Epithelial cells, macrophages and T cells are linked in a previously unknown regulatory circuit. Sensing of interferon-γ triggers antigen presentation by colonic epithelial cells, enabling T cells to lower extracellular ATP levels and reduce inflammation.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Malik, X. et al. Nature https://doi.org/10.1038/s41586-023-06721-1 (2023).
Cui, D., Huang, G., Yang, D., Huang, B. & An, B. Clin. Res. Hepatol. Gastroenterol. 37, 507–513 (2013).
Hegazy, A. N. et al. Gastroenterology 153, 1320–1337.e1316 (2017).
Nagashima, K. et al. Nature 621, 162–170 (2023).
Friedman, D. J. et al. Proc. Natl Acad. Sci. USA 106, 16788–16793 (2009).
Huang, B. et al. Cell 179, 1160–1176.e1124 (2019).
Acknowledgements
This work was supported by the German Research Foundation (DFG), project ID 403224013–SFB 1382 (B06) and DFG PA921/8-1.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Pabst, O., Cerovic, V. Interferon-γ sensing by epithelial cells tames gut inflammation. Nat Immunol 25, 9–10 (2024). https://doi.org/10.1038/s41590-023-01705-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01705-9