Molecular Diagnostics
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Open Access
Featured
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Genetics and Genomics
| Open AccessAn intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing
- S Sandell
- , R J L Schuit
- & D J Bunyan
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Molecular Diagnostics
| Open AccessImmunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations
- D J Pinato
- , R Ramachandran
- & T M Tan
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Molecular Diagnostics
| Open AccessKRAS mutational status affects oxaliplatin-based chemotherapy independently from basal mRNA ERCC-1 expression in metastatic colorectal cancer patients
- M Basso
- , A Strippoli
- & C Barone
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Genetics and Genomics
| Open AccessThe incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
- J Iqbal
- , A Ragone
- & S A Narod
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Molecular Diagnostics
| Open AccessCarcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma
- M Kobayashi
- , Y Miki
- & H Sasano
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Genetics and Genomics
| Open AccessKRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
- E Birkeland
- , E Wik
- & H B Salvesen
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Molecular Diagnostics
| Open AccessEGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors?
- A Paliga
- , R Onerheim
- & T Vuong
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Genetics and Genomics
| Open AccessBasal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection
- C-M Chu
- , C-C Lin
- & Y-F Liaw
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Molecular Diagnostics
| Open AccessPotential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway
- H Joshi
- , G Bhanot
- & V Kristensen
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Molecular Diagnostics
| Open AccessThe utility of molecular diagnostics to predict recurrence of head and neck carcinoma
- C Pena Murillo
- , X Huang
- & M Partridge
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Molecular Diagnostics
| Open AccessKRAS mutations in primary tumours and post-FOLFOX metastatic lesions in cases of colorectal cancer
- Y Kawamoto
- , K Tsuchihara
- & A Ohtsu
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Clinical Study
| Open AccessLong-term results of screening with magnetic resonance imaging in women with BRCA mutations
- K Passaperuma
- , E Warner
- & S A Narod
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Translational Therapeutics
| Open AccessImpact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells
- U Stein
- , C Fleuter
- & W Walther
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Molecular Diagnostics
| Open AccessImpact of genomic stability on protein expression in endometrioid endometrial cancer
- M I Lomnytska
- , S Becker
- & G Auer
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Clinical Study
| Open AccessMulticentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer
- J Harder
- , G Ihorst
- & M Geissler
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Molecular Diagnostics
| Open AccessFGFR2 gene amplification and clinicopathological features in gastric cancer
- K Matsumoto
- , T Arao
- & Y Yamada
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Molecular Diagnostics
| Open AccessDifferential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification
- J Tanizaki
- , I Okamoto
- & K Nakagawa
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Molecular Diagnostics
| Open AccessPyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours
- S Weidlich
- , K Walsh
- & G Smith
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Letter to the Editor
| Open AccessStability of BRAF V600E mutation in metastatic melanoma: new insights for therapeutic success?
- L Sigalotti
- , E Fratta
- & M Maio
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Molecular Diagnostics
| Open AccessPromoter methylation of Wnt5a is associated with microsatellite instability and BRAF V600E mutation in two large populations of colorectal cancer patients
- J B Rawson
- , M Mrkonjic
- & B Bapat
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Epidemiology
| Open AccessBody mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes
- A K Win
- , J G Dowty
- & M A Jenkins
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Short Communication
| Open AccessGlioma cells showing IDH1 mutation cannot be propagated in standard cell culture conditions
- S Piaskowski
- , M Bienkowski
- & P Rieske
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Molecular Diagnostics
| Open AccessPolyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression
- J Lin
- , Y Goto
- & M Takata
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Molecular Diagnostics
| Open AccessTumours with loss of MSH6 expression are MSI-H when screened with a pentaplex of five mononucleotide repeats
- J-F You
- , O Buhard
- & R Hamelin
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Molecular Diagnostics
| Open AccessKRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis
- V Deschoolmeester
- , C Boeckx
- & J B Vermorken
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Translational Therapeutics
| Open AccessEstablishment and characterisation of a new breast cancer xenograft obtained from a woman carrying a germline BRCA2 mutation
- L de Plater
- , A Laugé
- & E Marangoni
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Epidemiology
| Open AccessIncreased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations
- G S Dite
- , A S Whittemore
- & J L Hopper
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Molecular Diagnostics
| Open AccessBRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients’ outcome
- Z Saridaki
- , D Papadatos-Pastos
- & J Souglakos
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Molecular Diagnostics
| Open AccessImproving the yield of circulating tumour cells facilitates molecular characterisation and recognition of discordant HER2 amplification in breast cancer
- L M Flores
- , D W Kindelberger
- & I E Krop
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Short Communication
| Open AccessE17K substitution in AKT1 in prostate cancer
- J L Boormans
- , H Korsten
- & J Trapman
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Molecular Diagnostics
| Open AccessPrediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous cell carcinoma
- H Takeshita
- , D Ichikawa
- & E Otsuji
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Clinical Study
| Open AccessClinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT
- D Handolias
- , A L Hamilton
- & G A McArthur
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Clinical Study
| Open AccessLong-term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1/BRCA2/TP53 status
- D G R Evans
- , A Moran
- & F Lalloo
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Letter to the Editor
| Open AccessReply: KRAS status analysis and anti-EGFR therapies: is comprehensiveness a biologist's fancy or a clinical necessity?
- C Cremolini
- , A Ruzzo
- & F Loupakis
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Translational Therapeutics
| Open AccessActivating K-Ras mutations outwith ‘hotspot’ codons in sporadic colorectal tumours – implications for personalised cancer medicine
- G Smith
- , R Bounds
- & C R Wolf
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Translational Therapeutics
| Open Accessp53 mutation, deprivation and poor prognosis in primary breast cancer
- L Baker
- , P R Quinlan
- & A M Thompson