Featured
-
-
Article
| Open AccessObject representations in the human brain reflect the co-occurrence statistics of vision and language
When people view an object, they can often guess the setting from which it was drawn and the other objects that might be found in that setting. Here the authors identify regions of the human visual system that represent this information about which objects tend to appear together in the world.
- Michael F. Bonner
- & Russell A. Epstein
-
Article
| Open AccessMouse visual cortex contains a region of enhanced spatial resolution
The representation of space in mouse visual cortex was considered to be relatively uniform. The authors show that mice have improved visual resolution in a cortical region representing a location in space directly in front and slightly above them, showing that the representation of space in mouse visual cortex is non-uniform.
- Enny H. van Beest
- , Sreedeep Mukherjee
- & Matthew W. Self
-
Article
| Open AccessAnalysis of gene network bifurcation during optic cup morphogenesis in zebrafish
The gene regulatory network controlling the bifurcation of common progenitors into the neural retina and retinal-pigmented epithelium programs remains poorly understood. Here the authors study transcriptome dynamics and chromatin accessibility during this process in zebrafish, revealing network redundancy, as well as context-dependent and sequential transcription factor activity.
- Lorena Buono
- , Jorge Corbacho
- & Juan-Ramón Martínez-Morales
-
Article
| Open AccessNeuronal variability reflects probabilistic inference tuned to natural image statistics
The neural sampling theory suggests that neuronal variability encodes the uncertainty of probabilistic inferences. This paper shows that response variability in primary visual cortex reflects the statistical structure of visual inputs, as required for inferences correctly tuned to the statistics of the natural environment.
- Dylan Festa
- , Amir Aschner
- & Ruben Coen-Cagli
-
Article
| Open AccessTopographic numerosity maps cover subitizing and estimation ranges
Here, the authors show that the brain represents small and large numerosity ranges in a continuous topographic map, in line with the idea that differences in map properties underlie differences in perception.
- Yuxuan Cai
- , Shir Hofstetter
- & Serge O. Dumoulin
-
Article
| Open AccessCortical and subcortical signatures of conscious object recognition
Cortical and subcortical neural activity supporting conscious object recognition has not yet been well defined. Here, the authors describe these networks and show recognition-related category information can be decoded from widespread cortical activity but not subcortical activity.
- Max Levinson
- , Ella Podvalny
- & Biyu J. He
-
Article
| Open AccessA network linking scene perception and spatial memory systems in posterior cerebral cortex
Navigation requires integration of visual information with spatial memory representations. Steel et al. describe a new network of brain areas that facilitates the interaction between these perceptual and mnemonic neural systems.
- Adam Steel
- , Madeleine M. Billings
- & Caroline E. Robertson
-
Article
| Open AccessChromatic micromaps in primary visual cortex
Stimulus feature maps are found in primary visual cortex of many species. Here the authors show color maps in trichromatic primates containing segregated ensembles of neurons with distinct chromatic signatures that associate with cortical modules known as blobs.
- Soumya Chatterjee
- , Kenichi Ohki
- & R. Clay Reid
-
Article
| Open AccessDifferential spatial computations in ventral and lateral face-selective regions are scaffolded by structural connections
Humans process faces using face-selective regions in the ventral and lateral streams which perform different tasks. Here, the authors show via functional and diffusion MRI that the spatial computations in face-selective regions vary across streams, constrained by connections from early visual areas.
- Dawn Finzi
- , Jesse Gomez
- & Kalanit Grill-Spector
-
Article
| Open AccessLimits to visual representational correspondence between convolutional neural networks and the human brain
Convolutional neural networks are increasingly used to model human vision. Here, the authors compare the performance of 14 different CNNs and human fMRI responses to real-world and artificial objects to show some fundamental differences exist between them.
