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| Open AccessDedifferentiation maintains melanocyte stem cells in a dynamic niche
Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other self-renewing systems.
- Qi Sun
- , Wendy Lee
- & Mayumi Ito
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Article |
Gibbin mesodermal regulation patterns epithelial development
Characterization of Gibbin, encoded by AHDC1, offers insights into the epidermal and mesodermal patterning phenotypes seen in Xia–Gibbs and related syndromes in humans, which derive from abnormal mesoderm maturation as a result of gene-specific DNA methylation decisions.
- Ann Collier
- , Angela Liu
- & Anthony E. Oro
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Article |
Obesity accelerates hair thinning by stem cell-centric converging mechanisms
Obesity in mice, caused by a high-fat diet, induces hair loss as a result of changes in the differentiation of hair follicle stem cells.
- Hironobu Morinaga
- , Yasuaki Mohri
- & Emi K. Nishimura
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Article |
Tracing the origin of hair follicle stem cells
Live imaging and single-cell transcriptomics of mouse hair follicles reveal their development from 2D concentric zones in the placode to 3D longitudinal compartments, one of which is a stem cell compartment.
- Ritsuko Morita
- , Noriko Sanzen
- & Hironobu Fujiwara
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Article |
Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Stress inhibits hair growth in mice through the release of the stress hormone corticosterone from the adrenal glands, which inhibits the activation of hair follicle stem cells by suppressing the expression of a secreted factor, GAS6, from the dermal niche.
- Sekyu Choi
- , Bing Zhang
- & Ya-Chieh Hsu
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Article |
Mechanisms of stretch-mediated skin expansion at single-cell resolution
Single-cell analysis in a mouse model of skin stretching shows that stretching causes a transient expansion bias in a population of epidermal stem cells, which is associated with chromatin remodelling and changes in transcriptional profiles.
- Mariaceleste Aragona
- , Alejandro Sifrim
- & Cédric Blanpain
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Article |
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells
Stress induces hair greying in mice through depletion of melanocyte stem cells, which is mediated by the activation of sympathetic nerves rather than through immune attack or adrenal stress hormones.
- Bing Zhang
- , Sai Ma
- & Ya-Chieh Hsu
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Letter |
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Signalling between the transcription factor IRF6 and the kinase RIPK4, in particular the phosphorylation of IRF6 by RIPK4, regulates epidermal differentiation and lipid metabolism, thereby maintaining the function of the epidermal barrier.
- Nina Oberbeck
- , Victoria C. Pham
- & Vishva M. Dixit
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Article |
Distinct modes of cell competition shape mammalian tissue morphogenesis
Cell competition in the developing mouse epithelium involves apoptosis and engulfment when the epithelium has only one layer, but switches to involve asymmetric cell division and differentiation of ‘loser’ cells as the epithelium becomes stratified.
- Stephanie J. Ellis
- , Nicholas C. Gomez
- & Elaine Fuchs
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Article |
Stem cell competition orchestrates skin homeostasis and ageing
COL17A1-driven stem cell competition and symmetric cell divisions initially govern skin homeostasis, but the same mechanisms result in skin ageing later in life.
- Nan Liu
- , Hiroyuki Matsumura
- & Emi K. Nishimura
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Letter |
An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis
Loss of the ribosome-rescue factor Pelo in a subset of mouse epidermal stem cells results in hyperproliferation and altered differentiation of these cells.
- Kifayathullah Liakath-Ali
- , Eric W. Mills
- & Fiona M. Watt
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Article |
Inflammatory memory sensitizes skin epithelial stem cells to tissue damage
After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.
- Shruti Naik
- , Samantha B. Larsen
- & Elaine Fuchs
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Letter |
Correction of aberrant growth preserves tissue homeostasis
Intravital imaging reveals unanticipated plasticity of adult skin epithelium in mice when faced with mutational or non-mutational insults, and elucidates the dynamic cellular behaviours used for its return to a homeostatic state.
- Samara Brown
- , Cristiana M. Pineda
- & Valentina Greco
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Article |
Stem cell function and stress response are controlled by protein synthesis
The protein translation rate is low in tissue stem cells and tumour-initiating cells, and genetically preventing cytosine-5 methylation on transfer RNA in skin tumours is shown to favour the maintenance of a state of translational inhibition in mice, with tumour-initiating cells in this state becoming more sensitive to cytotoxic stress.
- Sandra Blanco
- , Roberto Bandiera
- & Michaela Frye
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Letter |
Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool
Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.
- Kailin R. Mesa
- , Panteleimon Rompolas
- & Valentina Greco
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Letter |
Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice
An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.
- Rene C. Adam
- , Hanseul Yang
- & Elaine Fuchs
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Letter |
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Fibroblasts constitute the major mesenchymal cell type in the connective tissue and their functions are remarkably diverse: here, by characterising lineages of mouse skin fibroblasts, it is shown that distinct subpopulations contribute to skin development and repair during injury.
- Ryan R. Driskell
- , Beate M. Lichtenberger
- & Fiona M. Watt
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Letter |
NFIB is a governor of epithelial–melanocyte stem cell behaviour in a shared niche
NFIB, a transcription factor expressed by epithelial hair follicle stem cells, is shown to coordinate the synchronous maturation of hair follicle stem cells and melanocyte stem cells, thus controlling hair regeneration and pigmentation.
- Chiung-Ying Chang
- , H. Amalia Pasolli
- & Elaine Fuchs
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News & Views |
Dormant and restless skin stem cells
It has been unclear whether a uniform group of stem cells gives rise to most cells in the epidermis. A study reveals the presence of at least two stem-cell populations that have different proliferative abilities. See Article p.257
- Laura De Rosa
- & Michele De Luca
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Article |
Distinct contribution of stem and progenitor cells to epidermal maintenance
Whether a single group of stem cells or multiple populations contribute to the homeostasis of the interfollicular epidermis is controversial; here the authors use lineage tracing and mathematical modelling to show that the progenitors that maintain mouse epidermis are underpinned by slow-cycling stem cells that become mobilized on injury.
- Guilhem Mascré
- , Sophie Dekoninck
- & Cédric Blanpain
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News |
Mutant stem cells can cause skin cancer at cuts
Cells meant to fix injuries can trigger tumours in cancer-prone mice.
- Erika Check Hayden
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News & Views |
Skin regeneration and repair
Different types of stem cell maintain the skin's epidermis and contribute to its healing after damage. The identity of a stem-cell type that gives rise to different epidermal-cell lineages has just been revealed.
- Cédric Blanpain