Translational Therapeutics
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Open Access
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Genetics and Genomics
| Open AccessSite-specific CpG methylation in the CCAAT/enhancer binding protein delta (CEBPδ) CpG island in breast cancer is associated with metastatic relapse
- C Palmieri
- , M Monteverde
- & T Crook
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Molecular Diagnostics
| Open AccessAccurate and rapid novel genetic diagnosis for detection of sentinel lymph node metastasis in breast cancer patients
- H Iinuma
- , J Tamura
- & T Ikeda
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Clinical Study
| Open AccessSerum markers lactate dehydrogenase and S100B predict independently disease outcome in melanoma patients with distant metastasis
- B Weide
- , M Elsässer
- & C Garbe
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Molecular Diagnostics
| Open AccessSecreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation
- A Sadanandam
- , S S Sidhu
- & R K Singh
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Clinical Study
| Open AccessSorafenib in advanced melanoma: a critical role for pharmacokinetics?
- N Pécuchet
- , C Lebbe
- & F Goldwasser
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Molecular Diagnostics
| Open AccessAkt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β3 affinity modulation
- A Goc
- , J Liu
- & P R Somanath
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Clinical Study
| Open AccessPatterns of metastasis in women with metachronous contralateral breast cancer
- V Vichapat
- , H Garmo
- & M Lüchtenborg
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Molecular Diagnostics
| Open AccessCisplatin plus paclitaxel and maintenance of bevacizumab on tumour progression, dissemination, and survival of ovarian carcinoma xenograft models
- P Oliva
- , A Decio
- & R Giavazzi
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Molecular Diagnostics
| Open AccessmiR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer
- J Zhang
- , Z Xiao
- & J Wang
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Clinical Study
| Open AccessClinical relevance of circulating CK-19mRNA-positive tumour cells before front-line treatment in patients with metastatic breast cancer
- N Androulakis
- , S Agelaki
- & V Georgoulias
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Molecular Diagnostics
| Open AccessMethylation of the calcium channel regulatory subunit α2δ-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas
- C Palmieri
- , B Rudraraju
- & T Crook
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Molecular Diagnostics
| Open AccessInhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis
- D M Ray
- , P H Myers
- & J D Roberts
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Translational Therapeutics
| Open AccessTargeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo
- B Gibert
- , B Eckel
- & C Diaz-Latoud
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Clinical Study
| Open AccessValue of DCE-MRI and FDG-PET/CT in the prediction of response to preoperative chemotherapy with bevacizumab for colorectal liver metastases
- S De Bruyne
- , N Van Damme
- & M Peeters
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Clinical Study
| Open AccessEpithelial–mesenchymal transition biomarkers and support vector machine guided model in preoperatively predicting regional lymph node metastasis for rectal cancer
- X-J Fan
- , X-B Wan
- & J-P Wang
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Short Communication
| Open AccessIncidence and time trends of brain metastases admissions among breast cancer patients in Sweden
- G Frisk
- , T Svensson
- & K E Smedby
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Short Communication
| Open AccessCorrelation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection
- A Dewdney
- , D Cunningham
- & I Chau
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Molecular Diagnostics
| Open AccessThe differential effects of statins on the metastatic behaviour of prostate cancer
- M Brown
- , C Hart
- & N Clarke
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Molecular Diagnostics
| Open AccessPI3K/Akt signalling is required for the attachment and spreading, and growth in vivo of metastatic scirrhous gastric carcinoma
- T Matsuoka
- , M Yashiro
- & J D Roberts
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Molecular Diagnostics
| Open AccessIncidence and possible pathogenesis of sentinel node micrometastases in ductal carcinoma in situ of the breast detected using molecular whole lymph node assay
- T Osako
- , T Iwase
- & F Akiyama
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Translational Therapeutics
| Open AccessPPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice
- B Shen
- , E S H Chu
- & J Yu
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Clinical Study
| Open AccessEffectiveness and cost-effectiveness of sentinel lymph node biopsy compared with axillary node dissection in patients with early-stage breast cancer: a decision model analysis
- H Verry
- , S J Lord
- & J Simes
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Clinical Study
| Open AccessRepeated transarterial chemoembolisation using different chemotherapeutic drug combinations followed by MR-guided laser-induced thermotherapy in patients with liver metastases of colorectal carcinoma
- T J Vogl
- , A Jost
- & N N N Naguib
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Molecular Diagnostics
