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Featured
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Article |
Lysine catabolism reprograms tumour immunity through histone crotonylation
Glioblastoma stem cells co-opt lysine uptake and degradation to shunt the production of crotonyl-CoA, remodelling the chromatin landscape to evade interferon-induced intrinsic effects on glioblastoma stem cell maintenance and extrinsic effects on immune response.
- Huairui Yuan
- , Xujia Wu
- & Jeremy N. Rich
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Article |
A phosphate-sensing organelle regulates phosphate and tissue homeostasis
PXo bodies, non-canonical multilamellar organelles, serve as a reservoir for intracellular inorganic phosphate and are a critical regulator of both cytosolic phosphate levels and tissue homeostasis.
- Chiwei Xu
- , Jun Xu
- & Norbert Perrimon
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News & Views |
Yo-yoing stem cells defy dogma to maintain hair colour
The observation that melanocyte stem cells migrate up and down the hair follicle, differentiating into melanocytes and then returning to a stem-cell identity, calls into question long-held assumptions about adult stem cells.
- Carlos Galvan
- & William E. Lowry
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Article
| Open AccessDedifferentiation maintains melanocyte stem cells in a dynamic niche
Local microenvironmental cues modulate melanocyte stem cells, which control hair pigmentation, to enter different differentiation states, shifting between hair follicle stem cell and transit-amplifying compartments, a process that is different to other self-renewing systems.
- Qi Sun
- , Wendy Lee
- & Mayumi Ito
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Article |
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis
Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.
- Joshua S. Weinstock
- , Jayakrishnan Gopakumar
- & Siddhartha Jaiswal
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News |
Stem-cell-derived ‘embryos’ implanted in monkeys
An embryo-like ball of cells offers a way to study pregnancy and its complications without the typical ethical dilemmas.
- Gemma Conroy
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News & Views |
Eggs made from male mouse stem cells using error-prone culture
A screen of mouse stem cells that exploits their propensity to gain or lose chromosomes in cell culture has been used to convert male XY to female XX cells. Subsequent differentiation generates functional eggs and live offspring.
- Jonathan Bayerl
- & Diana J. Laird
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Article |
Generation of functional oocytes from male mice in vitro
Mouse induced pluripotent stem cells derived from differentiated fibroblasts could be converted from male (XY) to female (XX), resulting in cells that could form oocytes and give rise to offspring after fertilization.
- Kenta Murakami
- , Nobuhiko Hamazaki
- & Katsuhiko Hayashi
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Outlook |
How organoids are advancing the understanding of chronic kidney disease
Although complete human kidneys grown from scratch are many years away, organoids built from pluripotent stem cells are already helping to model the condition and suggest better treatments.
- Eric Bender
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Research Highlight |
Mice grow ‘mini-antlers’ thanks to deers’ speedy stem cells
The cells regenerate masses of bone and cartilage every year.
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Article |
Chemically defined cytokine-free expansion of human haematopoietic stem cells
A culture system allows the long-term expansion of human haematopoietic stem cells (HSCs) in vivo without the use of recombinant cytokines or albumin, with potential applications for clinical therapies involving HSCs.
- Masatoshi Sakurai
- , Kantaro Ishitsuka
- & Satoshi Yamazaki
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Nature Careers Podcast |
Leadership in science: “There is nothing wrong with being wrong”
Science is in good shape when its leaders can acknowledge things that go wrong, says Fiona Watt.
- Julie Gould
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Research Highlight |
Supreme regenerative skills help sea spiders to regrow guts and more
Other arthropods can regrow lost legs, but the sea spider can regenerate central organs all the way to the anus.
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Article |
Functional T cells are capable of supernumerary cell division and longevity
Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.
- Andrew G. Soerens
- , Marco Künzli
- & David Masopust
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Research Briefing |
Structural landscape inside cells mapped in detail
More than 200,000 human stem cells were imaged at high resolution and in 3D to make a reference data set that was used to create a generalizable computational framework. This enables cell shapes and the locations of internal structures to be measured and compared using rigorous statistical methods.
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Article
| Open AccessIntegrated intracellular organization and its variations in human iPS cells
A dataset of 3D images from more than 200,000 human induced pluripotent stem cells is used to develop a framework to analyse cell shape and the location and organization of major intracellular structures.
- Matheus P. Viana
- , Jianxu Chen
- & Susanne M. Rafelski
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Research Highlight |
Toes regrow with the help of these cells
Cells at the base of the nail are key to regeneration of missing digit tips.
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Nature Video |
‘Artificial embryos’: the hidden steps in forming a spine
New models called axioloids offer insight into development of vertebrae in humans.
