Parasite host response

  • Article | | open

    In the study, the authors identify a protein excreted by the parasite Trichuris muris, p43, which can modulate IL-13 function, a key cytokine involved in host protection. These data suggest that p43 may be a novel therapeutic target for both whipworm infections and IL13 mediated pathologies.

    • Allison J. Bancroft
    • , Colin W. Levy
    • , Thomas A. Jowitt
    • , Kelly S. Hayes
    • , Seona Thompson
    • , Edward A. Mckenzie
    • , Matthew D. Ball
    • , Eamon Dubaissi
    • , Aidan P. France
    • , Bruno Bellina
    • , Catherine Sharpe
    • , Aleksandr Mironov
    • , Sheila L. Brown
    • , Peter C. Cook
    • , Andrew S. MacDonald
    • , David J. Thornton
    •  & Richard K. Grencis
  • Article | | open

    Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T. gondii strains.

    • Mateo Murillo-León
    • , Urs B. Müller
    • , Ines Zimmermann
    • , Shishir Singh
    • , Pia Widdershooven
    • , Cláudia Campos
    • , Catalina Alvarez
    • , Stephanie Könen-Waisman
    • , Nahleen Lukes
    • , Zsolt Ruzsics
    • , Jonathan C. Howard
    • , Martin Schwemmle
    •  & Tobias Steinfeldt
  • Article | | open

    Host-parasite interactions during the exoerythrocytic stage of Plasmodium infection remains poorly understood. Using dual RNA-Seq, the authors show that human mucosal immunity protein mucin-13 is upregulated during Plasmodium hepatic-stage infection and marks infected cells independent of tested Plasmodium species.

    • Gregory M. LaMonte
    • , Pamela Orjuela-Sanchez
    • , Jaeson Calla
    • , Lawrence T. Wang
    • , Shangzhong Li
    • , Justine Swann
    • , Annie N. Cowell
    • , Bing Yu Zou
    • , Alyaa M. Abdel-Haleem Mohamed
    • , Zaira Hellen Villa Galarce
    • , Marta Moreno
    • , Carlos Tong Rios
    • , Joseph M. Vinetz
    • , Nathan Lewis
    •  & Elizabeth A. Winzeler
  • Article | | open

    Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for oral administration.

    • Marianela C. Serradell
    • , Lucía L. Rupil
    • , Román A. Martino
    • , César G. Prucca
    • , Pedro G. Carranza
    • , Alicia Saura
    • , Elmer A. Fernández
    • , Pablo R. Gargantini
    • , Albano H. Tenaglia
    • , Juan P. Petiti
    • , Renata R. Tonelli
    • , Nicolás Reinoso-Vizcaino
    • , José Echenique
    • , Luciana Berod
    • , Eliane Piaggio
    • , Bertrand Bellier
    • , Tim Sparwasser
    • , David Klatzmann
    •  & Hugo D. Luján
  • Article | | open

    The glycome of parasites can have immunomodulatory properties or help to avoid immune surveillance, but details are unknown. Here, Martini et al. characterize the N-glycome of the canine heartworm, reveal an unprecedented complexity, particularly in anionic N-glycans, and determine recognition by components of the immune system.

    • Francesca Martini
    • , Barbara Eckmair
    • , Saša Štefanić
    • , Chunsheng Jin
    • , Monika Garg
    • , Shi Yan
    • , Carmen Jiménez-Castells
    • , Alba Hykollari
    • , Christine Neupert
    • , Luigi Venco
    • , Daniel Varón Silva
    • , Iain B. H. Wilson
    •  & Katharina Paschinger
  • Article | | open

    The inflammasome is an essential component of inflammatory processes and the host response to infection. Here the authors show that inflammasome activation modulates MyD88-IRF7 type I IFN signalling and anti-malaria immunity.

    • Xiao Yu
    • , Yang Du
    • , Chunmei Cai
    • , Baowei Cai
    • , Motao Zhu
    • , Changsheng Xing
    • , Peng Tan
    • , Meng Lin
    • , Jian Wu
    • , Jian Li
    • , Mingjun Wang
    • , Helen Y. Wang
    • , Xin-zhuan Su
    •  & Rong-Fu Wang
  • Article | | open

    Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia.

    • Leen Vandermosten
    • , Thao-Thy Pham
    • , Sofie Knoops
    • , Charlotte De Geest
    • , Natacha Lays
    • , Kristof Van der Molen
    • , Christopher J. Kenyon
    • , Manu Verma
    • , Karen E. Chapman
    • , Frans Schuit
    • , Karolien De Bosscher
    • , Ghislain Opdenakker
    •  & Philippe E. Van den Steen
  • Article | | open

    Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.

