Transcription factors articles from across Nature Portfolio

Transcription factors are proteins that bind to DNA to regulate gene expression via transcription: the process by which the genetic code generates mRNAs or small RNAs. Transcription factors operate by various methods, for example, by modulating the binding of RNA polymerase or by recruiting coactivator or corepressor proteins to the DNA.

Latest Research and Reviews

Research
10 April 2023 | Open Access

A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

Here, the authors show that cell internalization of Engrailed2 not only relies on its homeodomain, but also involves a cationic region which interacts selectively with cell surface heparan sulfates.
- Sébastien Cardon
- , Yadira P. Hervis
- & Sandrine Sagan
Nature Communications 14, 1998
Research
15 February 2023 | Open Access

A NPAS4–NuA4 complex couples synaptic activity to DNA repair

A neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.
- Elizabeth A. Pollina
- , Daniel T. Gilliam
- & Michael E. Greenberg
Nature 614, 732-741
Research
18 January 2023 | Open Access

Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

Evolution-guided mutagenesis and biophysical analysis reveal that residual helical structure in the binding region of an intrinsically disordered protein regulates the lifetime of its complex by affecting its dissociation.
- Steffie Elkjær
- , Amanda D. Due
- & Karen Skriver
Communications Biology 6, 63
Research
17 January 2023 | Open Access

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65

Prime editing represents a great advance to the genome editing field but is currently limited by the editing efficiency. Here the authors look to improve the efficiency by recruiting target proteins and show that the transcription factor P65 could enhance the desired editing outcomes at different gene loci.
- Ronghao Chen
- , Yu Cao
- & Xueli Zhang
Nature Communications 14, 257
Research
08 December 2022 | Open Access

Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia
- Ferbian Milas Siswanto
- , Yumi Mitsuoka
- & Susumu Imaoka
Scientific Reports 12, 21265
Research
11 November 2022 | Open Access

Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter

This study presenting the cryo-EM structure of human SNAPc in complex with U6-1 PSE, significantly enforces our understanding of the mechanism of the SNAPc assembly, the PSE-specific recognition by SNAPc and the PIC assembly on U6 snRNA promoter.
- Jianfeng Sun
- , Xue Li
- & Wei Wang
Nature Communications 13, 6871

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News and Comment

News & Views | 27 March 2023

Measuring the impact of chromatin context on transcription factor binding affinities

We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for binding to regulatory elements across the genome. Our study shows that chromatin context and DNA accessibility are key regulators of transcription factor binding.

Nature Biotechnology, 1-2
Research Highlights | 03 January 2023

STAT5 facts
- Laurie A. Dempsey
Nature Immunology 24, 1
News & Views | 07 July 2022

A kinesin mimics DNA

Primary cilia transduce cues, including Hedgehog (Hh) signals, and possess doublet microtubules that interact with kinesin motors. The kinesin KIF7 is important for Hh signalling and binds to GLI transcription factors. Haque et al. reveal that, surprisingly, GLI proteins bind a DNA-like part of KIF7 to promote their accumulation at the ciliary tip.
- Dhivya Kumar
- & Jeremy F. Reiter
Nature Cell Biology 24, 1015-1016
Research Highlights | 17 March 2022

The root cause of shoot-borne roots

Omary et al. map shoot-borne root development at single-cell resolution in tomato to identify the origin of shoot-borne roots.
- Linda Koch
Nature Reviews Genetics 23, 264
Research Highlights | 06 January 2022

SRC2 controls the refeeding response in mice
- Olivia Tysoe
Nature Reviews Endocrinology 18, 134
News & Views | 22 December 2021

Parsing the transcription factors governing T cell immunity

Zhong et al. exploit allelic variations in mice to pinpoint the ‘heavy lifter’ transcription factor families governing the chromatin landscape of resting and activated T cells.
- Timothy M. Johanson
- & Rhys S. Allan
Nature Immunology 23, 3-4

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Transcription factors articles from across Nature Portfolio

Latest Research and Reviews

A cationic motif upstream Engrailed2 homeodomain controls cell internalization through selective interaction with heparan sulfates

A NPAS4–NuA4 complex couples synaptic activity to DNA repair

Evolutionary fine-tuning of residual helix structure in disordered proteins manifests in complex structure and lifetime

Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65

Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia

Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter

News and Comment

Measuring the impact of chromatin context on transcription factor binding affinities

STAT5 facts

A kinesin mimics DNA

The root cause of shoot-borne roots

SRC2 controls the refeeding response in mice

Parsing the transcription factors governing T cell immunity

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