Prefrontal cortex articles from across Nature Portfolio

The prefrontal cortex is a cortical area located in the anterior frontal lobe, including several subdivisions (e.g. ventromedial, dorsolateral, orbitofrontal cortices). The prefrontal cortex functions in cognitive control (e.g. planning, attention, problem-solving, error-monitoring, decision-making, social cognition, and working memory).

Latest Research and Reviews

Research
04 April 2023 | Open Access

Increased cortical structural covariance correlates with anhedonia in schizophrenia
- Lingfang Yu
- , Zenan Wu
- & Chen Zhang
Schizophrenia 9, 19
Research | 22 March 2023

Altered brain activity in unipolar depression unveiled using connectomics

Cash et al. examined whether coordinates derived from neuroimaging studies might delineate a dysfunctional brain network in unipolar depression rather than isolated neuroanatomical foci. The authors found highly robust distributed brain networks that closely recapitulate clinically meaningful models of depression circuitry.
- Robin F. H. Cash
- , Veronika I. Müller
- & Andrew Zalesky
Nature Mental Health 1, 174-185
Research
21 February 2023 | Open Access

High and low worriers do not differ in unstimulated resting-state brain connectivity
- Fanny Weber-Goericke
- & Markus Muehlhan
Scientific Reports 13, 3052
Research
10 February 2023 | Open Access

Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information
- Laura A. Agee
- , Emily N. Hilz
- & Marie-H. Monfils
Scientific Reports 13, 2429
Research
20 January 2023 | Open Access

Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder
- Giovana C. Macedo
- , Max Kreifeldt
- & Candice Contet
Neuropsychopharmacology 48, 821-830
Research
10 December 2022 | Open Access

Offline rTMS inhibition of the right dorsolateral prefrontal cortex impairs reappraisal efficacy
- Miroslaw Wyczesany
- , Agnieszka K. Adamczyk
- & Tomasz S. Ligeza
Scientific Reports 12, 21394

All Research & Reviews

News and Comment

Editorial | 07 April 2020

I am not biased. It is everyone else’s problem
- Tim R Watkins
- & Lisa A Harvey
Spinal Cord 58, 389-390
Research Highlights | 02 April 2020

Hot and bothered
- Natasha Bray
Nature Reviews Neuroscience 21, 245
Research Highlights | 29 January 2020

A stand-out loop

One of two anatomically and functionally characterized subpopulations of neurons in the mouse paraventricular thalamus forms a thalamo-corticothalamic loop with the infralimbic cortex that regulates arousal.
- Natasha Bray
Nature Reviews Neuroscience 21, 120
Research Highlights | 24 April 2019

Lasting restoration

Certain lasting antidepressant effects of ketamine in a mouse model of depression depend on the restoration of dendritic spines in the prefrontal cortex.
- Natasha Bray
Nature Reviews Neuroscience 20, 315
Research Highlights | 27 November 2018

Boosting a bad signal

Dopamine released in the rodent prefrontal cortex increases the signal-to-noise ratio of responses to aversive stimuli that are transmitted to the periaqueductal grey.
- Natasha Bray
Nature Reviews Neuroscience 20, 4
Research Highlights | 28 August 2018

Concentrating on the claustrum

Two studies show that the claustrum delivers inhibition to different parts of the cortex — the prefrontal cortex and auditory cortex.
- Natasha Bray
Nature Reviews Neuroscience 19, 580-581

All News & Comment

Prefrontal cortex articles from across Nature Portfolio

Latest Research and Reviews

Increased cortical structural covariance correlates with anhedonia in schizophrenia

Altered brain activity in unipolar depression unveiled using connectomics

High and low worriers do not differ in unstimulated resting-state brain connectivity

Patterns of Arc mRNA expression in the rat brain following dual recall of fear- and reward-based socially acquired information

Chronic MAP4343 reverses escalated alcohol drinking in a mouse model of alcohol use disorder

Offline rTMS inhibition of the right dorsolateral prefrontal cortex impairs reappraisal efficacy

News and Comment

I am not biased. It is everyone else’s problem

Hot and bothered

A stand-out loop

Lasting restoration

Boosting a bad signal

Concentrating on the claustrum

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