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Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase
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Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats
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Sulfation of sialic acid is ubiquitous and essential for vertebrate development
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Fatty acid tryptamide from cacao elongates Drosophila melanogaster lifespan with sirtuin-dependent heat shock protein expression
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Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production
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Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes
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Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1
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A simple method to measure sulfonation in man using paracetamol as probe drug
- Natália Marto
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Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril
- Benjamin J. Maldonato
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A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
- Anthony D. Verderosa
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Functional and computational identification of a rescue mutation near the active site of an mRNA methyltransferase
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Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
- Abbas H. K. Al Temimi
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Roles of two glutathione S-transferases in the final step of the β-aryl ether cleavage pathway in Sphingobium sp. strain SYK-6
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Functional characterisation of the transcriptome from leaf tissue of the fluoroacetate-producing plant, Dichapetalum cymosum, in response to mechanical wounding
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Insights into the structure and function of Est3 from the Hansenula polymorpha telomerase
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Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
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Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
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Effects of SDS on the activity and conformation of protein tyrosine phosphatase from thermus thermophilus HB27
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Identification and characterization of a bacterial core methionine synthase
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Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site
- Catherine T. Chaton
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Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
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Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1)
- Maria Elena Ortiz-Soto
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Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase
- Federica Ruggieri
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A sensitive fluorescence-based assay to monitor enzymatic activity of the essential integral membrane protein Apolipoprotein N-acyltransferase (Lnt)
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Population variability of rhesus macaque (Macaca mulatta) NAT1 gene for arylamine N-acetyltransferase 1: Functional effects and comparison with human
- Sotiria Boukouvala
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Cascade biotransformation of estrogens by Isaria fumosorosea KCh J2
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Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
- Jon G. Dean
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Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis
- Sanghyun Lee
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Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase
- Manchuta Dangkulwanich
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Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior
- Aline Robert-Hazotte
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Identification of non-specific Lipid Transfer Protein gene family members in Solanum lycopersicum and insights into the features of Sola l 3 protein
- Nunzio D’Agostino
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γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity
- Alessandro Corti
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The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties
- Jihen Ati
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Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus
- Rashmi Panigrahi
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Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium
- Xiao Wang
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The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes
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Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase
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Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis
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Molecular identification and characterization of rhodaneses from the insect herbivore Pieris rapae
- Anna-Maria Steiner
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Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues
- Theodora Tsirka
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Heterologous expression of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum rescues Chinese Hamster Ovary cells deficient in the Kennedy phosphatidylcholine biosynthesis pathway
- Lívia Marton
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Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine
- Sven Johannsson
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Molecular recognition of wood polyphenols by phase II detoxification enzymes of the white rot Trametes versicolor
- Mathieu Schwartz
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Isolation and characterization of a multifunctional flavonoid glycosyltransferase from Ornithogalum caudatum with glycosidase activity
- Shuai Yuan
- , Sen Yin
- & Jian-Qiang Kong
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Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
- Egor P. Tchesnokov
- , Parisa Raeisimakiani
- & Matthias Götte
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A Novel Mitochondrial Serine O-Acetyltransferase, OpSAT1, Plays a Critical Role in Sulfur Metabolism in the Thermotolerant Methylotrophic Yeast Ogataea parapolymorpha
- Ji Yoon Yeon
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Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives
- Gayan S. Jayawickrama
- , Alireza Nematollahi
- & W. Bret Church
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Lysophosphatidylcholine acyltransferase 4 is involved in chondrogenic differentiation of ATDC5 cells
- Shirou Tabe
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Structure–function analysis of histone H2B and PCNA ubiquitination dynamics using deubiquitinase-deficient strains
Dna is a New Target of Parp3