News & Views |
Featured
-
-
Article
| Open Access
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
Krastev et al. report that trapped PARP1 undergoes SUMOylation, followed by ubiquitylation, resulting in the recruitment of the p97 ATPase to remove trapped PARP1 from chromatin and prevent PARP inhibitor-induced cytotoxicity.
- Dragomir B. Krastev
- , Shudong Li
- & Christopher J. Lord
-
Article |
Heterochromatic breaks move to the nuclear periphery to continue recombinational repair
Chiolo and colleagues find that, in a SUMOylation-dependent manner, heterochromatic double-strand breaks move to the nuclear periphery where Rad51 is recruited to continue repair.
- Taehyun Ryu
- , Brett Spatola
- & Irene Chiolo
-
Letter |
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction
The segregase Cdc48 (also called p97 or VCP) extracts ubiquitylated proteins from their environment. Jentsch and colleagues demonstrate that Cdc48 binds SUMOylated Rad52, and removes Rad52 and the recombinase Rad51 from DNA to restrict spontaneous recombination.
- Steven Bergink
- , Tim Ammon
- & Stefan Jentsch
-
-
Letter |
The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast
Budding yeast telomeres are anchored to the nuclear envelope. Siz2-mediated SUMOylation of Yku70/80 and Sir4, both known to mediate telomere anchoring, is found to promote telomere localisation at the nuclear envelope and restrain their elongation.
- Helder C. Ferreira
- , Brian Luke
- & Susan M. Gasser
-
Letter |
SUMOylation of the GTPase Rac1 is required for optimal cell migration
The SUMO E3 ligase PIAS3 is shown to promote Rac1 SUMOylation. This modification stimulates Rac1 activity and regulates its ability to drive lamellipodium formation.
- Sonia Castillo-Lluva
- , Michael H. Tatham
- & Angeliki Malliri
Unsprung traps keep PARP inhibitors effective