Lymphocyte differentiation

Lymphocyte differentiation is a process in which activated B cells or T cells become specialized immune cells. For example, B cells can give rise to antibody-producing cells and T cells can differentiate into cytotoxic T cells. Lymphocytes can also differentiate into memory cells that provide immunological memory to infections.

Latest Research and Reviews

  • Research | | open

    Both thymic epithelial cells and dendritic cells present self antigens in the thymus to mediate thymic selection and T cell tolerance. Here the authors quantify, using two-photon live imaging of mouse thymic slices, the relative contribution of these two cell types, as well as the effects of antigen cross-presentation by dendritic cells, during tolerance induction.

    • J. N. Lancaster
    • , H. M. Thyagarajan
    • , J. Srinivasan
    • , Y. Li
    • , Z. Hu
    •  & L. I. R. Ehrlich
  • Research | | open

    • Xiangyu Chen
    • , Guoshuai Cao
    • , Jialin Wu
    • , Xinxin Wang
    • , Zhiwei Pan
    • , Jianbao Gao
    • , Qin Tian
    • , Lifan Xu
    • , Zhirong Li
    • , Yaxing Hao
    • , Qizhao Huang
    • , Pengcheng Wang
    • , Minglu Xiao
    • , Luoyingzi Xie
    • , Shupei Tang
    • , Zhenyu Liu
    • , Li Hu
    • , Jianfang Tang
    • , Ran He
    • , Li Wang
    • , Xinyuan Zhou
    • , Yuzhang Wu
    • , Mengjie Chen
    • , Beicheng Sun
    • , Bo Zhu
    • , Jun Huang
    •  & Lilin Ye
  • Research |

    Stemness is crucial for the maintenance of long-term T cell memory. Gattinoni and colleagues demonstrate that the transcription factor c-Myb is essential for the establishment of a stemness program in the CD8+ T cell memory compartment.

    • Sanjivan Gautam
    • , Jessica Fioravanti
    • , Wei Zhu
    • , John B. Le Gall
    • , Philip Brohawn
    • , Neal E. Lacey
    • , Jinhui Hu
    • , James D. Hocker
    • , Nga Voong Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Devikala Gurusamy
    • , Zhiya Yu
    • , Avinash Bhandoola
    • , Hai-Hui Xue
    • , Rahul Roychoudhuri
    • , Brandon W. Higgs
    • , Nicholas P. Restifo
    • , Timothy P. Bender
    • , Yun Ji
    •  & Luca Gattinoni
    Nature Immunology 20, 337-349
  • Research |

    An intricately linked homeostasis exists between the gut microbiome and host immune system. Scheffold and colleagues show that intestinal Treg cells upregulate the transcription factor c-Maf in response to specific signals from the gut microenvironment to establish host–microbiota homeostasis.

    • Christian Neumann
    • , Jonas Blume
    • , Urmi Roy
    • , Peggy P. Teh
    • , Ajithkumar Vasanthakumar
    • , Alexander Beller
    • , Yang Liao
    • , Frederik Heinrich
    • , Teresita L. Arenzana
    • , Jason A. Hackney
    • , Celine Eidenschenk
    • , Eric J. C. Gálvez
    • , Christina Stehle
    • , Gitta A. Heinz
    • , Patrick Maschmeyer
    • , Tom Sidwell
    • , Yifang Hu
    • , Derk Amsen
    • , Chiara Romagnani
    • , Hyun-Dong Chang
    • , Andrey Kruglov
    • , Mir-Farzin Mashreghi
    • , Wei Shi
    • , Till Strowig
    • , Sascha Rutz
    • , Axel Kallies
    •  & Alexander Scheffold
    Nature Immunology 20, 471-481

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