- Yaoda Xu
- & Maryam Vaziri-Pashkam
-
Article
| Open AccessSingle trial neuronal activity dynamics of attentional intensity in monkey visual area V4
How intensely an individual focuses attention is a fundamental component of attention in improving behavior performance. Here, the authors isolated neuronal activity dynamics in visual cortex V4 that represents the intensive aspect of attention independent of selective attention and experimental covariates- reward expectation, motor response preparation.
- Supriya Ghosh
- & John H. R. Maunsell
-
Article
| Open AccessLinear and nonlinear chromatic integration in the mouse retina
This study shows that ganglion cells in mouse retina integrate chromatic visual signals either linearly or nonlinearly. Nonlinear chromatic integration depends on rod photoreceptor activity and on surround inhibition and may help detect chromatic boundaries, such as the skyline in natural scenes.
- Mohammad Hossein Khani
- & Tim Gollisch
-
Article
| Open AccessQualitative similarities and differences in visual object representations between brains and deep networks
Deep neural networks are widely considered as good models for biological vision. Here, we describe several qualitative similarities and differences in object representations between brains and deep networks that elucidate when deep networks can be considered good models for biological vision and how they can be improved.
- Georgin Jacob
- , R. T. Pramod
- & S. P. Arun
-
Article
| Open AccessDynamics of fMRI patterns reflect sub-second activation sequences and reveal replay in human visual cortex
Non-invasive measurement of fast neural activity with spatial precision in humans is difficult. Here, the authors show how fMRI can be used to detect sub-second neural sequences in a localized fashion and report fast replay of images in visual cortex that occurred independently of the hippocampus.
- Lennart Wittkuhn
- & Nicolas W. Schuck
-
Article
| Open AccessRapid multi-directed cholinergic transmission in the central nervous system
Cholinergic neurons may transmit information via fast synaptic, point-to-point signaling or diffuse, slow extra-synaptic signaling. The authors show that ACh from a single vesicle triggers synchronous miniature currents in two neurons, showing that ACh can spread significant distances to drive rapid ‘synaptic’ signals.
- Santhosh Sethuramanujam
- , Akihiro Matsumoto
- & Gautam B. Awatramani
-
Article
| Open AccessCausal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation
Learning-activated engram neurons play a critical role in memory recall but the role of these neurons in offline memory consolidation is unclear. The authors show that sleep-associated reactivation of learning-activated sensory neurons is necessary for memory consolidation.
- Brittany C. Clawson
- , Emily J. Pickup
- & Sara J. Aton
-
Article
| Open AccessHost interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex
Transplantation of embryonic interneurons can restore juvenile plasticity to the adult host visual cortex. Here, the authors show that transplanted embryonic interneurons reactivate cortical plasticity via Neuregulin/ErbB4 signaling in host parvalbumin interneurons.
- XiaoTing Zheng
- , Kirstie J. Salinas
- & Sunil P. Gandhi
-
Article
| Open AccessScaling of sensory information in large neural populations shows signatures of information-limiting correlations
Information regarding a sensory stimulus is distributed in activity of neuronal populations. Here the authors show stimulus information scales sub-linearly with the number of neurons in mouse visual cortex due to correlated noise and may saturate in far fewer numbers of neurons than the total in V1.
- MohammadMehdi Kafashan
- , Anna W. Jaffe
- & Jan Drugowitsch
-
Article
| Open AccessTime-frequency super-resolution with superlets
Identifying the frequency, temporal location, duration, and amplitude of finite oscillation packets in neurophysiological signals with high precision is challenging. The authors present a method based on multiple wavelets to improve the detection of localized time-frequency packets.
- Vasile V. Moca
- , Harald Bârzan
- & Raul C. Mureșan
-
Article
| Open AccessStream-specific feedback inputs to the primate primary visual cortex
In the primate cortex, visual images are processed by multiple hierarchically-organized areas reciprocally connected via feedforward and feedback circuits. Here the authors show that feedback circuits are organized into segregated parallel streams that resemble feedforward pathways.
