Inflammatory bowel disease

Inflammatory bowel disease is a chronic condition of unknown origin characterized by severe inflammation and mucosal destruction in the intestine. There are two main forms: Crohn’s disease, which can affect the entire gastrointestinal tract, but is most common in the colon and terminal ileum; and ulcerative colitis, which is a mucosal inflammation involving the rectum and colon.

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Latest Research and Reviews

  • Research | | open

    Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.

    • Samuel J. S. Rubin
    • , Lawrence Bai
    • , Yeneneh Haileselassie
    • , Gotzone Garay
    • , Chohee Yun
    • , Laren Becker
    • , Sarah E. Streett
    • , Sidhartha R. Sinha
    •  & Aida Habtezion
  • Research |

    Here, the authors apply quantitative microbiome profiling to a metagenomics data set comprising patients with primary sclerosing cholangitis and/or inflammatory bowel disease and identify microbial taxa associated with inflammation or specific disease indicators, which were validated in an independent inflammatory bowel disease cohort.

    • Sara Vieira-Silva
    • , João Sabino
    • , Mireia Valles-Colomer
    • , Gwen Falony
    • , Gunter Kathagen
    • , Clara Caenepeel
    • , Isabelle Cleynen
    • , Schalk van der Merwe
    • , Séverine Vermeire
    •  & Jeroen Raes
  • Reviews | | open

    Over ten years, the Human Microbiome Project has provided resources for studying the microbiome and its relationship to disease; this Perspective summarizes the key achievements and findings of the project and its relationship to the broader field.

    • Lita M. Proctor
    • , Heather H. Creasy
    • , Jennifer M. Fettweis
    • , Jason Lloyd-Price
    • , Anup Mahurkar
    • , Wenyu Zhou
    • , Gregory A. Buck
    • , Michael P. Snyder
    • , Jerome F. Strauss III
    • , George M. Weinstock
    • , Owen White
    •  & Curtis Huttenhower
    Nature 569, 641-648
  • Research | | open

    The Inflammatory Bowel Disease Multi’omics Database includes longitudinal data encompassing a multitude of analyses of stool, blood and biopsies of more than 100 individuals, and provides a comprehensive description of host and microbial activities in inflammatory bowel diseases.

    • Jason Lloyd-Price
    • , Cesar Arze
    • , Ashwin N. Ananthakrishnan
    • , Melanie Schirmer
    • , Julian Avila-Pacheco
    • , Tiffany W. Poon
    • , Elizabeth Andrews
    • , Nadim J. Ajami
    • , Kevin S. Bonham
    • , Colin J. Brislawn
    • , David Casero
    • , Holly Courtney
    • , Antonio Gonzalez
    • , Thomas G. Graeber
    • , A. Brantley Hall
    • , Kathleen Lake
    • , Carol J. Landers
    • , Himel Mallick
    • , Damian R. Plichta
    • , Mahadev Prasad
    • , Gholamali Rahnavard
    • , Jenny Sauk
    • , Dmitry Shungin
    • , Yoshiki Vázquez-Baeza
    • , Richard A. White III
    • , Jason Bishai
    • , Kevin Bullock
    • , Amy Deik
    • , Courtney Dennis
    • , Jess L. Kaplan
    • , Hamed Khalili
    • , Lauren J. McIver
    • , Christopher J. Moran
    • , Long Nguyen
    • , Kerry A. Pierce
    • , Randall Schwager
    • , Alexandra Sirota-Madi
    • , Betsy W. Stevens
    • , William Tan
    • , Johanna J. ten Hoeve
    • , George Weingart
    • , Robin G. Wilson
    • , Vijay Yajnik
    • , Jonathan Braun
    • , Lee A. Denson
    • , Janet K. Jansson
    • , Rob Knight
    • , Subra Kugathasan
    • , Dermot P. B. McGovern
    • , Joseph F. Petrosino
    • , Thaddeus S. Stappenbeck
    • , Harland S. Winter
    • , Clary B. Clish
    • , Eric A. Franzosa
    • , Hera Vlamakis
    • , Ramnik J. Xavier
    •  & Curtis Huttenhower
    Nature 569, 655-662

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