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Molecular biology

A hidden competitive advantage of disorder

Nature volume 543, pages 325–326 (2017)Cite this article

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The cellular response to low oxygen levels is regulated by a process in which one protein is ousted from a binding site by another. It emerges that protein disorder allows the displacement to occur remarkably efficiently. See Letter p.447

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Figure 1: Efficient displacement of a protein from a binding site.

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Authors and Affiliations

  1. P. Andrew Chong and Julie D. Forman-Kay are in the Program in Molecular Medicine, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.,

    P. Andrew Chong & Julie D. Forman-Kay

  2. J.D.F.-K. is also in the Biochemistry Department, University of Toronto.,

    Julie D. Forman-Kay

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  1. P. Andrew Chong
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  2. Julie D. Forman-Kay
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Correspondence to Julie D. Forman-Kay.

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Structural biology: Signalling from disordered proteins

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Chong, P., Forman-Kay, J. A hidden competitive advantage of disorder. Nature 543, 325–326 (2017). https://doi.org/10.1038/nature21893

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