Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

siRNA delivery

Loaded-up microsponges

Nature Materials volume 11, pages 268–269 (2012)Cite this article

Subjects

Self-assembled microsponges of hairpin RNA polymers achieve, with one thousand times lower concentration, the same degree of gene silencing in tumour-carrying mice as conventional nanoparticle-based siRNA delivery vehicles.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic outlining the one-pot synthesis of polymers of short double-stranded RNA (dsRNA) hairpins and their spontaneous assembly, over approximately 20 h, into 2-μm-diameter RNAi microsponges through a series of intermediate structures1.
Figure 2: Complementary strategies to generate multifunctional RNA nanoparticles.

References

  1. Lee, J. B., Hong, J., Bonner, D. K., Poon, Z. & Hammond, P. T. Nature Mater. 11, 316–322 (2012).

    Article  CAS  Google Scholar 

  2. Grabow, W. W. et al. Nano Lett. 11, 878–887 (2011).

    Article  CAS  Google Scholar 

  3. Severcan, I. et al. Nature Chem. 2, 772–779 (2010).

    Article  CAS  Google Scholar 

  4. Afonin, K. A. et al. Natur Nanotech. 5, 676–682 (2010).

    Article  CAS  Google Scholar 

  5. Shu, D., Shu, Y., Haque, F., Abdelmawla, S. & Guo, P. Nature Nanotech. 6, 658–667 (2011).

    Article  CAS  Google Scholar 

  6. Afonin, K. A. et al. Nature Protoc. 6, 2022–2034 (2011).

    Article  CAS  Google Scholar 

  7. Pecot, C. V., Calin, G. A., Coleman, R. L., Lopez-Berestein, G. & Sood, A. K. Nature Rev. Cancer 11, 59–67 (2011).

    Article  CAS  Google Scholar 

  8. Davis, M. E. et al. Nature 464, 1067–1070 (2010).

    Article  CAS  Google Scholar 

  9. Shukla, G. C. et al. ACS Nano 5, 3405–3418 (2011).

    Article  CAS  Google Scholar 

  10. Douglas, S. M., Bachelet, I. & Church, G. M. Science 335, 831–834 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106-9510, California, USA

    Wade W. Grabow & Luc Jaeger

  2. Biomolecular Science and Engineering Program, University of California, Santa Barbara, 93106-9510, California, USA

    Luc Jaeger

Authors
  1. Wade W. Grabow
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luc Jaeger
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Luc Jaeger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grabow, W., Jaeger, L. Loaded-up microsponges. Nature Mater 11, 268–269 (2012). https://doi.org/10.1038/nmat3286

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat3286

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing