Pain is an unpleasant sensory and emotional experience. Acute nociceptive pain is induced by noxious stimuli, and is often a result of an intense or potentially damaging stimulus.

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News and Comment

  • Comments & Opinion |

    In the case that led the Supreme Court to overturn Roe vs Wade, the State of Mississippi made the strong claim that fetuses can feel pain. We argue that critical biological evidence used to support this claim was misinterpreted and that the State’s argument conflated pain and nociception. Abortion policy has profound moral and ethical consequences and therefore needs to be grounded in the most accurate scientific arguments, as well as a clear understanding of what we mean when we use the term pain.

    • T. V. Salomons
    •  & G. D. Iannetti
    Nature Neuroscience 25, 1396-1398
  • Research Highlights |

    A once-daily combination hormone treatment led to reductions in endometriosis-associated pain and opioid use for the duration of a 6-month study.

    • Karen O’Leary
  • Research Highlights |

    A study in mice reveals the neuronal mechanisms behind music-induced analgesia, providing a basis for further research and development of alternative pain interventions in humans.

    • Karen O’Leary
  • News & Views |

    Yang et al. demonstrate that sensory neurons are enriched for the anthrax toxin receptor-2. Edema toxin, which acts via this receptor, induces analgesia in mice and can also be engineered to deliver large cargoes such as botulinum toxin in order to selectively silence sensory neurons.

    • Jimena Perez-Sanchez
    •  & David L. Bennett
    Nature Neuroscience 25, 132-134