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Cancer

Epigenetic control of cancer inflammation

Nature Cell Biology volume 25, pages 1245–1246 (2023)Cite this article

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The interaction of non-immune and immune cells in the tumour microenvironment (TME) determines the quality of the immune attack on nascent tumour cells. A new study in melanoma cells shows that specific histone variants dampen the expression of cytokine genes in cancer-associated fibroblasts, leading to an immunosuppressive TME.

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Fig. 1: MacroH2A histone variants modulate the tumour microenvironment in melanoma.

References

  1. Hanahan, D. Cancer Discov. 12, 31–46 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Atkins, M. B. et al. Clin. Cancer Res. 27, 2678–2697 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Davidson, S. et al. Cell Rep. 31, 107628 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Papaccio, F. et al. Int. J. Mol. Sci. 22, 7255 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Buschbeck, M. & Hake, S. B. Nat. Rev. Mol. Cell Biol. 18, 299–314 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Creppe, C. et al. Mol. Cell Biol. 32, 1442–1452 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hsu, C.-J., Meers, O., Buschbeck, M. & Heidel, F. H. Cancers 13, 3003 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kapoor, A. et al. Nature 468, 1105–1109 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Filipescu, D. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01208-7 (2023).

    Article  PubMed  Google Scholar 

  10. Corujo, D. et al. Cell Rep. 39, 110988 (2022).

    Article  CAS  PubMed  Google Scholar 

  11. Kim, J. et al. Cell Rep. 24, 224–237 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Douet, J. et al. J. Cell Sci. 130, 1570–1582 (2017).

    CAS  PubMed  Google Scholar 

  13. Gamble, M. J., Frizzell, K. M., Yang, C., Krishnakumar, R. & Kraus, W. L. Gene Dev. 24, 21–32 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ismail, W. M. et al. Commun. Biol. 6, 215 (2023).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Cancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus Can Ruti, Badalona, Spain

    David Corujo & Marcus Buschbeck

  2. Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain

    Marcus Buschbeck

Authors
  1. David Corujo
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  2. Marcus Buschbeck
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Correspondence to Marcus Buschbeck.

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Competing interests

M.B. has been receiving support for unrelated research from CellCentric Ltd.

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Corujo, D., Buschbeck, M. Epigenetic control of cancer inflammation. Nat Cell Biol 25, 1245–1246 (2023). https://doi.org/10.1038/s41556-023-01183-z

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