Oncology articles within Nature Medicine

Featured

  • Research Highlight |

    Researchers have developed a low-resource, environmentally friendly cancer-diagnosis platform that detects metabolites in dried serum spots.

    • Karen O’Leary

  • Research Highlight |

    In a head-to-head study, a multitarget version of the widely used FIT (fecal immunochemical test) showed a higher cancer detection rate than the standard test.

    • Karen O’Leary

  • Research Highlight |

    A quadrivalent vaccine against human papillomavirus produced by the Serum Institute of India was shown to be noninferior to the established quadrivalent vaccine — boosting global efforts to eliminate cervical cancer.

    • Karen O’Leary

  • Research Highlight |

    VX-548 selectively inhibits peripheral sodium channels to reduce acute pain, with potentially fewer safety concerns than for existing, nonselective blockers.

    • Karen O’Leary

  • Research Highlight |

    In a prospective study, artificial intelligence–assisted mammography screening had accuracy comparable to that of standard double reading — and substantially reduced radiologists’ workloads.

    • Karen O’Leary

  • Research Highlight |

    The dual IDH1–IDH2 inhibitor vorasidenib more than doubled time to progression (relative to placebo) and thus represents the first new treatment in decades for patients with glioma.

    • Karen O’Leary

  • Research Highlight |

    An antibody–drug conjugate showed impressive anti-cancer activity in selected patients with platinum-resistant ovarian cancer, and could become a new standard of care.

    • Karen O’Leary

  • Research Highlight |

    Two KRAS inhibitors that target the G12C mutation showed promising anti-tumor activity against metastatic colorectal cancer and pancreatic cancer, respectively, in early-phase trials.

    • Karen O’Leary

  • Research Highlight |

    Despite a reduction in colorectal cancer incidence, a large, randomized screening study shows no impact of screening on cancer-related deaths.

    • Karen O’Leary

  • Research Highlight |

    Matching genomic alterations to targeted therapies could unlock the benefits of precision medicine — but tools for interpreting genomic data are crucial.

    • Karen O’Leary

  • Research Highlight |

    The release of breast cancer cells into the circulation occurs mostly during rest — a surprising discovery that may help researchers to better study and target cancer metastasis.

    • Karen O’Leary

  • Research Highlight |

    Patients with HER2-low metastatic breast cancer are a historically overlooked group, but a phase 3 trial reveals trastuzumab deruxtecan as a new treatment option that prolongs survival.

    • Karen O’Leary

  • Research Highlight |

    Upadacitinib, a JAK inhibitor, may help patients with moderate to severely active ulcerative colitis obtain long-term control of the condition.

    • Karen O’Leary

  • Research Highlight |

    A rationally designed treatment for Creutzfeldt–Jakob disease — the first of its kind — appears to safely reach target levels in the brain, which provides justification for further clinical trials.

    • Karen O’Leary

  • Research Highlight |

    A WHO expert panel concluded that a single dose of HPV vaccine has efficacy comparable to that of the two-dose regimen, which could help boost cervical cancer–elimination efforts.

    • Karen O’Leary

  • Research Highlight |

    A phase 3 trial confirms that addition of the checkpoint inhibitor nivolumab to neoadjuvant chemotherapy improves outcomes in patients with early-stage lung cancer.

    • Karen O’Leary

  • Research Highlight |

    Trastuzumab deruxtecan performed better than trastuzumab emtansine in patients with pretreated HER2-positive metastatic breast cancer, but careful safety monitoring will be needed in the clinical setting.

    • Karen O’Leary

  • Research Highlight |

    The pandemic has limited access to endoscopy screening for patients with Barrett’s esophagus, but a new biomarker-based method could help prioritize patients based on cancer risk.

    • Karen O’Leary

  • Research Highlight |

    CAR-T cell therapies may represent a viable treatment for relapsed or refractory disease, but further studies will be needed to refine patient selection.

    • Karen O’Leary

  • Research Highlight |

    People with HIV who delay initiation of anti-retroviral therapy have permanent loss of memory T cells in the skin, which may explain their increased risk of skin cancer.

    • Karen O’Leary

  • Research Highlight |

    Selective RET inhibition shows promising anti-tumor activity in patients with RET fusion–positive NSCLC.

    • Karen O’Leary

  • Research Highlight |

    Gefitinib with lenvatinib shows promising antitumor activity in patients whose cancers had progressed on lenvatinib monotherapy.

    • Karen O’Leary

  • Research Highlight |

    For patients with early-stage breast cancer and a high risk of recurrence, addition of the PARP inhibitor olaparib to standard treatments reduced the risk of the cancer returning.

    • Karen O’Leary

  • Research Highlight |

    Anti-PD-1 after surgery improves the survival of patients with esophageal cancers in a clinical trial.

    • Saheli Sadanand

  • Research Highlight |

    Engineered T cells that recognize a protein expressed on myeloma cells show promise in a clinical trial.

    • Saheli Sadanand

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