Systemic lupus erythematosus articles within Nature

Featured

• Article | 11 May 2020

  Complement genes contribute sex-biased vulnerability in diverse disorders

  Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

  • Nolan Kamitaki
  • , Aswin Sekar
  •  & Steven A. McCarroll

• Research Highlights | 16 March 2011

  Feedback loop in lupus

• News | 10 March 2011

  First lupus drug in half a century approved

  A therapeutic antibody is the first success in a wave of experimental therapies aimed at tackling the autoimmune disease.

  • Heidi Ledford

• News | 22 June 2010

  Strange lesions after stem-cell therapy

  Unproven treatment results in mysterious masses.

  • David Cyranoski

• Letter | 17 June 2010

  TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

  Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE), but many treatment regimens cannot maintain disease control in SLE patients. Here it is shown that the stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7 and TLR9 can account for the reduced activity of glucocorticoids to inhibit the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and TLR9 signalling might prove to be effective corticosteroid-sparing drugs.

  • Cristiana Guiducci
  • , Mei Gong
  •  & Franck J. Barrat