Chemical synthesis

Chemical synthesis is the process by which one or more chemical reactions are performed with the aim of converting a reactant or starting material into a product or multiple products. Chemical synthesis is at the heart of much chemistry research as it is the basis for discovering compounds with new physical or biological properties.


Latest Research and Reviews

News and Comment

  • News & Views |

    High-temperature solutions called fluxes are widely used to synthesize solid compounds. The composition and structural properties of reaction products in a two-component flux system can now be tuned by varying the temperature and the ratio between a component of the reaction medium and a second component that serves as a ‘tuning knob’.

  • News & Views |

    The direct carbon isotope exchange reaction on α-amino acids is highly desirable, as existing labelling methods require several synthetic steps and harsh conditions. Now, an aldehyde-catalysed carboxylate exchange with isotopically labelled *CO2 has enabled the direct formation of 11C, 13C and 14C-labelled α-amino acids.

    • Karoline T. Neumann
    •  & Troels Skrydstrup
  • News & Views |

    Truly general chemical reactions work well regardless of the structural features and functional groups in the starting molecule. A new screening protocol speeds up the identification of such reactions in the field of asymmetric catalysis.

    • Manuel J. Scharf
    •  & Benjamin List
    Nature 610, 632-633
  • News & Views |

    Efforts to probe the biological functions of carbohydrates have long been limited by the lack of such molecules with well-defined structures. An automated carbohydrate synthesizer has been developed that could remedy this.

    • Hanchao Cheng
    •  & Peng George Wang
    Nature 610, 266-267