Long-term potentiation articles within Nature

Featured

  • Article
    | Open Access

    Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

    • Jonathan E. Tullis
    • , Matthew E. Larsen
    •  & K. Ulrich Bayer

  • Article |

    Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.

    • Tristan Geiller
    • , Sadra Sadeh
    •  & Attila Losonczy

  • Letter |

    Live fluorescent imaging of murine hippocampal slices shows that NMDAR-dependent glutamate signalling leads to postsynaptic BDNF release, with associated signalling of its receptor, TrkB, on the same dendritic spine, suggesting autocrine BDNF signalling.

    • Stephen C. Harward
    • , Nathan G. Hedrick
    •  & James O. McNamara

  • Article |

    A new light-activated probe that targets recently active neuronal spines for manipulation induces shrinkage of recently potentiated spines following a motor learning task; spine shrinkage disrupted learning, suggesting a causal relationship between the specific subset of targeted spines and the learned behaviour.

    • Akiko Hayashi-Takagi
    • , Sho Yagishita
    •  & Haruo Kasai

  • Letter |

    Neurons in the basolateral amygdala projecting to canonical fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning, and selectively activating these projection-target-defined neural populations causes either negative or positive reinforcement, respectively.

    • Praneeth Namburi
    • , Anna Beyeler
    •  & Kay M. Tye

  • Article |

    A study of pup retrieval behaviour in mice shows that oxytocin modulates cortical responses to pup calls specifically in the left auditory cortex; in virgin females, call-evoked responses were enhanced, thus increasing their salience, by pairing oxytocin delivery in the left auditory cortex with the calls, suggesting enhancement was a result of balancing the magnitude and timing of inhibition with excitation.

    • Bianca J. Marlin
    • , Mariela Mitre
    •  & Robert C. Froemke

  • Article |

    Ca2+ spikes are generated on different dendritic branches in the primary motor cortex of mice performing different motor learning tasks, causing long-lasting potentiation of postsynaptic dendritic spines; inactivation of a population of interneurons disrupts the spatial separation of Ca2+ spikes and persistent dendritic spine potentiation, suggesting that the generation of Ca2+ spikes on different dendritic branches is crucial for storing information in individual neurons.

    • Joseph Cichon
    •  & Wen-Biao Gan

  • Letter |

    Whole-cell recordings in mouse somatosensory cortex in vivo show that rhythmic sensory-whisker stimulation induces long-term synaptic potentiation (LTP) in layer 2/3 (L2/3) pyramidal cells, in the absence of somatic spikes, through long-lasting NMDAR-mediated depolarizations that are generated by synaptic networks originating from the posteromedial complex of the thalamus.

    • Frédéric Gambino
    • , Stéphane Pagès
    •  & Anthony Holtmaat

  • Letter |

    A rodent study using optogenetics to induce long-term potentiation and long-term depression provides a causal link between synaptic plasticity and memory.

    • Sadegh Nabavi
    • , Rocky Fox
    •  & Roberto Malinow

  • Article |

    The minimal possible requirement for AMPA receptor trafficking during long-term potentiation is explored, revealing that no region of the receptor subunit is necessary, in contrast with previous work; the only requirement for LTP seems to be a large reserve of glutamate receptors.

    • Adam J. Granger
    • , Yun Shi
    •  & Roger A. Nicoll

Browse broader subjects

Browse Long-term potentiation across other nature.com journals