    • Maria C. Silva
    • , Marcela Davoli-Ferreira
    • , Tiago S. Medina
    • , Renata Sesti-Costa
    • , Grace K. Silva
    • , Carla D. Lopes
    • , Lucas E. Cardozo
    • , Fábio N. Gava
    • , Konstantina Lyroni
    • , Fabrício C. Dias
    • , Amanda F. Frade
    • , Monique Baron
    • , Helder I. Nakaya
    • , Florêncio Figueiredo
    • , José C. Alves-Filho
    • , Fernando Q. Cunha
    • , Christos Tsatsanis
    • , Christophe Chevillard
    • , Edecio Cunha-Neto
    • , Emilio Hirsch
    • , João S. Silva
    •  & Thiago M. Cunha
  • Article | | open

    Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.

    • Will J. R. Stone
    • , Joseph J. Campo
    • , André Lin Ouédraogo
    • , Lisette Meerstein-Kessel
    • , Isabelle Morlais
    • , Dari Da
    • , Anna Cohuet
    • , Sandrine Nsango
    • , Colin J. Sutherland
    • , Marga van de Vegte-Bolmer
    • , Rianne Siebelink-Stoter
    • , Geert-Jan van Gemert
    • , Wouter Graumans
    • , Kjerstin Lanke
    • , Adam D. Shandling
    • , Jozelyn V. Pablo
    • , Andy A. Teng
    • , Sophie Jones
    • , Roos M. de Jong
    • , Amanda Fabra-García
    • , John Bradley
    • , Will Roeffen
    • , Edwin Lasonder
    • , Giuliana Gremo
    • , Evelin Schwarzer
    • , Chris J. Janse
    • , Susheel K. Singh
    • , Michael Theisen
    • , Phil Felgner
    • , Matthias Marti
    • , Chris Drakeley
    • , Robert Sauerwein
    • , Teun Bousema
    •  & Matthijs M. Jore
  • Article | | open

    STING is an intracellular DNA sensor that can alter response to infection, but in the case of malaria it is unclear how parasite DNA in red blood cells (RBCs) reaches DNA sensors in immune cells. Here the authors show that STING in human monocytes can sense P. falciparum nucleic acids transported from infected RBCs via parasite extracellular vesicles.

    • Xavier Sisquella
    • , Yifat Ofir-Birin
    • , Matthew A. Pimentel
    • , Lesley Cheng
    • , Paula Abou Karam
    • , Natália G. Sampaio
    • , Jocelyn Sietsma Penington
    • , Dympna Connolly
    • , Tal Giladi
    • , Benjamin J. Scicluna
    • , Robyn A. Sharples
    • , Andreea Waltmann
    • , Dror Avni
    • , Eli Schwartz
    • , Louis Schofield
    • , Ziv Porat
    • , Diana S. Hansen
    • , Anthony T. Papenfuss
    • , Emily M. Eriksson
    • , Motti Gerlic
    • , Andrew F. Hill
    • , Andrew G. Bowie
    •  & Neta Regev-Rudzki
  • Article | | open

    Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.

    • John D. Chan
    • , Pauline M. Cupit
    • , Gihan S. Gunaratne
    • , John D. McCorvy
    • , Yang Yang
    • , Kristen Stoltz
    • , Thomas R. Webb
    • , Peter I. Dosa
    • , Bryan L. Roth
    • , Ruben Abagyan
    • , Charles Cunningham
    •  & Jonathan S. Marchant
  • Article | | open

    Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contribute to anaemia onset.

    • J. Rivera-Correa
    • , J. J. Guthmiller
    • , R. Vijay
    • , C. Fernandez-Arias
    • , M. A. Pardo-Ruge
    • , S. Gonzalez
    • , N. S. Butler
    •  & A. Rodriguez
  • Article | | open

    Host kinases facilitate Plasmodium liver stage (LS) infection, but systematic accounting of important players is lacking. Here, the authors use a computational approach and kinase activity profiles to identify host kinase regulators of LS infection and drugs that could eliminate parasite burden.

    • Nadia Arang
    • , Heather S. Kain
    • , Elizabeth K. Glennon
    • , Thomas Bello
    • , Denali R. Dudgeon
    • , Emily N. F. Walter
    • , Taranjit S. Gujral
    •  & Alexis Kaushansky
  • Article | | open

    Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a short period of time during the process.

    • Jason Pinger
    • , Shanin Chowdhury
    •  & F. Nina Papavasiliou
  • Article | | open

    Early-life microbiota alterations can affect infection susceptibility later in life, in animal models. Here, Knutie et al. show that manipulating the microbiota of tadpoles leads to increased susceptibility to parasitic infection in adult frogs, in the absence of substantial changes in the adults’ microbiota.

