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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells
NKp46 recognizes externalized calreticulin, which translocates from the ER to the cell membrane during ER stress, indicating a danger-associated molecular pattern that eliminates ER-stressed cells.
- Sumit Sen Santara
- , Dian-Jang Lee
- & Judy Lieberman
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Caspase-7 activates ASM to repair gasdermin and perforin pores
Caspase-7 cleaves and activates acid sphingomyelinase (ASM), which promotes the repair of gasdermin pores and thereby delays pore-driven lysis to allow other processes such as extrusion or apoptosis to occur before cell death.
- Kengo Nozaki
- , Vivien I. Maltez
- & Edward A. Miao
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Article |
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Antibody-mediated SARS-CoV-2 uptake by monocytes and macrophages triggers inflammatory cell death that aborts the production of infectious virus but causes systemic inflammation that contributes to COVID-19 pathogenesis.
- Caroline Junqueira
- , Ângela Crespo
- & Judy Lieberman
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Letter |
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis
Caspase-8 suppresses apoptosis and necroptosis in embryonic mice by cleaving RIPK1.
- Kim Newton
- , Katherine E. Wickliffe
- & Vishva M. Dixit
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Letter |
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.
- Alejandra Mendoza
- , Victoria Fang
- & Susan R. Schwab
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Letter |
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Chemotherapy drugs can cause pyroptotic cell death by activating caspase-3 to cleave gasdermin E, potentially contributing to their toxicity and adverse effects.
- Yupeng Wang
- , Wenqing Gao
- & Feng Shao
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Letter |
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.
- Jonathan J. Kotzin
- , Sean P. Spencer
- & Jorge Henao-Mejia
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Article |
Pore-forming activity and structural autoinhibition of the gasdermin family
The N-terminal domains of gasdermin proteins cause pyroptotic cell death by oligomerizing to form membrane pores.
- Jingjin Ding
- , Kun Wang
- & Feng Shao
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Letter |
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis
Non-alcoholic fatty liver disease (NAFLD) is shown to promote hepatocellular carcinoma through the generation of linoleic acid, disruption of mitochondrial function and selective loss of CD4+ T cells, leading to impaired anti-tumour immunity.
- Chi Ma
- , Aparna H. Kesarwala
- & Tim F. Greten
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Article |
Inflammatory caspases are innate immune receptors for intracellular LPS
Caspase-4 and caspase-11 are shown to be the direct sensors for cytoplasmic lipopolysaccharide in humans and mice, respectively, mediating inflammatory cell death in intracellular bacterial infection.
- Jianjin Shi
- , Yue Zhao
- & Feng Shao
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Letter |
Dampening of death pathways by schnurri-2 is essential for T-cell development
The zinc-finger-containing protein schnurri-2 is shown to regulate positive selection in T-cell development by dampening the mitochondrial death pathway.
- Tracy L. Staton
- , Vanja Lazarevic
- & Laurie H. Glimcher
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury