Featured
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News & Views |
Pinprick diagnostics
Rare tumour cells with mutations that confer drug resistance can go undetected by standard testing procedures, according to two studies, which show that such mutations can be detected in patients' blood. See Letters p.532 and p.537
- Eduardo Vilar
- & Josep Tabernero
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Letter |
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice
Consumption of a diet high in milk-derived fat is shown to increase the abundance of sulphite-reducing bacteria by altering bile composition, leading to inflammation and colitis in genetically susceptible mice.
- Suzanne Devkota
- , Yunwei Wang
- & Eugene B. Chang
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Research Highlights |
Cell transplants repair colon
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Letter |
Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
Goblet cells in the small intestine act as passages delivering small antigens to tolerance-inducing dendritic cells in the lamina propria.
- Jeremiah R. McDole
- , Leroy W. Wheeler
- & Mark J. Miller
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Letter |
Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis
- Claudia Günther
- , Eva Martini
- & Christoph Becker
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Review Article |
Genetics and pathogenesis of inflammatory bowel disease
- Bernard Khor
- , Agnès Gardet
- & Ramnik J. Xavier
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Review Article |
Intestinal homeostasis and its breakdown in inflammatory bowel disease
- Kevin J. Maloy
- & Fiona Powrie
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News & Views |
Context is key in the gut
The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220
- Craig L. Maynard
- & Casey T. Weaver
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News & Views |
Genes, viruses and microbes
Variations in several genes can increase an individual's susceptibility to complex disorders. But what tips the balance to cause the full-blown disease? For Crohn's disease, viruses could provide part of the answer.
- Alison Simmons
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites