Neural ageing articles within Nature

Featured

  • Article
    | Open Access

    A neuron-specific activity-dependent DNA repair mechanism is identified, the impairment of which may lead to neurodevelopmental disorders, neurodegeneration and ageing.

    • Elizabeth A. Pollina
    • , Daniel T. Gilliam
    •  & Michael E. Greenberg

  • Article |

    A molecular mechanism involving CCR5 and CCL5 determines the temporal window in which a memory can be linked with subsequent memories, and in aged mice an increase in CCR5 is associated with defects in memory linking.

    • Yang Shen
    • , Miou Zhou
    •  & Alcino J. Silva

  • Article
    | Open Access

    MRI data from more than 100 studies have been aggregated to yield new insights about brain development and ageing, and create an interactive open resource for comparison of brain structures throughout the human lifespan, including those associated with neurological and psychiatric disorders.

    • R. A. I. Bethlehem
    • , J. Seidlitz
    •  & A. F. Alexander-Bloch

  • Article |

    Two epigenetic regulators—identified in an RNA interference screen in Caenhorhabditis elegans, and conserved in mammals—diminish mitochondrial function and accelerate the age-related deterioration of behaviour.

    • Jie Yuan
    • , Si-Yuan Chang
    •  & Shi-Qing Cai

  • Article |

    Studies of humans, mice and nematodes reveal a conserved role of neural activity and the transcription factor REST in extended longevity.

    • Joseph M. Zullo
    • , Derek Drake
    •  & Bruce A. Yankner

  • Article |

    Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases.

    • Sandro Da Mesquita
    • , Antoine Louveau
    •  & Jonathan Kipnis

  • Article |

    Identifying the gene polymorphisms that are the foundations of variation in glia–neuron signalling in Caenorhabditis elegans provides insight into highly variable age-related declines in worm behaviours.

    • Jiang-An Yin
    • , Ge Gao
    •  & Shi-Qing Cai

  • Brief Communication |

    • John Collinge
    • , Zane Jaunmuktane
    •  & Sebastian Brandner

  • Article |

    REST, a developmental regulator, is markedly induced in human neurons during ageing but is lost in Alzheimer’s disease; REST represses genes that promote neurodegeneration, is neuroprotective in animal models, and is associated with cognitive preservation and longevity in humans.

    • Tao Lu
    • , Liviu Aron
    •  & Bruce A. Yankner

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