Melanoma

Melanoma is the most serious type of skin cancer. It develops when skin cells multiply rapidly as a consequence of mutations in their DNA caused by UV exposure. Melanomas originate in the pigment-producing melanocytes in the basal layer of the epidermis; they often resemble moles and are generally black or dark brown.

Latest Research and Reviews

  • Research | | open

    LNK is a tumor suppressor in hematopoietic cancers, but its function in melanoma is unclear. Here, the authors show that the overexpression of LNK in melanomas correlate with hyperactive signaling of the RAS-RAF-MEK pathway and LNK enhances melanoma growth and survival and immune evasion by inhibiting IFN signalling.

    • Ling-Wen Ding
    • , Qiao-Yang Sun
    • , Jarem J. Edwards
    • , Lucia Torres Fernández
    • , Xue-Bin Ran
    • , Si-Qin Zhou
    • , Richard A. Scolyer
    • , James S. Wilmott
    • , John F. Thompson
    • , Ngan Doan
    • , Jonathan W. Said
    • , Nachiyappan Venkatachalam
    • , Jin-Fen Xiao
    • , Xin-Yi Loh
    • , Maren Pein
    • , Liang Xu
    • , David W. Mullins
    • , Henry Yang
    • , De-Chen Lin
    •  & H. Phillip Koeffler
  • Reviews |

    Immune-checkpoint inhibitors (ICIs) have dramatically improved the survival of patients with certain forms of cancer; however, these agents also have adverse effects that are often quite different to those of more traditional cancer therapies. In this Review, the authors describe the epidemiology, treatment and management of the various immune-related adverse events that can occur in patients receiving ICIs.

    • Filipe Martins
    • , Latifyan Sofiya
    • , Gerasimos P. Sykiotis
    • , Faiza Lamine
    • , Michel Maillard
    • , Montserrat Fraga
    • , Keyvan Shabafrouz
    • , Camillo Ribi
    • , Anne Cairoli
    • , Yan Guex-Crosier
    • , Thierry Kuntzer
    • , Olivier Michielin
    • , Solange Peters
    • , Georges Coukos
    • , Francois Spertini
    • , John A. Thompson
    •  & Michel Obeid
  • Research | | open

    The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.

    • Shun Li
    • , Ying Song
    • , Christine Quach
    • , Hongrui Guo
    • , Gyu-Beom Jang
    • , Hadi Maazi
    • , Shihui Zhao
    • , Nathaniel A. Sands
    • , Qingsong Liu
    • , Gino K. In
    • , David Peng
    • , Weiming Yuan
    • , Keigo Machida
    • , Min Yu
    • , Omid Akbari
    • , Ashley Hagiya
    • , Yongfei Yang
    • , Vasu Punj
    • , Liling Tang
    •  & Chengyu Liang

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