Spleen articles within Nature Communications

Featured

• Article
  17 June 2023 | Open Access

  Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4⁺ T cell fate

  It is debated how follicular helper T (Tfh) cells versus central memory CD4⁺ T cells arise from similar precursors, and little is known about the regulation of germinal-centre (GC)-Tfh cell differentiation. Here, authors establish markers in the early precursor stage that distinguish between the GC-Tfh and memory T cell fates and identify an important mechanism that regulates the competitive fitness of the GC-Tfh cells.

  • Fangming Zhu
  • , Ryan J. McMonigle
  •  & Hui Hu

• Article
  15 April 2019 | Open Access

  Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp

  The white pulp of spleen is an important immune structure dynamically modulated during development and immune responses. Here the authors define, using multi-color lineage tracing and single-cell transcriptome analysis, the subset distribution and differentiation trajectory of fibroblastic reticular cells to serve structural insights for splenic white pulps.

  • Hung-Wei Cheng
  • , Lucas Onder
  •  & Burkhard Ludewig