Structure determination articles within Nature Biotechnology

Featured

• Article | 23 February 2024

  All-atom RNA structure determination from cryo-EM maps

  RNA structures are built from cryogenic electron microscopy maps using deep learning and backbone tracing.

  • Tao Li
  • , Jiahua He
  •  & Sheng-You Huang

• News & Views | 08 April 2014

  Cas9 in close-up

  Structural and biochemical studies elucidate DNA targeting by the Cas9 endonuclease.

  • Erin L Garside
  •  & Andrew M MacMillan

• Article | 26 January 2014

  Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

  Bispecifics by orthogonal interfaces To improve correct antibody heavy-light chain pairing during bispecific antibody assembly, Lewis et al. design antibody heavy and light chains with orthogonal interfaces.

  • Steven M Lewis
  • , Xiufeng Wu
  •  & Stephen J Demarest

• Letter | 21 October 2012

  Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

  Martell et al. engineer APEX, a protein tag for electron microscopy that does not require light activation, enabling the imaging of subcellular protein localization in large or thick sections.

  • Jeffrey D Martell
  • , Thomas J Deerinck
  •  & Alice Y Ting

• Perspective | 08 April 2011

  Overcoming barriers to membrane protein structure determination

  • Roslyn M Bill
  • , Peter J F Henderson
  •  & Horst Vogel