- Frederick Federer
- , Seminare Ta’afua
- & Alessandra Angelucci
-
Article
| Open AccessUniform spatial pooling explains topographic organization and deviation from receptive-field scale invariance in primate V1
Two-photon imaging in macaque V1 captured maps of tuning selectivity for four spatial parameters, all of which correlated with peak spatial frequency. These inter-map relationships reveal a common motif—they are described by uniform spatial pooling from a family of scale invariant Gabor receptive fields.
- Y. Chen
- , H. Ko
- & I. Nauhaus
-
Article
| Open AccessPerceptually unidentifiable stimuli influence cortical processing and behavioral performance
Perceptually unidentifiable stimuli are encoded in the visual cortex, such as to facilitate their future processing in a task context. This form of priming may constitute a pre-attention mechanism using the mere frequency of stimulus occurrence to change stimulus representations, even when sensory inputs are perceptually invisible.
- Sorin A. Pojoga
- , Natasha Kharas
- & Valentin Dragoi
-
Article
| Open AccessFace selective patches in marmoset frontal cortex
In Old World primates, socially relevant face processing is accomplished via a distributed functional network including specialized patches in the frontal cortex. Here, the authors demonstrate a similar network in frontal cortex of New World marmoset monkeys, suggesting inheritance from a common ancestor.
- David J. Schaeffer
- , Janahan Selvanayagam
- & Stefan Everling
-
Article
| Open AccessIgnoring correlated activity causes a failure of retinal population codes
To see during day and night, the retina adapts to a trillion-fold change in light intensity. The authors show that an accurate read-out of retinal signals over this intensity range requires that brain circuits account for changing noise correlations across populations of retinal neurons.
- Kiersten Ruda
- , Joel Zylberberg
- & Greg D. Field
-
Article
| Open AccessAccelerating eye movement research via accurate and affordable smartphone eye tracking
Progress in eye movement research has been limited since existing eye trackers are expensive and do not scale. Here, the authors show that smartphone-based eye tracking achieves high accuracy comparable to state-of-the-art mobile eye trackers, replicating key findings from prior eye movement research.
- Nachiappan Valliappan
- , Na Dai
- & Vidhya Navalpakkam
-
Article
| Open AccessRapid and dynamic processing of face pareidolia in the human brain
The human brain is specialised for face processing, yet sometimes objects are perceived as illusory faces. Here, the authors show that illusory faces are initially represented similarly to real faces, but the representation quickly transforms into one equivalent to ordinary objects.
- Susan G. Wardle
- , Jessica Taubert
- & Chris I. Baker
-
Article
| Open AccessEndogenous activity modulates stimulus and circuit-specific neural tuning and predicts perceptual behavior
Endogenous brain states influence perception. In this manuscript the authors use human intracranial recordings to provide mechanistic insight into this process by showing that endogenous brain activity facilitates neural tuning and behavior in a stimulus and circuit specific manner.
- Yuanning Li
- , Michael J. Ward
- & Avniel Singh Ghuman
-
Article
| Open AccessThe inferior temporal cortex is a potential cortical precursor of orthographic processing in untrained monkeys
The neuronal mechanisms underlying recognition of written letters remain unknown. Here, the authors show that populations of neurons in the ventral visual pathway of macaque monkeys encode orthographic stimuli, indicating that this pathway might be a precursor of orthographic processing abilities.
- Rishi Rajalingham
- , Kohitij Kar
- & James J. DiCarlo
-
Article
| Open AccessDistributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex
Processing of coherent motion has been extensively studied in the primate visual system, but has not been well characterized in mice. Here, the authors use widefield calcium imaging to reveal that coherent motion responses are organized anisotropically both across and within visual areas in mice.
- Kevin K. Sit
- & Michael J. Goard
-
Article
| Open AccessNeural circuits in the mouse retina support color vision in the upper visual field
Mice are able to discriminate colors, at least in the upper visual field. Here, the authors provide a comprehensive characterization of retinal circuits underlying this behavior.
