Lymphoma articles within Nature Communications

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  • Article
    | Open Access

    Enteropathy associated T-cell lymphoma -EATL- affects the intestine and there are two different subtypes. In this study, the authors carry out exome sequencing of the type II variant and find that it is characterized by recurrent mutations in the histone methyltransferase SETD2 that are accompanied by altered H3K6 methylation.

    • Annalisa Roberti
    • , Maria Pamela Dobay
    •  & Laurence de Leval

  • Article
    | Open Access

    The synergism between c-MYC and miR-17-19b plays an important role in lymphoma initiation. In this study, the authors identify a panel of targets co-regulated by miR-17-19b and in MYC-driven lymphoma and unravel the molecular mechanism through which miR-17-19b inhibits MYCtranslation.

    • Marija Mihailovich
    • , Michael Bremang
    •  & Tiziana Bonaldi

  • Article
    | Open Access

    p53 can be activated by oncogenic stress to suppress tumourigenesis, but its role in radiation carcinogenesis has not been studied in p53 wild-type mice. Here, Lee et al. show that knocking down p53 during total-body irradiation not only reduces acute toxicity, but prevents the formation of radiation-induced lymphoma.

    • Chang-Lung Lee
    • , Katherine D. Castle
    •  & David G. Kirsch

  • Article
    | Open Access

    Immune system diversity is generated by V(D)J recombination, leading to clonal T-cell lineages. Here the authors investigate the events leading to T-cell diversity through the use of a modified PCR technique combined with deep sequencing.

    • Eliana Ruggiero
    • , Jan P. Nicolay
    •  & Christof von Kalle

  • Article
    | Open Access

    IDH1- and IDH2-mutant cancer cells aberrantly accumulate D2-hydroxyglutarate (D2-HG). Here, Lin et al. find loss-of-function mutations in D2-hydroxyglutarate dehydrogenase (D2HGDH), which converts D2-HG to alpha-ketoglutarate (α-KG), in diffuse large B-cell lymphomas and show that D2HGDH via α-KG regulates the expression and activity of IDH2.

    • An-Ping Lin
    • , Saman Abbas
    •  & Ricardo C. T. Aguiar

  • Article |

    Telodendrimers are versatile and robust nanoparticle-based drug carriers. From a screen of potential small-molecule building blocks, Shi et al.identify rhein-containing telodendrimers as stable and effective nanocarriers of doxorubicin for treating a xenograft Raji lymphoma model.

    • Changying Shi
    • , Dandan Guo
    •  & Juntao Luo

  • Article
    | Open Access

    The contribution of epigenomic alterations to tumour progression and relapse is not well characterized. Here the authors characterize epigenetic evolution in aggressive B-cell lymphoma and find that epigenomic heterogeneity may not only support and drive the relapse phenotype but also be used to predict lymphoma relapse.

    • Heng Pan
    • , Yanwen Jiang
    •  & Olivier Elemento

  • Article
    | Open Access

    TAL1 is frequently deregulated in T-cell acute lymphoblastic leukaemias, but the mechanism remains largely unclear. Here the authors show that microinsertions upstream of TAL1 cause its epigenetic reactivation, and that the mode of TAL1activation correlates with prognosis.

    • Jean-Marc Navarro
    • , Aurore Touzart
    •  & Bertrand Nadel

  • Article |

    NK-cell and γδ-T cell lymphoma share clinic-pathological features; however the driving mutations are largely unknown. Here the authors, using a combination of RNA-Seq analysis, targeted re-sequencing and functional analysis, identify frequent activating mutations in STAT3 and STAT5Bthat may be driver mutations in these diseases.

    • Can Küçük
    • , Bei Jiang
    •  & Wing C. Chan

  • Article |

    Protein fusions between the paracaspase MALT1 and API2 (inhibitor of apoptosis 2) are found in B-cell lymphoma. Here the authors identify the tumour suppressor LIMA1 as a new target of API2–MALT1 chimeric protein and show that API2–MALT1-mediated proteolysis generates a LIM domain-only (LMO)-containing fragment with oncogenic properties in vitro and in vivo.

    • Zilin Nie
    • , Ming-Qing Du
    •  & Kojo S. J. Elenitoba-Johnson

  • Article
    | Open Access

    Marginal zone lymphoma (MZL) is a common subtype of B-cell non-Hodgkin lymphoma. Here the authors carry out a two-stage genome-wide association study in over 8,000 Europeans and identify two new MZL risk loci at chromosome 6p, implicating the major histocompatibility complex in the disease for the first time.

    • Joseph Vijai
    • , Zhaoming Wang
    •  & Alexandra Nieters

  • Article
    | Open Access

    Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive and heterogeneous type of non-Hodgkin’s lymphoma. Here the authors demonstrate that the differential regulation of eIF4E1 and eIF4E3 by the MAPK-interacting kinases is involved in DLBCL aetiology through modification of the cellular translatome.

    • Ari L. Landon
    • , Parameswary A. Muniandy
    •  & Ronald B. Gartenhaus

  • Article |

    While Hodgkin lymphoma (HL) is a common cancer affecting young adults in Western countries, its genetic basis is poorly understood. Here, the authors carry out a genome-wide association analysis in HL patients and healthy controls; identifying a new HL risk locus and implicating TCF3in the disease aetiology.

    • W. Cozen
    • , M. N. Timofeeva
    •  & J. D. McKay

  • Article |

    Hodgkin’s lymphoma has a genetic component that is poorly understood. In this study, Frampton et al. perform a genome-wide association study in German patients and combine the results with a previously published UK genome-wide association study to identify susceptibility loci at 3p24.1 and 6q23.3.

    • Matthew Frampton
    • , Miguel Inacio da Silva Filho
    •  & Richard S. Houlston

  • Article |

    The human germinal centre-associated lymphoma gene is expressed in germinal centre B-lymphocytes; however, its function is unknown. Here the authors show that human germinal centre-associated lymphoma activates Syk kinase, leading to lymphoid hyperplasia and systemic reactive amyloid A amyloidosis in transgenic mice.

    • Isabel Romero-Camarero
    • , Xiaoyu Jiang
    •  & Izidore S Lossos

  • Article
    | Open Access

    Chk2 is a kinase that is a potential chemotherapeutic target. Here, Chk2 and the kinase ERK are shown to functionally interact, and are elevated in expression in human diffuse B-cell lymphomas. Combinatorial inhibition of the kinases was also shown to block tumour growth in anin vivomouse model.

    • Bojie Dai
    • , X. Frank Zhao
    •  & Ronald B. Gartenhaus

  • Article
    | Open Access

    Inflammation can result in the formation of tumours, but the immune system is also involved in the elimination of cancer cells. Here, the authors show that inflammation driven by tumour-specific CD4+T cells results in tumour regression and identify a list of cytokines associated with cancer prevention.

    • Ole Audun Werner Haabeth
    • , Kristina Berg Lorvik
    •  & Alexandre Corthay

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