| Open AccessPrognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study
- S Thomas
- , C Pütter
- & M Zeschnigk
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Clinical Study
| Open AccessA phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
- N Steele
- , A Anthony
- & J Cassidy
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Clinical Study
| Open AccessRandomised phase-II trial of CAPIRI (capecitabine, irinotecan) plus bevacizumab vs FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) plus bevacizumab as first-line treatment of patients with unresectable/metastatic colorectal cancer (mCRC)
- J Souglakos
- , N Ziras
- & A Polyzos
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Clinical Study
| Open AccessBrain metastases free survival differs between breast cancer subtypes
- A Berghoff
- , Z Bago-Horvath
- & R Bartsch
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Clinical Study
| Open AccessCetuximab-based therapy in elderly comorbid patients with metastatic colorectal cancer
- C F Jehn
- , L Böning
- & D Lüftner
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Mini Review
| Open AccessNotch signalling in cancer progression and bone metastasis
- N Sethi
- & Y Kang
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Molecular Diagnostics
| Open AccessExpression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients’ survival
- J Ren
- , W Li
- & Z Xu
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Molecular Diagnostics
| Open AccessTYRP1 mRNA expression in melanoma metastases correlates with clinical outcome
- F Journe
- , H Id Boufker
- & G Ghanem
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Translational Therapeutics
| Open AccessInhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
- E Arai
- , Y Nishida
- & N Ishiguro
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Molecular Diagnostics
| Open AccessmiRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215
- N M A White
- , H W Z Khella
- & G M Yousef
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Molecular Diagnostics
| Open AccessHost-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production
- H Fukuda
- , S Mochizuki
- & Y Okada
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Molecular Diagnostics
| Open AccessLow ANXA10 expression is associated with disease aggressiveness in bladder cancer
- P P Munksgaard
- , F Mansilla
- & L Dyrskjøt
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Short Communication
| Open AccessDetection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer
- A Lecharpentier
- , P Vielh
- & F Farace
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Clinical Study
| Open AccessPrognostic discrimination of subgrouping node-positive endometrioid uterine cancer: location vs nodal extent
- D S Kapp
- , T K Kiet
- & J K Chan
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Molecular Diagnostics
| Open AccessGSTPi-positive tumour microenvironment-associated fibroblasts are significantly associated with GSTPi-negative cancer cells in paired cases of primary invasive breast cancer and axillary lymph node metastases
- B Chaiwun
- , N Sukhamwang
- & S A Imam
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Molecular Diagnostics
| Open AccessAccurate staging of axillary lymph nodes from breast cancer patients using a novel molecular method
- T Osako
- , T Iwase
- & F Akiyama
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Molecular Diagnostics
| Open AccessA direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas
- F Farace
- , C Massard
- & P Vielh
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Clinical Study
| Open AccessPrognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary
- H Mahdi
- , R E Swensen
- & A R Munkarah
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Molecular Diagnostics
| Open AccessHigh FOXP3+ regulatory T-cell density in the sentinel lymph node is associated with downstream non-sentinel lymph-node metastasis in gastric cancer
- H E Lee
- , D J Park
- & H S Lee
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Genetics and Genomics
| Open AccessExpression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma
- H Adwan
- , M Zhivkova-Galunska
- & M R Berger
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Genetics and Genomics
| Open AccessMolecular alterations associated with liver metastases development in colorectal cancer patients
- S C Bruin
- , Y He
- & L J van ‘t Veer
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Molecular Diagnostics
| Open AccessNF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells
- C Vonach
- , K Viola
- & G Krupitza
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Clinical Study
| Open AccessCentral nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens
- V Chiarion-Sileni
- , M Guida
- & G L De Salvo
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Clinical Study
| Open AccessRecurrence and survival after pathologic complete response to preoperative therapy followed by surgery for gastric or gastrooesophageal adenocarcinoma
- R C Fields
- , V E Strong
- & M A Shah
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Short Communication
| Open AccessVascular phenotypes in primary non-small cell lung carcinomas and matched brain metastases
- A M Jubb
- , A Cesario
- & F Pezzella
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Clinical Study
| Open AccessComparison of HER2 status in primary and paired metastatic sites of gastric carcinoma
- C Bozzetti
- , F V Negri
- & A Ardizzoni