- Dan Fox
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News & Views |
Senescent cells damage the body throughout life
Cells in a state of arrested growth, called senescence, have been characterized in skeletal muscle in mice. Senescent cells promote inflammation and block regeneration, and thus might induce harmful changes in aged muscle.
- David J. Glass
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Article |
Reconstruction and deconstruction of human somitogenesis in vitro
Somitoids and segmentoids—culture systems that recapitulate the formation of somite-like structures—reveal that an initial salt-and-pepper expression pattern of MESP2 in a newly formed segment is transformed into compartments of anterior and posterior identity through an active cell-sorting mechanism.
- Yuchuan Miao
- , Yannis Djeffal
- & Olivier Pourquié
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Article
| Open AccessSenescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
A lifetime cartography of in vivo senescent cells shows that they are heterogeneous. Senescent cells create an aged-like inflamed niche that mirrors inflammation associated with ageing and arrests stem cell proliferation and tissue regeneration.
- Victoria Moiseeva
- , Andrés Cisneros
- & Pura Muñoz-Cánoves
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Article |
Reconstituting human somitogenesis in vitro
A 3D model of human segmentation and somitogenesis derived from induced pluripotent stem cells captures the oscillatory dynamics of the segmentation clock as well as morphological and molecular features of the developing embryonic axis and tail.
- Yoshihiro Yamanaka
- , Sofiane Hamidi
- & Cantas Alev
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Research Briefing |
Plant-cell machinery for making metabolites transferred to mammalian cells
Supplies of the crucial molecules ATP and NADPH are lacking in many human diseases, but restoring them requires tight control. Using light-powered thylakoid structures from plants to carefully deliver these molecules to the joints of arthritic mice slowed degeneration.
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News & Views |
Neurons that promote recovery from paralysis identified
Improved treatments for spinal-cord injury require both technological development and insights into the biology of recovery. High-resolution molecular maps of the nervous system are beginning to provide the latter.
- Kee Wui Huang
- & Eiman Azim
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News |
Human brain cells implanted in rats prompt excitement — and concern
Rat–human hybrid brains offer new ways to study human neurological disorders, but also raise ethical questions.
- Sara Reardon
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Article
| Open AccessInferring and perturbing cell fate regulomes in human brain organoids
A multi-omic atlas of brain organoid development facilitates the inference of an underlying gene regulatory network using the newly developed Pando framework and shows—in conjunction with perturbation experiments—that GLI3 controls forebrain fate establishment through interaction with HES4/5 regulomes.
- Jonas Simon Fleck
- , Sophie Martina Johanna Jansen
- & Barbara Treutlein
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News & Views |
Mouse embryo models built from stem cells take shape in a dish
Two groups have grown self-organizing models of mouse embryos from stem cells in vitro. The models mimic mid-gestation embryos, providing an unparalleled opportunity to study early embryonic development.
- Neal D. Amin
- & Sergiu P. Pașca
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Article |
Independent origins of fetal liver haematopoietic stem and progenitor cells
In fetal liver, the structure of the differentiated haemapoietic progenitor cell population is established directly from precursor cells, independently of haemapoietic stem cells.
- Tomomasa Yokomizo
- , Takako Ideue
- & Toshio Suda
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Nature Podcast |
Audio long read: Hybrid brains – the ethics of transplanting human neurons into animals
Human cells transplanted into animal brains provide insights into development and disease but also raise ethical questions.
- Kendall Powell
- & Benjamin Thompson
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Article
| Open AccessEmbryo model completes gastrulation to neurulation and organogenesis
Synthetic mouse embryos assembled from embryonic stem cells, trophoblast stem cells and induced extraembryonic endoderm stem cells closely recapitulate the development of wild-type and mutant natural mouse embryos up to embryonic day 8.5.
- Gianluca Amadei
- , Charlotte E. Handford
- & Magdalena Zernicka-Goetz
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News |
Pioneering stem-cell trials in Japan report promising early results
The country has invested hundreds of millions of dollars into research on induced pluripotent stem cells to treat diseased organs.
- Smriti Mallapaty
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News Feature |
Hybrid brains: the ethics of transplanting human neurons into animals
Transplanting human cells into animal brains brings insights into development and disease along with new ethical questions.
- Kendall Powell
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News |
Pig organs partially revived in dead animals — researchers are stunned
Scientists warn that the findings aren’t yet clinically relevant but say the research raises ethical questions about the definition of death.
- Max Kozlov
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News & Views |
Relocation sustains intestinal stem-cell numbers
A dynamic mode of stem-cell regulation has been discovered. Intestinal stem cells use migration to maintain a large pool of multifunctional cells, perhaps endowing the organ with robust responses to injury.
