Monosaccharides articles within Nature Communications

Featured

• Article
  10 July 2023 | Open Access

  Establishing mammalian GLUT kinetics and lipid composition influences in a reconstituted-liposome system

  Transport assays using purified glucose transporters (GLUTs) have proven to be difficult to implement, hampering deeper mechanistic insights. Here the authors have optimized a transport assay in liposomes that will provide insight to study other membrane transport proteins.

  • Albert Suades
  • , Aziz Qureshi
  •  & David Drew

• Article
  23 June 2022 | Open Access

  Engineering substrate specificity of HAD phosphatases and multienzyme systems development for the thermodynamic-driven manufacturing sugars

  Haloacid dehalogenase-like phosphatases are widespread across all domains of life and play a crucial role in the regulation of levels of sugar phosphate metabolites in cells. The authors report on the structure-guided engineering of phosphatases for dedicated substrate specificity for the conversion of sucrose and starch into fructose and mannose.

  • Chaoyu Tian
  • , Jiangang Yang
  •  & Yanhe Ma

• Article
  02 December 2021 | Open Access

  Fluorinated rhamnosides inhibit cellular fucosylation

  Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation metabolic prodrug inhibitors and demonstrated inhibition of cellular fucosylation.

  • Johan F. A. Pijnenborg
  • , Emiel Rossing
  •  & Thomas J. Boltje

• Article
  24 January 2019 | Open Access

  Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily

  Plants are dependent on controlled sugar uptake via Monosaccharide Transporters, such as STP10, for correct organ development, sugar accumulation in fruits and microbial defense. Here authors present the crystal structure of STP10 bound to glucose which sheds light on the fundamental principles of sugar transport in the plant-unique MST superfamily.

  • Peter Aasted Paulsen
  • , Tânia F. Custódio
  •  & Bjørn Panyella Pedersen

• Article
  09 November 2018 | Open Access

  A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

  Polyfluorinated hexopyranoses display unique physical, chemical and biological properties, however their stereoselective synthesis is highly challenging. Here, the authors report a synthetic approach based on the chemical manipulation of inexpensive levoglucosan to obtain heavily fluorinated monosaccharides stereoselectively.

  • Vincent Denavit
  • , Danny Lainé
  •  & Denis Giguère

• Article
  20 April 2017 | Open Access

  Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications

  N-acetyl-muramic acid (NAM) is a core component of the bacterial peptidoglycan (PG) cell wall, and is recognised by the innate immune system. Here the authors engineer Gram-negative and Gram-positive bacteria to incorporate a modified NAM into the backbone of PG, which can be labelled with click chemistry for imaging and tracking.

  • Hai Liang
  • , Kristen E. DeMeester
  •  & Catherine L. Grimes

• Article
  11 March 2016 | Open Access

  Hexose enhances oligonucleotide delivery and exon skipping in dystrophin-deficient mdx mice

  Exon-skipping therapies such as systemic i.v. administration of morpholino are being explored as a means of treating Duchenne muscular dystrophy. Here the authors show that adding a glucose-fructose mix can enhance uptake of phosphorodiamidate morpholino oligomer and its therapeutic effect in mdxmice.

  • Gang Han
  • , Ben Gu
  •  & HaiFang Yin