Molecular biophysics

Molecular biophysics is the study of the physical principles governing biomolecular systems. It seeks to explain biological function in terms of molecular structure, dynamics and organization, from single molecules to supramolecular structures.

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  • Research | | open

    Much of science revolves around predicting the future and retrodicting the past. In this study, the authors develop a theoretical framework that prescribes how the transition rates of a generic stochastic system should be perturbed so that the system becomes more susceptible to prediction or retrodiction, and demonstrate their method on two concrete systems: diffusion on a random network, and a thermalizing quantum harmonic oscillator.

    • Nathaniel Rupprecht
    •  & Dervis Can Vural
  • Research |

    High-throughput computation is especially useful for materials screening where synthesis is challenging. Here, it is used to construct a stability map of ternary nitrides, allowing discovery of stable compounds and providing insight into principles that govern nitride stability.

    • Wenhao Sun
    • , Christopher J. Bartel
    • , Elisabetta Arca
    • , Sage R. Bauers
    • , Bethany Matthews
    • , Bernardo Orvañanos
    • , Bor-Rong Chen
    • , Michael F. Toney
    • , Laura T. Schelhas
    • , William Tumas
    • , Janet Tate
    • , Andriy Zakutayev
    • , Stephan Lany
    • , Aaron M. Holder
    •  & Gerbrand Ceder
    Nature Materials 18, 732-739
  • Research | | open

    Correlations in quantum thermodynamics are usually regarded as a useful but expensive resource. Here, the authors prove that the work cost of generating multiple copies of a state is lower if the copies are correlated, pointing out at the irreversibility of the process in the single-shot regime.

    • Facundo Sapienza
    • , Federico Cerisola
    •  & Augusto J. Roncaglia
  • Research | | open

    RNA chaperones, such as the hepatitic C virus (HCV) core protein, are proteins that aid in the folding of nucleic acids. Here authors use single‐molecule spectroscopy and simulation to show that the HCV core protein acts as a flexible macromolecular counterion which facilitates nucleic acid folding.

    • Erik D. Holmstrom
    • , Zhaowei Liu
    • , Daniel Nettels
    • , Robert B. Best
    •  & Benjamin Schuler

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