Featured
-
-
Article
| Open AccessNeural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression.
- Zina Dubeykovskaya
- , Yiling Si
- & Timothy C. Wang
-
Article
| Open AccessGABAergic interneurons form transient layer-specific circuits in early postnatal neocortex
GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.
- Paul G. Anastasiades
- , Andre Marques-Smith
- & Simon J. B. Butt
-
Article
| Open AccessPresynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo
Neurons in the zebrafish retina regenerate. Here, Yoshimatsu and colleagues show that retinal horizontal cells maintain their synaptic preferences for a limited period before circuit remodeling is triggered after photoreceptor loss.
- Takeshi Yoshimatsu
- , Florence D. D’Orazi
- & Rachel O. Wong
-
Article
| Open AccessHuman brain networks function in connectome-specific harmonic waves
Inter-areal oscillatory synchronization is constrained by anatomical connections, yet a fundamental principle linking functional and structural connectivity is lacking. Here, Atasoy and colleagues show that harmonic patterns in structural connectome can predict dynamics of resting state networks.
- Selen Atasoy
- , Isaac Donnelly
- & Joel Pearson
-
Article
| Open AccessAn excitatory ventral hippocampus to lateral septum circuit that suppresses feeding
The ventral hippocampus connects to the hypothalamus and has been implicated in feeding behaviours. Here, the authors use a combination of optogenetics and DREADD strategies to dissect the underlying circuit, showing that projections from the vHC to the lateral septum work to regulate feeding suppression.
- Patrick Sweeney
- & Yunlei Yang
-
Article
| Open AccessInterneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory–inhibitory synapse formation in the mature cortex
Neuregulin-1 and DISC1 signalling pathways have both been linked to neurodevelopment and schizophrenia. Here, Seshadri et al. demonstrate that DISC1 negatively regulates NRG1-induced ErbB4 signalling in adult cortical interneurons both in vitro and in vivo, possibly via competitive binding to PSD95.
- Saurav Seshadri
- , Travis Faust
- & Akira Sawa
-
Article
| Open AccessCold-sensing regulates Drosophila growth through insulin-producing cells
Animal body size is influenced by climate, but the cellular mechanisms regulating this response are unclear. Here, the authors identify a neuronal circuit composed of a group of cold-sensing neurons and insulin-producing cells that mediates the effects of temperature onDrosophilagrowth.
- Qiaoran Li
- & Zhefeng Gong
-
Article
| Open AccessDynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation
The ability to map the activity of synapses within a circuit will help in elucidating the neural basis of behaviour. Here, Macpherson et al. report new strategies to specifically label active synapses in Drosophila with multi-colour fluorescence tags.
- Lindsey J. Macpherson
- , Emanuela E. Zaharieva
- & Marco Gallio
-
Article
| Open AccessRestoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3
A key pathological alteration after brain and spinal cord injury is the disruption of the corticospinal tract (CST) axons that control the voluntary movements. Here the authors show that activating the intrinsic regenerative ability by inhibiting PTEN and SOCS3 expression promotes robust sprouting growth and recovery of skilled locomotion after injury.
- Duo Jin
- , Yuanyuan Liu
- & Zhigang He
-
Article
| Open AccessThe neural dynamics of sensory focus
Animals tracking objects can adapt their movements to optimise sensory coding. Using fish that sense objects as perturbations to an electric field, Clarke et al. reveal that the optimal object distance maintained by the fish is encoded within the firing properties of electrosensory neurons.
- Stephen E. Clarke
- , André Longtin
- & Leonard Maler
-
Article
| Open AccessDilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing
The orphan ligand Dilp8 has been shown to coordinate growth and developmental timing in Drosophila. Here, using Gal4 drivers and CRISPR/Cas9 approaches, Garelli et al.identify a role for relaxin-like receptor Lgr3 in regulating the Dilp8 developmental delay pathway.
- Andres Garelli
- , Fabiana Heredia
- & Alisson M. Gontijo
-
Article
| Open AccessControllability of structural brain networks
Cognitive control is fundamental to human intelligence, yet the principles constraining the neural dynamics of cognitive control remain elusive. Here, the authors use network control theory to demonstrate that the structure of brain networks dictates their functional role in controlling dynamics.
- Shi Gu
- , Fabio Pasqualetti
- & Danielle S. Bassett
-
Article
| Open AccessAn insula-frontostriatal network mediates flexible cognitive control by adaptively predicting changing control demands
The ability to continually adjust behavioural strategies is a hallmark of human cognition, yet the underlying mechanisms remain poorly understood. Here the authors show that an insula-frontostriatal network mediates such flexible cognitive control by adaptively predicting changing control demands.
- Jiefeng Jiang
- , Jeffrey Beck
- & Tobias Egner
-
Article
| Open AccessSonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans
Common optogenetic approaches require surgical procedures to deliver light of specific wavelengths to the target cells. Here the authors demonstrate the use of low-pressure ultrasound as a non-invasive trigger to activate specific neurons in Caenorhabditis elegansand find that the mechanotransduction channel TRP-4 sensitizes cells to the ultrasound stimulus.
- Stuart Ibsen
- , Ada Tong
- & Sreekanth H. Chalasani
-
Article
| Open AccessLarge-volume en-bloc staining for electron microscopy-based connectomics
Large-scale dense reconstruction of neuronal circuits (or connectomics) requires methods for large-volume dense en-blocelectron microscopy (EM) staining. Here the authors develop a protocol for staining tissue blocks from mouse neocortex sized at least 1 mm in diameter, enabling correlated functional and structural circuit analyses.
