daniel C. Link
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Letter |
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
A study of the physiological sources of the chemokine CXCL12 in mice shows that haematopoietic stem cells occupy a perivascular niche in the bone marrow whereas early lymphoid progenitors occupy a distinct endosteal niche.
- Lei Ding
- & Sean J. Morrison
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Article |
The aged niche disrupts muscle stem cell quiescence
The expression of fibroblast growth factor in aged muscle fibre, the muscle stem cell niche, is shown to cause satellite cells to lose the capacity for self-renewal, and is thus an age-dependent change that directly influences stem cell quiescence and function.
- Joe V. Chakkalakal
- , Kieran M. Jones
- & Andrew S. Brack
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News & Views |
A healthy diet for stem cells
Understanding how a low calorie intake slows ageing could revolutionize the way that we treat age-related diseases. One potential key to such treatments could be to enhance the local environment of stem cells. See Article p.490
- Fresnida J. Ramos
- & Matt Kaeberlein
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Article |
The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche
In the Drosophila testis, IGF-II messenger RNA binding protein (Imp) is shown to promote stem-cell niche maintenance by stabilizing unpaired (upd) RNA; Imp levels decrease in the hub cells of older males, owing to regulation by the microRNA let-7.
- Hila Toledano
- , Cecilia D’Alterio
- & D. Leanne Jones
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Article |
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
In the mouse intestine, calorie restriction enhances the regenerative capacity of intestinal stem cells by reducing mTORC1 signalling in their Paneth cell niche.
- Ömer H. Yilmaz
- , Pekka Katajisto
- & David M. Sabatini
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Article |
Endothelial and perivascular cells maintain haematopoietic stem cells
The cellular sources of stem cell factor, a major haematopoietic stem cell (HSC) niche cytokine required for HSC maintenance, are identified.
- Lei Ding
- , Thomas L. Saunders
- & Sean J. Morrison
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Letter |
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Multipotent stem cells expressing Lgr5 are known to generate all cell types of the intestinal epithelium (enterocytes, goblet cells, Paneth cells and enteroendocrine cells). A new study shows that Paneth cells have an essential role for intestinal crypt and stem cell maintenance by supplying essential niche signals to the Lgr5-expressing cells.
- Toshiro Sato
- , Johan H. van Es
- & Hans Clevers
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Letter |
Hormonal control of the shoot stem-cell niche
- Zhong Zhao
- , Stig U. Andersen
- & Jan U. Lohmann
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Article |
Systemic signals regulate ageing and rejuvenation of blood stem cell niches
Age-associated changes in stem cell supportive niche cells are shown to deregulate normal haematopoiesis by causing haematopoietic stem cell dysfunction. Age-dependent defects in niche cells are systemically regulated and can be reversed by exposure to a young circulation or by neutralization of the conserved longevity regulator, insulin-like growth factor-1, in the marrow microenvironment.
- Shane R. Mayack
- , Jennifer L. Shadrach
- & Amy J. Wagers