Transferases articles within Nature

Featured

• Article | 07 February 2024

  Bile salt hydrolase acyltransferase activity expands bile acid diversity

  Acyltransferase activity of the enzyme bile salt hydrolase is identified and shown to mediate microbial bile acid conjugation, diversifying the bile acid pool and expanding their role in gut physiology.

  • Douglas V. Guzior
  • , Maxwell Okros
  •  & Robert A. Quinn

• Article
  07 February 2024 | Open Access

  Bile salt hydrolase catalyses formation of amine-conjugated bile acids

  We find that bile salt hydrolase N-acyltransferase activity can form bacterial bile acid amidates that are positively correlated with the colonization of gut bacteria that assist in the regulation of the bile acid metabolic network.

  • Bipin Rimal
  • , Stephanie L. Collins
  •  & Andrew D. Patterson

• Article | 04 January 2023

  Structural basis of regulated m⁷G tRNA modification by METTL1–WDR4

  Structures of the human METTL1–WDR4 complex are revealed, providing molecular insights into substrate recognition, modification and catalytic regulation by the N⁷-methylguanosine methyltransferase complex.

  • Jiazhi Li
  • , Longfei Wang
  •  & Richard I. Gregory

• Article
  23 November 2022 | Open Access

  Structural basis of tankyrase activation by polymerization

  Structural insights into the poly-ADP-ribosyltransferase tankyrase reveal its filamentous architecture and illustrate how assembly controls catalytic and non-catalytic functions.

  • Nisha Pillay
  • , Laura Mariotti
  •  & Sebastian Guettler

• Article
  21 September 2022 | Open Access

  Structural basis for directional chitin biosynthesis

  Using cryo-electron microscopy, the directional multiple step mechanism of chitin biosynthesis is revealed.

  • Wei Chen
  • , Peng Cao
  •  & Qing Yang

• Article | 07 October 2020

  A STAT3 palmitoylation cycle promotes T_H17 differentiation and colitis

  The dynamic and reversible S-palmitoylation of the transcription factor STAT3 enhances its activation and promotes the differentiation of T_H17 cells.

  • Mingming Zhang
  • , Lixing Zhou
  •  & Hening Lin

• Article | 13 May 2020

  Structural basis for catalysis and substrate specificity of human ACAT1

  The structure of human ACAT1, which catalyses the transfer of an acyl group from acyl-coenzyme A to cholesterol to form cholesteryl ester, is resolved by cryo-electron microscopy.

  • Hongwu Qian
  • , Xin Zhao
  •  & Nieng Yan

• Article | 13 May 2020

  Structure of nevanimibe-bound tetrameric human ACAT1

  The structure of human ACAT1 in complex with the inhibitor nevanimibe is resolved by cryo-electron microscopy.

  • Tao Long
  • , Yingyuan Sun
  •  & Xiaochun Li

• Letter | 03 October 2018

  Crystal structure of a membrane-bound O-acyltransferase

  Crystal structures of DltB, a bacterial membrane-bound O-acyltransferase, are reported both alone and in complex with the d-alanyl donor protein DltC.

  • Dan Ma
  • , Zhizhi Wang
  •  & Wenqing Xu

• Letter | 06 December 2017

  KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

  The histone acetyl transferase KAT2A (also known as GCN5) can also catalyse histone succinylation, with the α-KGDH complex providing a local source of succinyl-CoA.

  • Yugang Wang
  • , Yusong R. Guo
  •  & Zhimin Lu

• Letter | 18 April 2016

  Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

  The crystal structure of the MraY enzyme from Aquifex aeolicus in complex with the naturally occurring nucleoside inhibitor muraymycin D2 (MD2) reveals that MraY undergoes a large conformational rearrangement near the active site after the binding of MD2, leading to the generation of a nucleoside-binding pocket and a peptide-binding site.

  • Ben C. Chung
  • , Ellene H. Mashalidis
  •  & Seok-Yong Lee

• Letter | 07 August 2011

  Modulation of Rab GTPase function by a protein phosphocholine transferase

  • Shaeri Mukherjee
  • , Xiaoyun Liu
  •  & Craig R. Roy