Lymphoid tissues articles within Nature Communications

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• Article
  04 December 2017 | Open Access

  Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus

  Mouse γδ T cells have diverse functional subsets, but how these subsets are programmed during their development is still unclear. Here the authors show that three surface markers, CD117, CD200 and CD371, refine the development of γδ T cells in the thymus into three pathways programming distinct γδ T cell subsets.

  • Terkild Brink Buus
  • , Niels Ødum
  •  & Jens Peter Holst Lauritsen

• Article
  26 September 2017 | Open Access

  Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes

  CD4 and CD8 T cells develop in the thymus with their transcription programs controlled by ThPOK and Runx3, respectively. Here the authors show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.

  • Satoshi Kojo
  • , Hirokazu Tanaka
  •  & Ichiro Taniuchi

• Article
  28 August 2017 | Open Access

  Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

  The growth of lymph nodes in response to infection requires lymphangiogenesis. Dubey et al. show that the mesenteric lymph node lymphangiogenesis upon helminth infection depends on the signaling loop between the B and fibroblastic reticular cells (FRCs), whereby the FRCs respond to lymphotoxin secreted by B cells by releasing B cell activating factor.

  • Lalit Kumar Dubey
  • , Praneeth Karempudi
  •  & Nicola L. Harris

• Article
  08 February 2017 | Open Access

  Foxn1-β5t transcriptional axis controls CD8⁺ T-cell production in the thymus

  Foxn1 is involved in thymic epithelial cell (TEC) and CD8⁺T cell development. Here the authors show this development requires Foxn1 binding proximal to, and inducing transcription of, the gene encoding β5t in cortical TECs.

  • Muhammad Myn Uddin
  • , Izumi Ohigashi
  •  & Yousuke Takahama

• Article
  10 October 2016 | Open Access

  Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets

  A recent advance in invariant natural killer T cell (iNKT) cell biology is their classification into iNKT1, iNKT2 and iNKT17 subsets. Here the authors provide a transcriptomic analysis of these thymic subsets from Balb/c and C57Bl/6 mice that supports and extends the categorization.

  • Hristo Georgiev
  • , Inga Ravens
  •  & Günter Bernhardt

• Article
  01 September 2016 | Open Access

  Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation

  Fat-associated lymphoid clusters (FALC) in the serous cavities house rapid IgM-producing B1 cells, but how the clusters are activated to respond to infection is unclear. Here the authors show that in response to lung inflammation or pleural nematode infection adipose stromal cell-derived IL-33 activates ILC2s to produce IL-5, thus driving the B1 response in the FALCs.

  • Lucy H. Jackson-Jones
  • , Sheelagh M. Duncan
  •  & Cécile Bénézech

• Article
  23 May 2016 | Open Access

  CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

  T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.

  • Wenqiang Cao
  • , Jing Guo
  •  & Lie Wang

• Article
  29 February 2016 | Open Access

  Increased generation of Foxp3⁺ regulatory T cells by manipulating antigen presentation in the thymus

  The degree of Treg self-antigen reactivity varies across experimental systems. Here the authors develop a new model of skin autoimmunity and show that the size of tissue-specific Treg pool in the thymus depends on AIRE, the availability of the tissue antigen, and its presentation by dendritic cells.

  • Jiqiang Lin
  • , Lu Yang
  •  & Juan J. Lafaille

• Article | 27 November 2015

  Infection-induced type I interferons activate CD11b on B-1 cells for subsequent lymph node accumulation

  Tissue-resident B-1 cells express CD11b, unlike their lymphoid organ-residing counterparts. Here the authors show that influenza-induced type I interferons activate CD11b on B-1 cells, facilitating entry to mediastinal lymph nodes, where they provide the first line of antibody-mediated host defense.

  • Elizabeth E. Waffarn
  • , Christine J. Hastey
  •  & Nicole Baumgarth

• Article
  04 November 2015 | Open Access

  Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

  Jmjd6 is a dioxygenase that catalyses lysyl hydroxylation of splicing regulatory proteins. Here the authors show that Jmjd6 directs splicing of a central tolerance regulator Aire in medullary thymic epithelial cells, and that Jmjd6 deficiency leads to loss of Aire and multi-organ autoimmunity in mice.

  • Toyoshi Yanagihara
  • , Fumiyuki Sanematsu
  •  & Fukui Yoshinori

• Article
  05 October 2015 | Open Access

  ‘Emergency exit’ of bone-marrow-resident CD34⁺DNAM-1^brightCXCR4⁺-committed lymphoid precursors during chronic infection and inflammation

  Lymphocytes are on high demand during chronic infections. Here, the authors show that human lymphoid precursors, normally found in the bone marrow, circulate in the blood of chronic inflammation patients and give rise to natural killer cells and other lymphocytes.

