Featured
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Article |
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Inhibition of the tricarboxylic acid cycle enzyme fumarate hydratase leads to deregulation of cytokine production in macrophages, which has implications in human diseases such as systemic lupus erythematosus.
- Alexander Hooftman
- , Christian G. Peace
- & Luke A. J. O’Neill
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Article |
Structure of the IFNγ receptor complex guides design of biased agonists
The X-ray structure of the hexameric complex of interferon-γ bound to its receptors is solved at 3.25 Å resolution, providing a basis for engineering variants of interferon-γ that enable decoupling of its immunomodulatory functions.
- Juan L. Mendoza
- , Nichole K. Escalante
- & K. Christopher Garcia
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Letter |
A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses
FOXO3 is a negative regulator of IRF7, a master regulator of the antiviral response.
- Vladimir Litvak
- , Alexander V. Ratushny
- & Alan Aderem
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Letter |
A diverse range of gene products are effectors of the type I interferon antiviral response
- John W. Schoggins
- , Sam J. Wilson
- & Charles M. Rice
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Letter |
Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
Using a mouse model of Mycobacterium avium infection, it is shown here that interferon-γ regulates the proliferation of primitive haematopoietic cells during chronic infection.
- Megan T. Baldridge
- , Katherine Y. King
- & Margaret A. Goodell
Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity