Raman spectroscopy articles within Nature Communications

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  • Article
    | Open Access

    Authors present a centimeter-scale miniaturized Raman spectrometer using cheap nonstabilized laser diodes, densely packed optics, and non-cooled small sensors while the performance is comparable with expensive bulky research-grade Raman systems.

    • Oleksii Ilchenko
    • , Yurii Pilhun
    •  & Anja Boisen

  • Article
    | Open Access

    Bioimaging with photocontrol and multiplexing capability is vital for studying cellular interactions and dynamics, but multiplexed stimulated Raman scattering (SRS) imaging with reversible photocontrol is elusive. Here, the authors report SRS microscopy with Carbow-switch enabling multiplexed SRS imaging and tracking in live cells with reversible photocontrol and high spatiotemporal selectivity.

    • Yueli Yang
    • , Xueyang Bai
    •  & Fanghao Hu

  • Article
    | Open Access

    The nature of the molecule-metal interface is crucial for many technological applications. Here, the authors show that the photostability of the material can be sensitive to room light when coated with a single molecular layer, with implications for devices and processes.

    • Chenyang Guo
    • , Philip Benzie
    •  & Jeremy J. Baumberg

  • Article
    | Open Access

    Hyperbolic phonon polaritons (HPhPs) in anisotropic van der Waals materials hold promise for nanophotonic applications, but their far-field characterization remains challenging. Here, the authors demonstrate the application of Raman spectroscopy in a backscattering configuration to determine the dispersion of HPhPs in thin GaSe crystals.

    • Alaric Bergeron
    • , Clément Gradziel
    •  & Sébastien Francoeur

  • Article
    | Open Access

    Coherent Stokes Raman scattering (CSRS) has never been explored previously for chemical imaging due to a strong fluorescence background. Here, the authors demonstrate the first fluorescence-free CSRS laser scanning microscope and predict CSRS’ unique backscattering properties.

    • Sandro Heuke
    •  & Hervé Rigneault

  • Article
    | Open Access

    Spontaneous Raman scattering is classically understood as an incoherent process. Here, the authors demonstrate that macroscopic quantum coherence among billions of vibrating molecules in a liquid is generated when single photon detection and single spatio-temporal mode excitation are implemented.

    • Valeria Vento
    • , Santiago Tarrago Velez
    •  & Christophe Galland

  • Article
    | Open Access

    Two-dimensional charge density waves in layered semiconductors may exhibit chirality. Here, the authors utilize thermal annealing to reversibly switch the in-plane chirality of charge density waves in 1T-TaS2 and demonstrate a vertical chirality-locking effect between the van der Waals-stacked layers.

    • Yan Zhao
    • , Zhengwei Nie
    •  & Jin Zhang

  • Article
    | Open Access

    Direct spectroscopic probes of the impact of structure on dynamical processes in liquids remain scarce. Here, the authors use molecular dynamics simulations to show that the correlation between vibrational coupling and the local tetrahedral structure of liquid water can be studied via hybrid terahertz- and infrared-Raman spectroscopy.

    • Tomislav Begušić
    •  & Geoffrey A. Blake

  • Article
    | Open Access

    Physical or chemical reactions driven by light absorption are ruled by excited-state multidimensional energy surfaces displaced with respect to the ground state. Here the authors introduce a nonlinear Raman experiment to access an elusive aspect of the excited-state displacements: their sensed directions relative to the ground-state.

    • Giovanni Batignani
    • , Emanuele Mai
    •  & Tullio Scopigno

  • Article
    | Open Access

    Tip-enhanced vibrational spectroscopy at room temperature is complicated by molecular conformational dynamics, photobleaching, contaminations, and chemical reactions in air. This study demonstrates that a sub-nm protective layer of Al2O3 provides robust conditions for probing single-molecule conformations.

    • Mingu Kang
    • , Hyunwoo Kim
    •  & Kyoung-Duck Park

  • Article
    | Open Access

    MnBi2Te4, referred to as MBT, is a van der Waals material combining topological electron bands with magnetic order. Here, Lujan et al study collective spin excitations in MBT, and show that magnetic fluctuations increase as samples reduce in thickness, implying less robust magnetic order.

    • David Lujan
    • , Jeongheon Choe
    •  & Xiaoqin Li

  • Article
    | Open Access

    Here, the authors demonstrate intra-cavity excitation and time-domain sampling of coherent optical phonons inside an active laser oscillator. They discover that Terahertz crystal vibrations link successive ultrashort solitons which offers an approach to highspeed Raman spectroscopy inside laser cavities.

    • Alexandra Völkel
    • , Luca Nimmesgern
    •  & Georg Herink

  • Article
    | Open Access

    Here, the authors report the use of ultrahigh vacuum tip-enhanced Raman spectroscopy to characterize the oxidation processes of monolayer borophene with atomic-scale resolution and single-bond sensitivity, demonstrating the potential of the technique for probing the local chemistry of surface adsorbates on low-dimensional materials.

    • Linfei Li
    • , Jeremy F. Schultz
    •  & Nan Jiang

  • Article
    | Open Access

    Quantum interference among elementary Raman processes has only been observed in few materials under specific excitation configurations. Here, the authors show that quantum interference can lead to significant chiral Raman response in a monolayer material of transitional metal dichalcogenide with triclinic symmetry.

    • Shishu Zhang
    • , Jianqi Huang
    •  & Jin Zhang

  • Article
    | Open Access

    The authors demonstrate a sensing approach for effectively monitoring organic micropollutants in water. They first use mesoporous nanosponge and magnetic nanoparticles for fast enrichment of micropollutants, and demonstrate SERS-based sensing with 2-3 orders of magnitude improvement in detection limits.

    • Lingling Zhang
    • , Yu Guo
    •  & Jixiang Fang

  • Article
    | Open Access

    Tracking single molecule movements is a challenging task, but highly desired for applications and fundamental studies. Here the authors reconstruct the sub-angstrom relative movements of a molecule interacting with a metal adatom, by measuring its vibrational spectrum in a self-assembled monolayer, continuously modified by the adatom in a nanoparticle-on-mirror construct.

    • Jack Griffiths
    • , Tamás Földes
    •  & Jeremy J. Baumberg

  • Article
    | Open Access

    Existing methods for non-invasively monitoring water flow in plants have limited spatial/temporal resolution. Here, the authors report that Raman microspectroscopy, complemented by hydrodynamic modelling, can monitor hydrodynamics within living root tissues at cell- and sub-second-scale resolutions.

    • Flavius C. Pascut
    • , Valentin Couvreur
    •  & Kevin F. Webb

  • Article
    | Open Access

    The authors develop a method to build Manhattan Raman Scattering (MARS) probes based on different core atoms, conjugation ring numbers, and stable isotope substitutions. A quantitative model predicts vibrational frequencies of MARS dyes from structures, which are used in supermultiplexed vibrational imaging.

    • Yupeng Miao
    • , Naixin Qian
    •  & Wei Min

  • Article
    | Open Access

    Super-resolution microscopy is often limited by photobleaching or uneven distribution of fluorophores. The authors present a label-free superresolution method termed VISTA, combining sample-expansion and vibrational imaging, with resolution down to 78 nm in protein-rich biological structures in cells and tissues.

    • Chenxi Qian
    • , Kun Miao
    •  & Lu Wei

  • Article
    | Open Access

    Tip-enhanced nano-spectroscopy suffers from inconsistent signal and difficulty in polarization-resolved measurement. Here, the authors present adaptive tip-enhanced nano-spectroscopy, which enables the additional signal enhancement and near-field polarization control via dynamic wavefront shaping.

    • Dong Yun Lee
    • , Chulho Park
    •  & Kyoung-Duck Park

  • Article
    | Open Access

    Currently relatively few functional probes for Raman-based live-cell profiling exist. Here the authors build on their previous ultra-bright Raman dots to devise a 14-plexed Raman probe panel to quantify cell surface proteins, endocytosis activities and metabolic dynamics of single live cells.

    • Chen Chen
    • , Zhilun Zhao
    •  & Wei Min

  • Article
    | Open Access

    Probes with reversible fluorescence are useful in super-resolution microscopy, but lack sufficient chemical specificity. Here, the authors engineer alkyne tagged diarylethene to realize photo-switchable stimulated Raman scattering probes with high chemical resolution, for applications in living cells.

    • Jianpeng Ao
    • , Xiaofeng Fang
    •  & Minbiao Ji

  • Article
    | Open Access

    Raman optical activity (ROA) is useful for studying conformational structure and behavior of chiral molecules, but is limited by the weak signals. Here, the authors demonstrate 100x signal enhancement via an all-dielectric approach, using a silicon nanodisk array and exploiting its dark mode.

    • Ting-Hui Xiao
    • , Zhenzhou Cheng
    •  & Keisuke Goda

  • Article
    | Open Access

    In situ vibrational spectroscopy affords a powerful tool for probing elementary chemical processes on catalytic surfaces. Using surface enhanced Raman scattering, authors identify an array of multicarbon species formed on a Ag nanoparticle catalyst in plasmon-driven reduction of CO2 in water.

    • Dinumol Devasia
    • , Andrew J. Wilson
    •  & Prashant K. Jain

  • Article
    | Open Access

    Raman-based imaging of biomarkers is often challenging due to low sensitivity. Here, the authors use a swelling-diffusion approach to develop a series of Raman probes that are both ultra-bright and compact in size, and demonstrate multiplexed imaging of specific protein targets in cells and tissue slices.

    • Zhilun Zhao
    • , Chen Chen
    •  & Wei Min

  • Article
    | Open Access

    It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features.

    • Xin Dai
    • , Wenhao Fu
    •  & Jinqing Huang

  • Article
    | Open Access

    There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.

    • Junrong Li
    • , Alain Wuethrich
    •  & Matt Trau

  • Article
    | Open Access

    Identification of neurotransmitters remains challenging for surface enhanced Raman spectroscopy (SERS) due to presence of noise. Here, the authors present spread spectrum SERS, which by encoding excited light and decoding SERS signals enables detection of unlabelled neurotransmitters at attomolar concentrations.

    • Wonkyoung Lee
    • , Byoung-Hoon Kang
    •  & Ki-Hun Jeong

  • Article
    | Open Access

    Raman spectroscopic imaging (RSI) can provide information on the chemical composition of a sample, but application to living organisms has lacked sufficient spatial resolution and signal strength. Here the authors apply confocal RSI to whole-mount zebrafish embryos to distinguish different infectious bacteria and to living zebrafish embryos to monitor the wound healing process.

    • Håkon Høgset
    • , Conor C. Horgan
    •  & Molly M. Stevens

  • Article
    | Open Access

    SERS can be unreliable for biomedical use. The authors demonstrate a metal-free nanostructure composed of porous carbon nanowires in an array as a SERS substrate. It offers 106 signal enhancement due to strong broadband charge-transfer resonance and substrate-to-substrate, spot-to-spot and time-to-time consistency in the SERS spectrum.

    • Nan Chen
    • , Ting-Hui Xiao
    •  & Keisuke Goda

  • Article
    | Open Access

    Single-cell metabolomics can offer deep insights into the metabolic reprogramming that accompanies disease states. Here, the authors use Raman spectro-microscopy for non-invasive metabolite analysis and identification of druggable metabolic susceptibilities in single live melanoma cells.

    • Jiajun Du
    • , Yapeng Su
    •  & Lu Wei

  • Article
    | Open Access

    Most current cell sorting methods are based on fluorescence detection with no imaging capability. Here the authors generate and use Raman image-activated cell sorting with a throughput of around 100 events per second, providing molecular images with no need for labeling.

    • Nao Nitta
    • , Takanori Iino
    •  & Keisuke Goda

  • Article
    | Open Access

    The authors develop a first-principles workflow for calculating Raman spectra of 733 monolayers from the computational 2D materials database. After benchmarking results against experimental data for 15 monolayers, an automatic procedure for identifying a material from its Raman spectrum is proposed.

    • Alireza Taghizadeh
    • , Ulrik Leffers
    •  & Kristian S. Thygesen

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