- Klaudia P. Szatko
- , Maria M. Korympidou
- & Katrin Franke
-
Article
| Open AccessOrbitofrontal control of visual cortex gain promotes visual associative learning
The orbitofrontal cortex (OFC) encodes expected outcomes and plays a key role in outcome-guided behavior. The authors show here that the top-down projection from the OFC to the visual cortex drives visual associative learning by modulating the response gain of V1 neurons to non-relevant stimuli.
- Dechen Liu
- , Juan Deng
- & Haishan Yao
-
Article
| Open AccessWeaker neural suppression in autism
Sensory hypersensitivity is common in autism spectrum disorders. Using functional MRI, psychophysics, and computational modeling, Schallmo et al. show that differences in visual motion perception in ASD are accompanied by weaker neural suppression in visual cortex.
- Michael-Paul Schallmo
- , Tamar Kolodny
- & Scott O. Murray
-
Article
| Open AccessRepresentation of visual uncertainty through neural gain variability
How does the brain represent sensory uncertainty? The authors find that neural gain variability tracks stimulus uncertainty across the visual hierarchy and explain their findings with a simple generalization of canonical models of neural computation.
- Olivier J. Hénaff
- , Zoe M. Boundy-Singer
- & Robbe L. T. Goris
-
Article
| Open AccessAttention amplifies neural representations of changes in sensory input at the expense of perceptual accuracy
We allocate attention to relevant sensory stimuli to enhance their neural processing. Here, the authors show that attention, like adaptation, causes a misrepresentation and misperception of visual changes in our environment in cases where this aids the perceptual task at hand.
- Vahid Mehrpour
- , Julio C. Martinez-Trujillo
- & Stefan Treue
-
Article
| Open AccessType-specific dendritic integration in mouse retinal ganglion cells
Neurons compute by integrating synaptic inputs across their dendritic arbor. Here, the authors show that distinct cell-types of mouse retinal ganglion cells that receive similar excitatory inputs have different biophysical mechanisms of input integration to generate their unique response tuning.
- Yanli Ran
- , Ziwei Huang
- & Thomas Euler
-
Article
| Open AccessEndogenous and exogenous control of visuospatial selective attention in freely behaving mice
The authors describe behavioural tasks for the study of primate-like, endogenous and exogenous control of visuospatial selective attention in freely behaving mice.
- Wen-Kai You
- & Shreesh P. Mysore
-
Article
| Open AccessPerceptual saccadic suppression starts in the retina
Saccadic suppression is frequently attributed to active suppressive signals derived from eye movement commands. Here, the authors show that visual-only mechanisms starting in the retina can account for perceptual saccadic suppression properties without the need for motor-based suppression commands.
- Saad Idrees
- , Matthias P. Baumann
- & Ziad M. Hafed
-
Article
| Open AccessContext information supports serial dependence of multiple visual objects across memory episodes
Visual cognition compensates for small changes in an object’s appearance to ensure its perceived continuity. We show that in situations with multiple objects, context features like color, temporal or spatial position are used as anchors to selectively integrate corresponding objects over time.
- Cora Fischer
- , Stefan Czoschke
- & Christoph Bledowski
-
Article
| Open AccessImpact of visual callosal pathway is dependent upon ipsilateral thalamus
The visual callosal pathway reciprocally connects mammalian visual cortices and is proposed to facilitate activation of binocular neurons. Here, the authors show that this pathway facilitates responses in both monocular and binocular neurons but these responses are gated by the ipsilateral lateral geniculate nucleus.
- Vishnudev Ramachandra
- , Verena Pawlak
- & Jason N. D. Kerr
-
Article
| Open AccessSpatial contextual effects in primary visual cortex limit feature representation under crowding
Visual crowding can strongly limit perceptual discriminability, yet its neural basis remains unclear. Here, the authors show that perceptual crowding is similar in monkeys and humans, and that feature encoding in neuronal populations in primary visual cortex is limited for displays inducing crowding.