- Yunfeng Hua
- , Philip Laserstein
- & Moritz Helmstaedter
-
Article
| Open AccessTransient brain activity disentangles fMRI resting-state dynamics in terms of spatially and temporally overlapping networks
Growing evidence from neuroimaging studies suggests that the brain is dynamically organized into functionally connected networks. Here, the authors develop a new technique for decomposing spontaneous activity into temporally overlapping building blocks that assemble standard functional networks.
- Fikret Işik Karahanoğlu
- & Dimitri Van De Ville
-
Article
| Open AccessParallel circuits control temperature preference in Drosophila during ageing
The capacity for thermoregulation deteriorates with age, particularly in cold environments. Here the authors demonstrate inDrosophilathat age-related changes in cold avoidance result from a shift in the relative contribution of two parallel mushroom body circuits that are modulated by dopamine.
- Hsiang-Wen Shih
- , Chia-Lin Wu
- & Ann-Shyn Chiang
-
Article
| Open AccessAuditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus
Defense against environmental threats is essential for survival, yet the neural circuits mediating innate defensive behaviours are not completely understood. Here the authors demonstrate that descending projections from the auditory cortex to the midbrain mediate innate, sound-evoked flight behaviour.
- Xiaorui R. Xiong
- , Feixue Liang
- & Li I. Zhang
-
Article
| Open AccessA negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling
The neuregulin receptor ErbB4 is an important modulator of GABAergic interneurons and neural network synchronization but little is known about the endogenous ligands that engage ErbB4 and the downstream targets. Here the authors describe the existence of a cell-autonomous bidirectional pathway that links NMDA receptor activity with NRG signalling in GABAergic interneurons.
- Detlef Vullhorst
- , Robert M. Mitchell
- & Andres Buonanno
-
Article
| Open AccessDiverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks
The brain exhibits a diversity of plasticity mechanisms across different timecales that constitute the putative basis for learning and memory. Here, the authors demonstrate how these different plasticity mechanisms are orchestrated to support the formation of robust and stable neural cell assemblies.
- Friedemann Zenke
- , Everton J. Agnes
- & Wulfram Gerstner
-
Article |
A causal role of the right inferior frontal cortex in implementing strategies for multi-component behaviour
Complex behaviours, such as driving a car, require the organization and processing of several individual actions. Here, the authors use transcranial magnetic stimulation to demonstrate that the right inferior frontal gyrus determines the strategy used to sequence actions during complex behaviours.
- Gabriel Dippel
- & Christian Beste
-
Article
| Open AccessChoice-correlated activity fluctuations underlie learning of neuronal category representation
The ability to categorize stimuli into discrete behaviourally relevant groups is an essential cognitive function. Here, the authors demonstrate a critical role for choice-correlated activity fluctuations in the emergence of stable cortical category representations.
- Tatiana A. Engel
- , Warasinee Chaisangmongkon
- & Xiao-Jing Wang
-
Article |
The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion
Persistent neural activity underlies working memories and behaviors that require short-term information retention; the mechanisms enabling this, however, are unclear. Here the authors show that the NCA Na+ leak channel is required for the persistent motor circuit activity that sustains locomotion in C. elegans.
- Shangbang Gao
- , Lin Xie
- & Mei Zhen
-
Article |
Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery
In response to spinal cord injuries, limited functional recovery can be achieved but the new circuits that arise have not been characterized in detail. Here the authors show that synaptic connections between the ascending proprioceptive neurons and a small number of spared dorsal column neurons, can be remodeled after a cervical lesion to support functional recovery.
- Edmund R. Hollis II
- , Nao Ishiko
- & Yimin Zou
-
Article |
Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans
In Caenorhabditis elegans, nociception and avoidance behaviour are crucial for survival, but their modulation is poorly understood. Here, the authors describe a cross-inhibitory neural circuit between ASH and ASI sensory neurons that fine-tunes nociception and mediates adaptive avoidance behaviour.
- Min Guo
- , Tai-Hong Wu
- & Zheng-Xing Wu
-
Article |
A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins
The brain has a central role in the regulation of organismal energy homeostasis. Here the authors show that neurons in the mediobasal hypothalamus respond to fatty acids by generating neuronal signals, relayed to the liver viavagal nerves that mediate secretion of very-low-density lipoproteins.
- Jessica T. Y. Yue
- , Mona A. Abraham
- & Tony K. T. Lam
-
Article |
Information flow through neural circuits for pheromone orientation
In silkmoths, pheromones are used to find food, to evade predators and to locate mating partners. In this study, Namiki et al.use anatomical and electrophysiological approaches to identify four neural circuits that contribute to a neural pathway for pheromone processing in the protocerebrum of silkmoths.
- Shigehiro Namiki
- , Satoshi Iwabuchi
- & Ryohei Kanzaki
-
Article
| Open AccessVAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans
VAV proteins are guanine nucleotide exchange factors that have various neuromodulatory roles in the nervous system. Here, Fry et al. show that in Caenorhabditis elegans, VAV-1 negatively regulates locomotor speed and only needs to be expressed in a specific interneuron to do so.
- Amanda L. Fry
- , Jocelyn T. Laboy
- & Kenneth R. Norman
-
Article
| Open AccessRewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans
Neural circuits are functional ensembles of neurons that are selectively interconnected by chemical or electrical synapses. Here the authors describe an approach to the study of neural circuits in C. eleganswhereby electrical synapses are introduced between previously unconnected neurons to reprogram behaviour.
- Ithai Rabinowitch
- , Marios Chatzigeorgiou
- & William R. Schafer