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Article
| Open AccessInhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis
- Yuting Zhang
- , Weijuan Xin
- & Jiajun Fan
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Article
| Open AccessSmooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6
- Qiming Deng
- , Hongxuan Li
- & Wencheng Zhang
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Article
| Open AccessRho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis
- Huiruo Liu
- , Hang Yin
- & Chuanbao Li
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Article
| Open AccessFUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM
- Yaguang Bi
- , Haixia Xu
- & Yingmei Zhang
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Article
| Open AccessMYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
- Xiaodong Zou
- , Hongsheng Ouyang
- & Xiaochun Tang
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Review Article
| Open AccessCell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases
- Yiran E. Li
- , James R. Sowers
- & Jun Ren
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Article
| Open AccessCardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis
- Jun Lin
- , Qinfeng Li
- & Guosheng Fu
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Article
| Open AccessMisoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3
- Matthew D. Martens
- , Nivedita Seshadri
- & Joseph W. Gordon
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Review Article
| Open Access“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
- Yvonne Sleiman
- , Alain Lacampagne
- & Albano C. Meli
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Article
| Open AccessCardiac-specific CGI-58 deficiency activates the ER stress pathway to promote heart failure in mice
- Xin Xie
- , Yi-Fan Tie
- & Ying Liu
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Article
| Open AccessIGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA
- Sangmi Ock
- , Woojin Ham
- & Jaetaek Kim
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Article
| Open AccessZFP36L2 regulates myocardial ischemia/reperfusion injury and attenuates mitochondrial fusion and fission by LncRNA PVT1
- Fang Wu
- , Weifeng Huang
- & Yingchuan Li
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Article
| Open AccessThe adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells
- Yong Sook Kim
- , Hyang Hee Cho
- & Youngkeun Ahn
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Article
| Open AccessAcute glucose influx-induced mitochondrial hyperpolarization inactivates myosin phosphatase as a novel mechanism of vascular smooth muscle contraction
- Jie Xu
- , Hongyan Yang
- & Feng Gao
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Article
| Open AccessVagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling
- Bin Luo
- , Yan Wu
- & Jun-ming Tang
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Article
| Open AccessPhosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion
- Stephen Hurst
- , Fabrice Gonnot
- & Shey-Shing Sheu
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Article
| Open AccessInhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing
- Olof Gidlöf
- , Kerstin Bader
- & David Erlinge
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Article
| Open AccessAlpha-lipoic acid protects against pressure overload-induced heart failure via ALDH2-dependent Nrf1-FUNDC1 signaling
- Wenjia Li
- , Lei Yin
- & Junbo Ge
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Article
| Open AccessHigh glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression
- Jing Wang
- , Xuefang Shen
- & Changhong Miao
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Article
| Open AccessA necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression
- Jialin Dai
- , Chonghe Zhang
- & Junhao Hu
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Article
| Open Accessα-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux
Schematic diagram of the mechanisms whereby α-linolenic acid protects against endothelial dysfunction and hypertension.
- Guohua Li
- , Xinpei Wang
- & Jia Li
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Article
| Open AccessTNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways
- Lei Gao
- , Li-you Wang
- & Dong-ying Zhang
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Article
| Open AccessHypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility
- Yue-Feng Liu
- , Juan-Juan Zhu
- & Jing Zhou
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Article
| Open AccessThe long non-coding RNA TUG1-miR-9a-5p axis contributes to ischemic injuries by promoting cardiomyocyte apoptosis via targeting KLF5
- Di Yang
- , Jie Yu
- & Zhi-Min Du
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Article
| Open AccessKindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy
- Lihua Qi
- , Xiaochun Chi
- & Hongquan Zhang
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Article
| Open AccessActivation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet
- Yun-Ting Wang
- , Xiang Li
- & Yang Zhang
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Article
| Open AccessTranslationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism
- Wenqian Cai
- , Takayuki Fujita
- & Yoshihiro Ishikawa
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Article
| Open AccessC1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress
- Bing Zhang
- , Ping Zhang
- & Wei Yi
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Article
| Open AccessTLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis
- Fang-Yuan Liu
- , Di Fan
- & Qi-Zhu Tang
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Article
| Open AccessExosomes derived from M1 macrophages aggravate neointimal hyperplasia following carotid artery injuries in mice through miR-222/CDKN1B/CDKN1C pathway
- Zeng Wang
- , Hong Zhu
- & Junbo Ge
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Article
| Open AccessOridonin protects against cardiac hypertrophy by promoting P21-related autophagy
- Man Xu
- , Chun-xia Wan
- & Qi-Zhu Tang
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Article
| Open AccessAltered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype
- Hripsimé Nahapetyan
- , Manon Moulis
- & Cécile Vindis
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Original Article
| Open AccessPlasminogen kringle 5 suppresses gastric cancer via regulating HIF-1α and GRP78
- Shuhuan Fang
- , Honghai Hong
- & Xia Yang
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Original Article
| Open AccessDoxorubicin upregulates CXCR4 via miR-200c/ZEB1-dependent mechanism in human cardiac mesenchymal progenitor cells
- Sara Beji
- , Giuseppina Milano
- & Elisa Gambini
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Original Article
| Open Accessp53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure
- Chih-Yang Huang
- , Pei-Ying Pai
- & Chih-Yang Huang
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Original Article
| Open AccessExogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy
- Jichao Wu
- , Zhiliang Tian
- & Weihua Zhang
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Original Article
| Open AccessLoss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia
- Angelika Beneke
- , Annemarie Guentsch
- & Dörthe M Katschinski
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Original Article
| Open AccessFGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway
- Jinpeng Li
- , Sen Shi
- & Daisuke Koya
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Original Article
| Open AccessAutophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats
- Lixuan Zhan
- , Siyuan Chen
- & En Xu
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Original Article
| Open AccesslncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy
- Xiang Zhou
- , Wei Zhang
- & Xiangqing Kong
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Original Article
| Open AccessMICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70
- Qiang Xue
- , Haifeng Pei
- & Ling Tao
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Original Article
| Open AccessDickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress
- Mingxue Di
- , Lin Wang
- & Mei Zhang
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Original Article
| Open AccessSphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain
- Dan-Dan Song
- , Tong-Tong Zhang
- & Rui Sheng
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Original Article
| Open AccessReduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat
- Speranza Rubattu
- , Rosita Stanzione
- & Massimo Volpe
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Original Article
| Open AccessEssential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart
- Lauren J Maskell
- , Kashif Qamar
- & Vishwanie S Budhram-Mahadeo
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Original Article
| Open AccessThe role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke
- Elisabetta Bonfanti
- , Paolo Gelosa
- & Maria P Abbracchio
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Original Article
| Open AccessUpconversion nanoparticle-mediated photodynamic therapy induces autophagy and cholesterol efflux of macrophage-derived foam cells via ROS generation
- Xiaobo B Han
- , Hongxia X Li
- & Liming M Yang
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Original Article
| Open AccessCystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units
- Jing Zou
- , Zhaoyu Chen
- & Qing Wang
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Original Article
| Open AccessProtein disulfide isomerase-mediated apoptosis and proliferation of vascular smooth muscle cells induced by mechanical stress and advanced glycosylation end products result in diabetic mouse vein graft atherosclerosis
- Suning Ping
- , Shuying Liu
- & Chaohong Li