Featured
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Article |
A small and highly sensitive red/far-red optogenetic switch for applications in mammals
Highly sensitive photoswitchable dimerizer enables the control of biological processes with red light in mammals.
- Yang Zhou
- , Deqiang Kong
- & Haifeng Ye
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Article |
Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice
Optogenetics is applied to the entire mouse spinal cord.
- Claudia Kathe
- , Frédéric Michoud
- & Grégoire Courtine
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News & Views |
Tagging activated neurons with light
Two new protein tools translate neuronal activity into gene expression during a light-defined time window.
- Dheeraj S Roy
- , Teruhiro Okuyama
- & Susumu Tonegawa
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Letter |
A calcium- and light-gated switch to induce gene expression in activated neurons
Gene expression is controlled in activated neurons in the mouse brain using a two-component optogenetic system.
- Dongmin Lee
- , Jung Ho Hyun
- & Hyung-Bae Kwon
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News & Views |
Optogenetics unleashed
Two recent studies report the development of miniaturized, fully-implantable devices that enable wireless optogenetic neuromodulation in peripheral nerves and spinal cord.
- Polina Anikeeva
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Letter |
Optogenetic control of endogenous Ca2+ channels in vivo
A single-component optogenetic tool controls calcium fluxes with high dynamic range.
- Taeyoon Kyung
- , Sangkyu Lee
- & Won Do Heo
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Letter |
Photoactivatable CRISPR-Cas9 for optogenetic genome editing
The genome editing activity of CRISPR-Cas9 can be switched on and off by light using split Cas9 fragments fused tophotoinducible dimerization domains.
- Yuta Nihongaki
- , Fuun Kawano
- & Moritoshi Sato
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Letter |
Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model
Optogenetics helps unravel how neural cell grafts ameliorate symptoms in a mouse model of Parkinson's disease.
- Julius A Steinbeck
- , Se Joon Choi
- & Lorenz Studer
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Letter |
Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice
Viral delivery of opsins to peripheral nociceptors allows optogenetic stimulation and inhibition of pain in non-transgenic freely moving mice.
- Shrivats Mohan Iyer
- , Kate L Montgomery
- & Scott L Delp
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Editorial |
Enlightened engineering
Optogenetics—until now primarily a tool for asking questions in basic research—is starting to spur efforts oriented toward biomedical applications.
A red light–responsive photoswitch for deep tissue optogenetics