Polycystic ovary syndrome articles within Nature Communications

Featured

• Article
  12 January 2016 | Open Access

  Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion

  Anti-Müllerian hormone (AMH) plays a role in sexual differentiation and gonadal function, but extra-gonadal effects of AMH are not known. Here Cimino et al. show that AMH activates a subset of gonadotrophin-releasing hormone (GnRH)-releasing neurons, contributing to luteinizing hormone secretion from the pituitary gland.

  • Irene Cimino
  • , Filippo Casoni
  •  & Paolo Giacobini

• Article
  29 September 2015 | Open Access

  Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome

  This paper describes the largest genome-wide association study to date on polycystic ovary syndrome (PCOS), a common reproductive disorder in women. Six genetic loci—including known targets of cancer chemotherapy—were identified, and the authors infer causal and balancing selection mechanisms involved in PCOS risk and susceptibility.

  • Felix R. Day
  • , David A. Hinds
  •  & John R. B. Perry

• Article
  18 August 2015 | Open Access

  Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

  Polycystic Ovary Sydrome is a highly heritable, complex reproductive disorder with unknown underlying genetic factors. Here Hayes and Urbanek et al. identify three loci in European women strongly associated with neuroendocrine changes and disease susceptibility.

  • M. Geoffrey Hayes
  • , Margrit Urbanek
  •  & Andrea Dunaif