The androgen receptor forms nuclear condensates associated with gene transcription. Investigating the molecular basis of condensate formation led us to discover an approach for optimizing small molecules that inhibit the receptor in a currently untreatable form of prostate cancer.
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References
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This is a summary of: Basu, S. et al. Rational optimization of a transcription factor activation domain inhibitor. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01159-5 (2023).
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Transient protein folding in condensates reveals ways to target disordered oncoproteins. Nat Struct Mol Biol 30, 1836–1837 (2023). https://doi.org/10.1038/s41594-023-01160-y
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DOI: https://doi.org/10.1038/s41594-023-01160-y
