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Open Access
Featured
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Article
| Open AccessThe requirement of the mitochondrial protein NDUFS8 for angiogenesis
- Qian-wei Xiong
- , Kun Jiang
- & Xu Cao
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Article
| Open AccessOrthogonal analysis of mitochondrial function in Parkinson’s disease patients
- Sander Barnhoorn
- , Chiara Milanese
- & Pier G. Mastroberardino
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Article
| Open AccessHNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy
- Yuxing Hou
- , Pengxi Shi
- & Jiantao Li
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Article
| Open AccessMechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop
- Jiahao He
- , Xinwei Cheng
- & Qingfeng Li
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Article
| Open AccessDeath receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis
- Jianbo Liu
- , Kaixuan Liu
- & Bing Xue
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Article
| Open AccessAtypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice
- Atsuhiko Ichimura
- , Yuu Miyazaki
- & Hiroshi Takeshima
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Article
| Open AccessInhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis
- Shu Yang
- , Han Wu
- & Zhen Liang
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Article
| Open AccessClass IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity
- Sheree D. Martin
- , Timothy Connor
- & Sean L. McGee
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Article
| Open AccessInhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis
- Yuting Zhang
- , Weijuan Xin
- & Jiajun Fan
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Article
| Open AccessDUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK
- Lang Shi
- , Hongchu Zha
- & Jiefu Zhu
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Article
| Open AccessGRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability
- Doudou Liu
- , Chenzhong Xu
- & Jun Chen
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Article
| Open AccessSohlh2 promotes pulmonary fibrosis via repression of p62/Keap1/Nrf2 mediated anti-oxidative signaling pathway
- Lanlan Liu
- , Xiaoli Zhang
- & Jing Hao
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Article
| Open AccessInherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein
- Norio Motohashi
- , Katsura Minegishi
- & Yoshitsugu Aoki
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Article
| Open AccessPACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
- Jinfei Yang
- , Li Li
- & Lin Sun
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Article
| Open AccessMajor vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts
- Ruobing Wang
- , Yan Yang
- & Lichan Yuan
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Article
| Open AccessDlk2 interacts with Syap1 to activate Akt signaling pathway during osteoclast formation
- Xinwei Chen
- , Xuzhuo Chen
- & Shanyong Zhang
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Article
| Open AccessPlk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis
- Yang Du
- , Yaqiong Shang
- & Yue Zhang
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Article
| Open AccessTargeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease
- Madlen Kunke
- , Hannah Knöfler
- & Franziska Theilig
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Article
| Open AccessSmooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6
- Qiming Deng
- , Hongxuan Li
- & Wencheng Zhang
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Article
| Open AccessNeuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
- Kang Zheng
- , Fengjie Hao
- & Francisco Javier Cubero
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Review Article
| Open AccessResearch progress on endoplasmic reticulum homeostasis in kidney diseases
- Dan Wu
- , Li-Feng Huang
- & Chen Yang
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Article
| Open AccessA Dhdds K42E knock-in RP59 mouse model shows inner retina pathology and defective synaptic transmission
- Mai N. Nguyen
- , Dibyendu Chakraborty
- & Steven J. Pittler
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Article
| Open AccessThe EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
- Yamato Fukui
- , Yasushi Hirota
- & Yutaka Osuga
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Article
| Open AccessUpregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1
- Dan-Hong Xu
- , Jian-Kui Du
- & Yu-Jian Liu
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Article
| Open AccessMitochondria-derived H2O2 triggers liver regeneration via FoxO3a signaling pathway after partial hepatectomy in mice
- Hua Bai
- , Cong-Wen Fang
- & Xu-Jun Qin
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Article
| Open AccessGPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway
- Guoqiang Fan
- , Yanfei Li
- & Xiaojing Yang
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Article
| Open AccessHIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
- Jialin Li
- , Qisheng Lin
- & Zhaohui Ni
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Article
| Open AccessThe UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
- Lifen Xu
- , Yuxia Zhou
- & Bing Guo
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Article
| Open AccessMelatonin-mediated FKBP4 downregulation protects against stress-induced neuronal mitochondria dysfunctions by blocking nuclear translocation of GR
- Min Jeong Kim
- , Gee Euhn Choi
- & Ho Jae Han
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Article
| Open AccessRho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis
- Huiruo Liu
- , Hang Yin
- & Chuanbao Li
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Article
| Open AccessSARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters
- Gemma Bogard
- , Johanna Barthelemy
- & Isabelle Wolowczuk
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Article
| Open AccessCaspase-9 driven murine model of selective cell apoptosis and efferocytosis
- Lena Batoon
- , Amy J. Koh
- & Hernan Roca
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Article
| Open AccessFUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM
- Yaguang Bi
- , Haixia Xu
- & Yingmei Zhang
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Article
| Open AccessSphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
- Feifei Yuan
- , Xiaoqiong Hao
- & Meijia Zhang
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Article
| Open AccessTargeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis
- Xiaochun Yin
- , Jin Peng
- & Feng Zhang
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Article
| Open AccessMYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
- Xiaodong Zou
- , Hongsheng Ouyang
- & Xiaochun Tang
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Article
| Open AccessMutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance
- Wan-Hui Guo
- , Qi Guo
- & Mi Yang
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Article
| Open AccessActivation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites
- Agnieszka A. Kusiak
- , Monika A. Jakubowska
- & Pawel E. Ferdek
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Article
| Open AccessGermline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation
- Fu-Rong Bai
- , Qi-Qian Wu
- & Jing-Wen Wu
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Article
| Open AccessANGPTL8 is a negative regulator in pathological cardiac hypertrophy
- Lin Hu
- , Jiarui Wei
- & Qiufang Zhang
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Article
| Open AccessA potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss
- Barbara Peixoto Pinheiro
- , Marcus Müller
- & Hubert Löwenheim
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Review Article
| Open AccessCell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases
- Yiran E. Li
- , James R. Sowers
- & Jun Ren
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Article
| Open AccessGlutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway
- Jitai Zhang
- , Juan Bai
- & Ming Li
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Article
| Open AccessYAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity
- Gwan-Jun Lee
- , Youn Ju Kim
- & Hyunsung Park
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Article
| Open AccessAutophagy guards tendon homeostasis
- Costanza Montagna
- , Rene B. Svensson
- & Michael Kjær
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Article
| Open AccessLon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca2+ release in cancer cells
- Vidhya Tangeda
- , Yu Kang Lo
- & Jang-Yang Chang
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Article
| Open AccessDichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis
- Taylor Gillmore
- , Abby Farrell
- & Isabella Caniggia
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Article
| Open AccessEnhanced glycolysis in granulosa cells promotes the activation of primordial follicles through mTOR signaling
- Xiaodan Zhang
- , Wenbo Zhang
- & Meijia Zhang
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Article
| Open AccessCardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis
- Jun Lin
- , Qinfeng Li
- & Guosheng Fu