- Christopher A. Henry
- & Adam Kohn
-
Article
| Open AccessOptogenetic restoration of retinal ganglion cell activity in the living primate
Non-human primate models are important for the development of high quality vision restoration therapies for blindness. Here, the authors demonstrate restoration of light responses in foveal retinal ganglion cells of the living macaque following optogenetic gene therapy.
- Juliette E. McGregor
- , Tyler Godat
- & William H. Merigan
-
Article
| Open AccessOpen access resource for cellular-resolution analyses of corticocortical connectivity in the marmoset monkey
Understanding principles of neuronal connectivity requires tools for quantification and visualization of large datasets. Here, the authors introduce an online resource encompassing the coordinates of two million neurons labelled by tracer injections in the marmoset cortex, and analysis tools.
- Piotr Majka
- , Shi Bai
- & Marcello G. P. Rosa
-
Article
| Open AccessA segregated cortical stream for retinal direction selectivity
Visual features are streamed into higher visual areas (HVAs), but how representations in HVAs are built, based on retinal output channels, is unknown. Here, the authors show that specific connectivity of cortical neurons routes retina-originated direction-selective signaling into distinct HVAs.
- Rune Rasmussen
- , Akihiro Matsumoto
- & Keisuke Yonehara
-
Article
| Open AccessFinely tuned eye movements enhance visual acuity
Humans are normally not aware that their eyes are always in motion, even when attempting to maintain steady gaze on a point. Here the authors show that these small eye movements are finely controlled and contribute more than two lines in a standard eye-chart test of visual acuity.
- Janis Intoy
- & Michele Rucci
-
Article
| Open AccessGenetic influence is linked to cortical morphology in category-selective areas of visual cortex
It remains unclear whether the functional organization of the visual cortex is shaped by genetic or environmental factors. Using fMRI in twins (n = 424), these authors show that activation patterns in category-selective areas are heritable, and that the genetic effects in these areas are linked to structural properties of cortical tissue.
- Nooshin Abbasi
- , John Duncan
- & Reza Rajimehr
-
Article
| Open AccessSpatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons
The integration of synaptic inputs onto dendrites provides the basis for neuronal computation. Here the authors perform two-photon dendritic imaging with a genetically-encoded glutamate sensor in awake monkeys, and map the excitatory synaptic inputs on dendrites of individual V1 superficial layer neurons with high spatial and temporal resolution.
- Niansheng Ju
- , Yang Li
- & Shiming Tang
-
Article
| Open AccessSpatial attention enhances network, cellular and subthreshold responses in mouse visual cortex
Extensive research in primates shows that attention to space improves behavioural performance as well as neural responses to stimuli in that location. Here, the authors establish a visual spatial attention task in mice and report on attentional modulation of behaviour, as well as neural correlates from subthreshold responses in single cells to spikes and LFP at network level.
- Anderson Speed
- , Joseph Del Rosario
- & Bilal Haider
-
Article
| Open AccessThe role of prefrontal cortex in the control of feature attention in area V4
The neural mechanisms underlying feature based attention to targets in a cluttered scene are not well understood. Here, the authors show that inactivation of the ventral prearcuate region leads to deficits in picking out a target among many stimuli as well as eliminates the feature based modulation of responses of V4 neurons.
- Narcisse P. Bichot
- , Rui Xu
- & Robert Desimone
-
Article
| Open AccessAudio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
Sensory stimuli usually arrive simultaneously but the neural-circuit mechanisms that combine multiple streams of sensory information are incompletely understood. The authors here show that visual-auditory pairing drives plasticity in multi-modal neuron networks within the mouse visual cortex.
- Thomas Knöpfel
- , Yann Sweeney
- & Samuel J. Barnes