- Stephanie J. Ellis
- & Elaine Fuchs
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Article |
Retrograde movements determine effective stem cell numbers in the intestine
Small intestinal crypts contain twice as many effective stem cells as large intestinal crypts, and this difference is determined by the degree of Wnt-driven retrograde cell movement—which is largely absent in the large intestine—counteracting conveyor-belt-like upward movement.
- Maria Azkanaz
- , Bernat Corominas-Murtra
- & Jacco van Rheenen
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Review Article |
Inflammatory memory and tissue adaptation in sickness and in health
A Review on inflammatory memory in non-immune cells of different epithelia and neurons, and the potential mechanisms controlling these epigenetic memories and their implications in human health and disease.
- Shruti Naik
- & Elaine Fuchs
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Article |
Induction of mouse totipotent stem cells by a defined chemical cocktail
Under chemically defined conditions, mouse pluripotent stem cells can be induced to closely resemble authentic totipotent stem cells that can differentiate to both embryonic and extraembryonic lineages.
- Yanyan Hu
- , Yuanyuan Yang
- & Sheng Ding
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Article |
Spatial profiling of early primate gastrulation in utero
3D transcriptomes reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.
- Sophie Bergmann
- , Christopher A. Penfold
- & Thorsten E. Boroviak
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Article |
Lifelong multilineage contribution by embryonic-born blood progenitors
In situ barcoding and fate mapping in mice reveals that an early wave of progenitor specification, driven by embryonic multipotent progenitor cells, gives rise to adult blood independently of haematopoietic stem cells.
- Sachin H. Patel
- , Constantina Christodoulou
- & Fernando D. Camargo
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News & Views |
Blood’s life history traced through genomic scars
Two studies of the mutations acquired by blood-forming cells over time provide insights into the dynamics of blood production in humans and its relationship to ageing.
- Aswin Sekar
- & Benjamin L. Ebert
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Article
| Open AccessClonal dynamics of haematopoiesis across the human lifespan
Haematopoiesis has high clonal diversity up to about 65 years of age, after which diversity drops precipitously owing to positive selection acting on a handful of clones that expand exponentially throughout adulthood.
- Emily Mitchell
- , Michael Spencer Chapman
- & Peter J. Campbell
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News & Views |
Nerve regrowth can be painful
Neuronal fibres have been tracked as they regrow into the skin following nerve injury in mice. The analysis reveals that mis-wiring of pain-sensing fibres generates hypersensitivity to touch in skin associated with the injury.
- Suna L. Cranfill
- & Wenqin Luo
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Article |
Gibbin mesodermal regulation patterns epithelial development
Characterization of Gibbin, encoded by AHDC1, offers insights into the epidermal and mesodermal patterning phenotypes seen in Xia–Gibbs and related syndromes in humans, which derive from abnormal mesoderm maturation as a result of gene-specific DNA methylation decisions.
- Ann Collier
- , Angela Liu
- & Anthony E. Oro
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Article |
Generation of 3D lacrimal gland organoids from human pluripotent stem cells
Organoids originating from human multipotent ocular surface epithelial stem cells are similar to native lacrimal glands and undergo functional maturation when transplanted adjacent to the eyes of recipient rats, developing lumina and producing tear-film proteins.
- Ryuhei Hayashi
- , Toru Okubo
- & Kohji Nishida
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Article |
Chemical reprogramming of human somatic cells to pluripotent stem cells
Human somatic cells were reprogrammed to human chemically induced pluripotent stem cells that demonstrate key features of embryonic stem cells.
- Jingyang Guan
- , Guan Wang
- & Hongkui Deng
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Article |
Mapping human haematopoietic stem cells from haemogenic endothelium to birth
The HSC signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguishes haematopoietic stem cells from their endothelial precursors and differentiated progenitors throughout ontogeny
- Vincenzo Calvanese
- , Sandra Capellera-Garcia
- & Hanna K. A. Mikkola
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Article |
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
Spatial transcriptomics and single-cell profiling identify previously uncharacterized cell types of human terminal and respiratory bronchioles, and show that cell differentiation and lineage trajectories are distinct from those in the mouse lung.
- Preetish Kadur Lakshminarasimha Murthy
- , Vishwaraj Sontake
- & Purushothama Rao Tata
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Article |
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Human respiratory bronchioles contain a unique population of secretory cells called respiratory airway secretory cells that are distinct from the cells in the larger proximal airways, and act as unidirectional progenitors for alveolar type 2 cells.
- Maria C. Basil
- , Fabian L. Cardenas-Diaz
- & Edward E. Morrisey
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Article |
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
The development of a transgene-free, rapid and controllable method for producing eight-cell-like cells from human pluripotent stem cells provides a valuable resource to study early human embryogenesis.
- Md. Abdul Mazid
- , Carl Ward
- & Miguel A. Esteban
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