    • Sarah A. Knutie
    • , Christina L. Wilkinson
    • , Kevin D. Kohl
    •  & Jason R. Rohr
  • Article | | open

    Parasitemia has been considered the main determinant of visceral leishmaniasis transmission. By combining imaging, qPCR and experimental xenodiagnoses with mathematical models, Doehl et al. argue that the patchy landscape of parasites in the skin is necessary to explain infectiousness.

    • Johannes S. P. Doehl
    • , Zoe Bright
    • , Shoumit Dey
    • , Helen Davies
    • , John Magson
    • , Najmeeyah Brown
    • , Audrey Romano
    • , Jane E. Dalton
    • , Ana I. Pinto
    • , Jon W. Pitchford
    •  & Paul M. Kaye
  • Article | | open

    Cerebral malaria is an often fatal complication of Plasmodium infection involving accumulation of inflammatory leukocytes in the central nervous system. Here the authors map the development and trafficking of CCR5+ monocyte-derived dendritic cells from the spleen to the brains of Plasmodium berghei ANKA infected mice.

    • Isabella C. Hirako
    • , Marco A. Ataide
    • , Lucas Faustino
    • , Patricia A. Assis
    • , Elizabeth W. Sorensen
    • , Hisashi Ueta
    • , Natalia M. Araújo
    • , Gustavo B. Menezes
    • , Andrew D. Luster
    •  & Ricardo T. Gazzinelli
  • Article | | open

    Inflammatory response to malaria pathogen Plasmodium falciparum can be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.

    • Pierre-Yves Mantel
    • , Daisy Hjelmqvist
    • , Michael Walch
    • , Solange Kharoubi-Hess
    • , Sandra Nilsson
    • , Deepali Ravel
    • , Marina Ribeiro
    • , Christof Grüring
    • , Siyuan Ma
    • , Prasad Padmanabhan
    • , Alexander Trachtenberg
    • , Johan Ankarklev
    • , Nicolas M. Brancucci
    • , Curtis Huttenhower
    • , Manoj T. Duraisingh
    • , Ionita Ghiran
    • , Winston P. Kuo
    • , Luis Filgueira
    • , Roberta Martinelli
    •  & Matthias Marti
  • Article | | open

    Mice engrafted with human cells are useful models for research on human malaria parasites. Here the authors show that the complete life cycle of Plasmodium falciparum and the liver stages of Plasmodium ovale can be studied in mice doubly engrafted with human primary hepatocytes and red blood cells.

    • Valérie Soulard
    • , Henriette Bosson-Vanga
    • , Audrey Lorthiois
    • , Clémentine Roucher
    • , Jean- François Franetich
    • , Gigliola Zanghi
    • , Mallaury Bordessoulles
    • , Maurel Tefit
    • , Marc Thellier
    • , Serban Morosan
    • , Gilles Le Naour
    • , Frédérique Capron
    • , Hiroshi Suemizu
    • , Georges Snounou
    • , Alicia Moreno-Sabater
    •  & Dominique Mazier
  • Article | | open

    Microsporidia are intracellular parasitic fungi that infect diverse animal hosts including humans. Here, Desjardins et al. present genomic and transcriptomic data for two microsporidia that infect disease-transmitting mosquitoes, highlighting differences in potential host interplay mechanisms.

    • Christopher A. Desjardins
    • , Neil D. Sanscrainte
    • , Jonathan M. Goldberg
    • , David Heiman
    • , Sarah Young
    • , Qiandong Zeng
    • , Hiten D. Madhani
    • , James J. Becnel
    •  & Christina A Cuomo
  • Article |

    Nutrition can affect the outcome of infectious diseases through its effects on pathogens and/or host immunity. Here, Mejia et al. show that dietary restriction protects from experimental cerebral malaria in mice through its effects on leptin and mTORC1 in T cells.

    • Pedro Mejia
    • , J. Humberto Treviño-Villarreal
    • , Christopher Hine
    • , Eylul Harputlugil
    • , Samantha Lang
    • , Ediz Calay
    • , Rick Rogers
    • , Dyann Wirth
    • , Manoj T. Duraisingh
    •  & James R. Mitchell
  • Article |

    Trypanosomes, responsible for sleeping sickness, acquire haem through binding haptoglobin(Hp)–haemoglobin(Hb) complexes in human blood. Here Stødkilde et al. determine the structure of human Hp–Hb in complex with the Hp–Hb receptor from T. brucei and show that the recognition elements are shared by a protein complex on the surface of a trypanolytic lipoprotein particle.

    • Kristian Stødkilde
    • , Morten Torvund-Jensen
    • , Søren K. Moestrup
    •  & Christian B. F. Andersen