Featured
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Article |
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling
Genome function is influenced by the three-dimensional organization of chromosomes. Kalhor et al. experimentally detect low-frequency intra- and interchromosomal interactions previously obscured by noise and use these data to model the genome architectures of populations of cells.
- Reza Kalhor
- , Harianto Tjong
- & Lin Chen
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Primer |
How to apply de Bruijn graphs to genome assembly
A mathematical concept known as a de Bruijn graph turns the formidable challenge of assembling a contiguous genome from billions of short sequencing reads into a tractable computational problem.
- Phillip E C Compeau
- , Pavel A Pevzner
- & Glenn Tesler
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Commentary |
Biomedical technology and the clinic of the future
Technology pioneers trade views with a clinician and an entrepreneur on the likely impact of large-scale systems technology in healthcare.
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News Feature |
Up in a cloud?
Cloud computing offers solutions for companies wrestling with large-scale data sets, but security issues will likely continue to restrict its use to precompetitive or nonconfidential data. Clare Sansom reports.
- Clare Sansom
Detecting and annotating genetic variations using the HugeSeq pipeline
CompBio 2.0