Homogeneous catalysis

Homogeneous catalysis is a type of catalysis in which the catalyst operates in the same phase as the reactants — usually dissolved in a solvent. Mechanistic studies of homogeneous catalysts are generally easier than those of heterogeneous catalysts, which aids optimization. They can, however, be difficult to separate from the products and thus recycle.

Latest Research and Reviews

  • Research | | open

    Chemo-enzymatic tandem processes allow access to more complex non-racemic products. Here, the authors show that non-ionic surfactants, especially the tailor-made surfactant TPGS-750-M, enhance the activity of alcohol dehydrogenase to afford stereopure products in a 1-pot reaction.

    • Margery Cortes-Clerget
    • , Nnamdi Akporji
    • , Jianguang Zhou
    • , Feng Gao
    • , Pengfei Guo
    • , Michael Parmentier
    • , Fabrice Gallou
    • , Jean-Yves Berthon
    •  & Bruce H. Lipshutz
  • Reviews |

    Water oxidation catalysts are key components in water-splitting devices that synthesize fuels by using energy, including that from sunlight. This Perspective presents historical developments in molecular water oxidation catalysis, emphasizing studies of ruthenium complexes that have taught us how to design optimal catalysts.

    • Roc Matheu
    • , Pablo Garrido-Barros
    • , Marcos Gil-Sepulcre
    • , Mehmed Z. Ertem
    • , Xavier Sala
    • , Carolina Gimbert-Suriñach
    •  & Antoni Llobet
  • Research | | open

    Classical Suzuki-Miyaura couplings require wasteful electrophilic coupling partners and an exogenous base often engaging in side-reactions. Here, the authors report an alternative Suzuki-type synthesis of biaryls, involving the base-free nickel-catalyzed deformylative coupling of aldehydes with organoboron reagents.

    • Lin Guo
    • , Watchara Srimontree
    • , Chen Zhu
    • , Bholanath Maity
    • , Xiangqian Liu
    • , Luigi Cavallo
    •  & Magnus Rueping
  • Research |

    For hydrogen to become a direct, portable fuel source, the difficulties with its storage and subsequent release must be addressed. Here ethylene glycol is shown to act as an efficient, reversible liquid-to-liquid hydrogen carrier—particularly attractive due to its theoretical H2 capacity of 6.5 wt%.

    • You-Quan Zou
    • , Niklas von Wolff
    • , Aviel Anaby
    • , Yinjun Xie
    •  & David Milstein
    Nature Catalysis 2, 415-422
  • Research | | open

    Asymmetric transformations involving abundant chemical feedstocks such as toluene and its derivatives are rather rare. Here, the authors report the radical enantioselective C(sp3) −C(sp3) coupling of activated ketones with toluenes by means of chiral acid catalysis to afford enantioenriched tertiary alcohols.

    • Fuyuan Li
    • , Dong Tian
    • , Yifan Fan
    • , Richmond Lee
    • , Gang Lu
    • , Yanli Yin
    • , Baokun Qiao
    • , Xiaowei Zhao
    • , Ziwei Xiao
    •  & Zhiyong Jiang

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