  • Federica Bozzano
  • , Francesco Marras
  •  & Andrea De Maria

• Article
  23 June 2015 | Open Access

  Thymoproteasomes produce unique peptide motifs for positive selection of CD8⁺ T cells

  Proteasomes digest intracellular proteins into peptides that are then presented to lymphocytes as antigens. Here the authors show that a thymic epithelium-specific proteasome subunit cuts model proteins in a pattern favouring their weak binding to T cell receptor, and thus T cell positive selection.

  • Katsuhiro Sasaki
  • , Kensuke Takada
  •  & Shigeo Murata

• Article
  14 May 2015 | Open Access

  Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

  Both sterile and microbial injuries lead to rapid neutrophil recruitment to the site of inflammation. Here the authors show that only neutrophils responding to microbial ligands leave inflamed skin and migrate to draining lymph nodes where they stimulate lymphocyte proliferation.

  • Henry R. Hampton
  • , Jacqueline Bailey
  •  & Tatyana Chtanova

• Article | 20 January 2015

  Vaginal type-II mucosa is an inductive site for primary CD8⁺ T-cell mucosal immunity

  Priming of naïve T cells is thought to occur in tissue-draining lymph nodes. Here Wang et al. show that vaginal mucosa, despite lacking structured lymphoid organs, can support priming of naïve CD8 T-cell responses and activation of memory CD8 T cells.

  • Yichuan Wang
  • , Yongjun Sui
  •  & Jay A. Berzofsky

• Article
  09 January 2015 | Open Access

  CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes

  Innate lymphoid cells have an important role in mucosal immunity and present peptide:MHCII to CD4 T cells. Here the authors show that innate lymphoid cell subsets migrate from the gut mucosa to the draining lymph nodes via different mechanisms, where they form distinct microenvironments.

  • Emma C. Mackley
  • , Stephanie Houston
  •  & David R. Withers

• Article
  30 June 2014 | Open Access

  Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool

  SHP-1 signalling is required for the normal development of B lymphocytes but its role in the terminal differentiation of these cells has not been fully established. Here, the authors show that SHP-1 ablation impairs the establishment of long-lived bone marrow-resident plasma cells due to aberrant integrin activation.

  • Yan-Feng Li
  • , Shengli Xu
  •  & Kong-Peng Lam

• Article | 17 December 2013

  Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T-cell development

  Cervical thymi are secondary sites of T-cell development in mice. Here, the authors investigate previously unknown origin of cervical thymi and show that they develop as a by-product of the normal separation of thymic and parathyroid tissue.

  • Jie Li
  • , Zhijie Liu
  •  & Nancy R. Manley

• Article | 28 November 2013

  Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade

  Thymic stromal lymphopoietin is an important initiator of Th2 responses, but, to date, little is known about how it drives the immune cascade in the tissue microenvironment in vivo. Here, the authors show that skin thymic stromal lymphopoietin orchestrate interactions between immune cells, leading to Th2 priming.

  • Juan Manuel Leyva-Castillo
  • , Pierre Hener
  •  & Mei Li

• Article | 27 November 2013

  Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output

  Thymic epithelial cells provide the microenvironment required for the expansion of T cells in the thymus, but their exact function is not well understood. Here, the authors report that thymic epithelial cells are the source of matricellular protein CYR61, which is involved in thymic function and T cell development.

  • Yalin Emre
  • , Magali Irla
  •  & Beat A. Imhof

• Article
  19 June 2013 | Open Access

  Exploring the MHC-peptide matrix of central tolerance in the human thymus

  T cells learn to tolerate self-antigens in the thymus, where self-peptides are presented by thymic antigen-presenting cells. Here, the authors present an ex vivomass spectrometric analysis of the self-peptide repertoire associated with MHC I and II in human thymic tissue.

  • Eleni Adamopoulou
  • , Stefan Tenzer
  •  & Christina Stoeckle

• Article | 03 April 2013

  Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

  Klf5 is a transcription factor that regulates self-renewal of pluripotent stem cells. Here the authors test the function of Klf5 in somatic stem cells, and discover that it controls stem cell homing and adhesion by regulating endocytosis of beta integrins.

  • E. Taniguchi Ishikawa
  • , K. H. Chang
  •  & J. A. Cancelas

• Article | 02 October 2012

  Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

  Autoreactive T cells are eliminated as they encounter self-antigens during transit through the thymus. Uedaet al. reveal that mice lacking the Hippo homologue Mst1 develop autoimmunity as a result of impaired integrin-dependent T cell migration through this negatively selective niche.

  • Yoshihiro Ueda
  • , Koko Katagiri
  •  & Tatsuo Kinashi